Modeling serotonin uptake in the lung shows endothelial transporters dominate over cleft permeation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 1, 2013, Pages

  Jardine, Bartholomew ^a   Bassingthwaighte, James B ^a  

^a University of Washington   (United States)

Author keywords

Capillary tissue exchange; Convection diffusion; Endothelium; Hydroxytryptamine receptors; Pulmonary capillary permeability; Serotonin; Transport modeling

Indexed keywords

SEROTONIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; CONTROLLED STUDY; DOG; ENDOTHELIUM CELL; HEMATOCRIT; INTERSTITIAL FLUID; LUNG ENDOTHELIUM; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SEROTONIN UPTAKE;

CAPILLARY-TISSUE EXCHANGE; CONVECTION-DIFFUSION; ENDOTHELIUM; HYDROXYTRYPTAMINE RECEPTORS; PULMONARY CAPILLARY PERMEABILITY; SEROTONIN; TRANSPORT MODELING;

ANIMALS; BIOLOGICAL TRANSPORT; BRANCHIAL REGION; CELL MEMBRANE PERMEABILITY; DOGS; ENDOTHELIUM, VASCULAR; HUMANS; LUNG; MODELS, BIOLOGICAL; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84879567883     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00420.2012     Document Type: Article

References (52)

1. Audi SH, Krenz GS, Linehan JH, Rickaby DA, Dawson CA. Pulmonary capillary transport function from flow-limited indicators. J Appl Physiol 77: 332-351, 1994.
2. Audi SH, Linehan JH, Krenz GS, Dawson CA. Accounting for the heterogeneity of capillary transit times in modeling multiple indicator dilution data. Ann Biomed Eng 26: 914-930, 1998.
3. Bassingthwaighte JB, Chaloupka M. Sensitivity functions in the estimation of parameters of cellular-exchange. Fed Proc 43: 180-184, 1984.
4. Bassingthwaighte JB, Chan ISJ, Wang CY. Computationally efficient algorithms for convection-permeation-diffusion models for blood-tissue exchange. Ann Biomed Eng 20: 687-725, 1992.
5. Bassingthwaighte JB, Wang CY, Chan IS. Blood-tissue exchange via transport and transformation by capillary endothelial cells. Circ Res 65: 997-1020, 1989.
6. Bassingthwaighte JB. A practical extension of hydrodynamic theory of porous transport for hydrophilic solutes. Microcirculation 13: 111-118, 2006.
7. Bassingthwaighte JB, Raymond GR, Ploger JD, Schwartz LM, Bukowski TR. GENTEX, a general multiscale model for in vivo tissue exchanges and intraorgan metabolism. Phil Trans A Math Phys Eng Sci 364: 1423-1442, 2006.
8. Brenner B, Harney JT, Ahmed BA, Jeffus BC, Unal R, Mehta JL, Kilic F. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem 102: 206-215, 2007.
9. Brigham KL, Harris TR, Owen PJ. [14C]urea and [14C]sucrose as permeability indicators in histamine pulmonary-edema. J Appl Physiol 43: 99-101, 1977.
10. Bronikowski TA, Dawson CA, Linehan JH, Rickaby DA. A mathematical model of indicator extraction by the pulmonary endothelium via saturation kinetics. Math Biosci 61: 237-266, 1982.
11. Bundgaard M. The 3-dimensional organization of tight junctions in a capillary endothelium revealed by serial-section electron-microscopy. J Ultrastruct Res 88: 1-17, 1984.
12. Chan IS, Goldstein AA, Bassingthwaighte JB. SENSOP: a derivativefree solver for nonlinear least-squares with sensitivity scaling. Ann Biomed Eng 21: 621-631, 1993.
13. Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DMF, Stevens T. Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase. J Cell Biol 157: 1267-1278, 2002.
14. Cousineau DF, Goresky CA, Rouleau JR, Rose CP. Microsphere and dilution measurements of flow and interstitial space in dog heart. J Appl Physiol 77: 113-120, 1994.
15. Crone C. Permeability of capillaries in various organs as determined by use of indicator diffusion method. Acta Physiol Scand 58: 292-305, 1963.
16. Crone C. Does 'restricted diffusion' occur in muscle capillaries? Proc Soc Exp Biol Med 112: 453-455, 1963.
17. Dash RK, Bassingthwaighte JB. Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion. Ann Biomed Eng 34: 1129-1148, 2006.
18. Dawson CA, Linehan JH, Rickaby DA, Bronikowski TA. Kinetics of serotonin uptake in the intact lung. Ann Biomed Eng 15: 217-227, 1987.
19. Dixon M, Webb EC. Enzymes. London: Longman, 1979, p. 332-336.
20. Effros RM, Praker JC. Pulmonary vascular heterogeneity and the Starling hypothesis. Microvasc Res 78: 71-77, 2009.
21. Flink JR, Pitt BR, Hammond GL, Gillis CN. Selective effect of microembolization on pulmonary removal of biogenic-amines. J Appl Physiol 52: 421-427, 1982.
22. Geng WP, Schwab AJ, Hori T, Goresky CA, Pang KS. Hepatic uptake of bromosulfophthalein-glutathione in perfused Eisai hyperbilirubinemic mutant rat liver: a multiple-indicator dilution study. J Pharmacol Exp Ther 284: 480-492, 1998.
23. Gonzalez F, Bassingthwaighte JB. Heterogeneities in regional volumes of distribution and flows in the rabbit heart. Am J Physiol Heart Circ Physiol 258: H1012-H1024, 1990.
24. Gorman MW, Bassingthwaighte JB, Olsson RA, Sparks HV. Endothelial cell uptake of adenosine in canine skeletal muscle. Am J Physiol Heart Circ Physiol 250: H482-H489, 1986.
25. Hodgson L, Tarbell JM. Solute transport to the endothelial intercellular cleft: The effect of wall shear stress. Ann Biomed Eng 30: 936-945, 2002.
26. Kellen MR, Bassingthwaighte JB. Transient transcapillary exchange of water driven by osmotic forces in the heart. Am J Physiol Heart Circ Physiol 285: H1317-H1331, 2003.
27. King RB, Raymond GM, Bassingthwaighte JB. Modeling blood flow heterogeneity. Ann Biomed Eng 24: 352-372, 1996.
28. Knopp TJ, Bassingthwaighte JB. Effect of flow on transpulmonary circulatory transport functions. J Appl Physiol 27: 36-43, 1969.
29. Kuikka J, Levin M, Bassingthwaighte JB. Multiple tracer dilution estimates of D-and 2-deoxy-D-glucose uptake by the heart. Am J Physiol Heart Circ Physiol 250: H29-H42, 1986.
30. Linehan JH, Audi SH, Dawson CA. The uptake and metabolism of substrates in the lung. In: Whole Organ Approaches to Cellular Mechanism, edited by Bassingthwaighte J, Goresky CA, Linehan JH. New York: Springer-Verlag, p. 427-437, 1998.
31. Malcorps CM, Dawson CA, Linehan JH, Bronikowski TA, Rickaby DA, Herman AG, Will JA. Lung serotonin uptake kinetics from indicator-dilution and constant-infusion methods. J Appl Physiol 57: 720-730, 1984.
32. Marcos E, Adnot S, Pham MH, Nosjean A, Raffestin B, Hamon M, Eddahibi S. Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. Am J Respir Crit Care Med 168: 487-493, 2003.
33. Meyer EC, Ottaviano R. Right lymphatic duct distribution volume in dogs: relationship to pulmonary interstitial volume. Circ Res 35: 197-203, 1974.
34. Moffett TC, Chan IS, Bassingthwaighte JB. Myocardial serotonin exchange: negligible uptake by capillary endothelium. Am J Physiol Heart Circ Physiol 254: H570-H577, 1988.
35. Neufeld GR, Williams JJ, Graves DJ, Soma LR, Marshall BE. Pulmonary capillary-permeability in man and a canine model of chemical pulmonary-edema. Microvasc Res 10: 192-207, 1975.
36. Ochoa CD, Stevens T. Studies on the cell biology of interendothelial cell gaps. Am J Physiol Lung Cell Mol Physiol 302: L275-L286, 2012.
37. Parker JC, Stevens T, Randall J, Weber DS, King JA. Hydraulic conductance of pulmonary microvascular, and macrovascular endothelial cell monolayers. Am J Physiol Lung Cell Mol Physiol 291: L30-L37, 2006.
38. Parker JC. Hydraulic conductance of lung endothelial phenotypes and Starling safety factors against edema. Am J Physiol Lung Cell Mol Physiol 292: L378-L380, 2007.
39. Peeters FAM, Bronikowski TA, Dawson CA, Linehan JH, Bult H, Herman AG. Kinetics of serotonin uptake in isolated rabbit lungs. J Appl Physiol 66: 2328-2337, 1989.
40. Poulain CA, Finlayson BA, Bassingthwaighte JB. Efficient numerical methods for nonlinear-facilitated transport and exchange in a blood-tissue exchange unit. Ann Biomed Eng 25: 547-564, 1997.
41. Rickaby DA, Linehan JH, Bronikowski TA, Dawson CA. Kinetics of serotonin uptake in the dog lung. J Appl Physiol 51: 405-414, 1981.
42. Rickaby DA, Dawson CA, Linehan JH. Influence of blood and plasmaflow rate on kinetics of serotonin uptake by lungs. J Appl Physiol 53: 677-684, 1982.
43. Rickaby DA, Dawson CA, Linehan JH. Influence of embolism and imipramine on kinetics of serotonin uptake by dog lung. J Appl Physiol 56: 1170-1177, 1984.
44. Royston BD, Webster NR, Nunn JF. Time course of changes in lung permeability and edema in the rat exposed to 100-percent oxygen. J Appl Physiol 69: 1532-1537, 1990.
45. Schwartz LM, Bukowski TR, Revkin JH, Bassingthwaighte JB. Cardiac endothelial transport and metabolism of adenosine and inosine. Am J Physiol Heart Circ Physiol 277: H1241-H1251, 1999.
46. Selinger SL, Bland RD, Demling RH, Staub NC. Distribution volumes of [131I]albumin, [14C]sucrose, and 36Cl in sheep lung. J Appl Physiol 39: 773-779, 1975.
47. Sur C, Betz H, Schloss P. Distinct effects of imipramine on 5-hydroxytryptamine uptake mediated by the recombinant rat serotonin transporter SERT1. J Neurochem 70: 2545-2553, 1998.
48. Talvenheimo J, Fishkes H, Nelson PJ, Rudnick G. The serotonin transporter imipramine receptor: different sodium requirements for imipramine binding and serotonin translocation. J Biol Chem 258: 6115-6119, 1983.
49. Tancredi R, Caldini P, Shanoff M, Permutt S, Zierler K. The pulmonary microcirculation evaluated by tracer dilution techniques. In: Cardiovascular Nuclear Medicine, edited by Strauss HW, Pitt B, James AE. St. Louis, MO: Mosby, 1974, chapt. 17, p. 255-260.
50. Tancredi RG, Yipintsoi T. Interrelationships of flow, intravascular pressure, and tissue perfusion in the measurement of capillary permeability to sodium in isolated dog lung lobes. Circ Res 46: 669-680, 1980.
51. Watts SW. 5-HT in systemic hypertension: foe, friend or fantasy? Clin Sci 108: 399-412, 2005.
52. Yipintsoi T. Single-passage extraction and permeability estimation of sodium in normal dog lungs. Circ Res 39: 523-531, 1976.