Macroporous three-dimensional PDMS scaffolds for Extrahepatic Islet Transplantation

Cell Transplantation

Volumn 22, Issue 7, 2013, Pages 1123-1125

  Pedraza, Eileen ^a,b   Brady, Ann Christina ^a,c   Fraker, Christopher A ^a,b   Molano, R Damaris ^a   Sukert, Steven ^a   Berman, Dora M ^a,c   Kenyon, Norma S ^a,b,c   Pileggi, Antonello ^a,b,c   Ricordi, Camillo ^a,b,c   Stabler, Cherie L ^a,b,c  

^a UNIVERSITY OF MIAMI   (United States)

^b University of Miami College of Engineering   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Extrahepatic sites; Human islets; Islet transplantation; Nonhuman primate islets; Omentum; Poly(dimethylsiloxane) (PDMS); Rat islets; Scaffold

Indexed keywords

DIMETICONE; FIBRIN; INSULIN; MOLECULAR SCAFFOLD; OXYGEN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; IN VITRO STUDY; INSULIN RELEASE; MALE; NONHUMAN; OXYGEN TENSION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT;

ADULT; ANIMALS; CELL SURVIVAL; CHILD, PRESCHOOL; DIMETHYLPOLYSILOXANES; FEMALE; HUMANS; HYDROGELS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MIDDLE AGED; OMENTUM; POROSITY; PRIMATES; RATS; RATS, INBRED LEW; STRESS, MECHANICAL; YOUNG ADULT;

PRIMATES; RATTUS; RODENTIA;

EID: 84879562092     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X657440     Document Type: Article

References (76)

1. Abdi, R.; Fiorina, P.; Adra, C. N.; Atkinson, M.; Sayegh, M. H. I. Immunomodulation by mesenchymal stem cells. Diabetes 57(7):1759-1767; 2008.
2. al-Abdullah, I. H.; Anil Kumar, M. S.; Kelly-Sullivan, D.; Abouna, G. M. Site for unpurified islet transplantation is an important parameter for determination of the outcome of graft survival and function. Cell Transplant 4(3):297-305; 1995.
3. Ao, Z.; Matayoshi, K.; Lakey, J. R.; Rajotte, R. V.; Warnock, G. L. Survival and function of purified islets in the omental pouch site of outbred dogs. Transplantation 56(3):524-529; 1993.
4. Aucoin, L.; Griffith, C. M.; Pleizier, G.; Deslandes, Y.; Sheardown, H. Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations. J. Biomater Sci. Polym. Ed. 13(4):447-462; 2002.
5. Aung, T.; Inoue, K.; Kogire, M.; Doi, R.; Kaji, H.; Tun, T.; Hayashi, H.; Echigo, Y.; Wada, M.; Imamura, M. Comparison of various gels for immobilization of islets in bioartificial pancreas using a mesh-reinforced polyvinyl alcohol hydrogel tube. Transplant Proc. 27(1):619-621; 1995.
6. Bennet, W.; Groth, C. G.; Larsson, R.; Nilsson, B.; Korsgren, O. Isolated human islets trigger an instant blood mediated inflammatory reaction: Implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes. Upsala Journal of Medical Sciences 105(2):125-133; 2000.
7. Berman, D. M.; O'Neil, J. J.; Coffey, L. C.; Chaffanjon, P. C.; Kenyon, N. M.; Ruiz, P., Jr.; Pileggi, A.; Ricordi, C.; Kenyon, N. S. Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am. J. Transplant 9(1):91-104; 2009.
8. Kleiner, G.; Kenyon, N. M.; Cabrera, O.; Karl, J. A.; Wiseman, R. W.; O'Connor, D. H.; Bartholomew, A. M. Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates. Diabetes 59(10):2558-2568; 2010.
9. Bernik, D. L. Silicon based materials for drug delivery devices and implants. Recent Pat. Nanotechnol. 1(3):186-192; 2007.
10. Blomeier, H.; Zhang, X.; Rives, C.; Brissova, M.; Hughes, E.; Baker, M.; Powers, A. C.; Kaufman, D. B.; Shea, L. D.; Lowe, W. L., Jr. Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation 82(4):452-459; 2006.
11. Buchwald, P.; Wang, X.; Khan, A.; Bernal, A.; Fraker, C.; Inverardi, L.; Ricordi, C. Quantitative assessment of islet cell products: Estimating the accuracy of the existing protocol and accounting for islet size distribution. Cell Transplant 18(10):1223-1235; 2009.
12. Calafiore, R. Actual perspectives in biohybrid artificial pancreas for the therapy of type 1, insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 14(4):315-324; 1998.
13. Calafiore, R.; Basta, G.; Falorni, A., Jr.; Ciabattoni, P.; Brotzu, G.; Cortesini, R.; Brunetti, P. Intravascular transplantation of microencapsulated islets in diabetic dogs. Transplant Proc. 24(3):935-936; 1992.
14. Calafiore, R.; Basta, G.; Luca, G.; Lemmi, A.; Montanucci, M. P.; Calabrese, G.; Racanicchi, L.; Mancuso, F.; Brunetti, P. Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: First two cases. Diabetes Care 29(1):137-138; 2006.
15. Chaikof, E. L. Engineering and material considerations in islet cell transplantation. Annu. Rev. Biomed. Eng. 1:103-127; 1999.
16. Colas, A.; Curtis, J. Medical Applications of Silicones. In: Ratner, B.; Hoffman, A.; Schoen, F.; Lemons, J., eds. Biomaterials Science, An Introduction to Materials in Medicine. Burlington: Elsevier; 2004:697-707.
17. Cox, M. E.; Dunn, B. Oxygen diffusion in poly(dimethyl siloxane) using fluorescence quenching. I. Measurement technique and analysis. J. Poly. Sci. A: Poly. Chem. 24(4): 621-636; 1986.
18. Cuthbertson, R. A.; Mandel, T. E. A comparison of portal versus systemic venous drainage in murine foetal pancreatic islet transplantation. Aust. J. Exp. Biol. Med. Sci. 64 (Pt 2): 175-184; 1986.
19. Daoud, J.; Petropavlovskaia, M.; Rosenberg, L.; Tabrizian, M. The effect of extracellular matrix components on the preservation of human islet function in vitro. Biomaterials 31(7):1676-1682; 2010.
20. De Vos, P.; Hamel, A. F.; Tatarkiewicz, K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 45(2):159-173; 2002.
21. Di Colo, G. Controlled drug release from implantable matrices based on hydrophobic polymers. Biomaterials 13(12):850-856; 1992.
22. Dufour, J. M.; Rajotte, R. V.; Zimmerman, M.; Rezania, A.; Kin, T.; Dixon, D. E.; Korbutt, G. S. Development of an ectopic site for islet transplantation, using biodegradable scaffolds. Tissue Eng. 11(9-10):1323-1331; 2005.
23. Fraker, C. The Role of Oxygen During In Vitro Culture and Immunoisolation of Islets of Langerhans. Biomedical Engineering. Miami: University of Miami; 2011:324.
24. Gibly, R. F.; Zhang, X.; Graham, M. L.; Hering, B. J.; Kaufman, D. B.; Lowe, W. L., Jr.; Shea, L. D. Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models. Biomaterials 32(36):9677-9684; 2011.
25. Guan, J.; Zucker, P. F.; Atkison, P.; Behme, M. T.; Dupre, J.; Stiller, C. R. Liver-omental pouch and intrahepatic islet transplants produce portal insulin delivery and prevent hyperinsulinemia in rats. Transplant Proc. 27(6):3236; 1995.
26. Gupta, R.; Sefton, M. V. Application of an endothelialized modular construct for islet transplantation in syngeneic and allogeneic immunosuppressed rat models. Tissue Eng. Part A 17(15-16):2005-2015; 2011.
27. Hall, K. K.; Gattas-Asfura, K. M.; Stabler, C. L. Microencapsulation of islets within alginate/poly(ethylene glycol) gels cross-linked via Staudinger ligation. Acta Biomater. 7(2): 614-624; 2011.
28. Hamamoto, Y.; Fujimoto, S.; Inada, A.; Takehiro, M.; Nabe, K.; Shimono, D.; Kajikawa, M.; Fujita, J.; Yamada, Y.; Seino, Y. Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation. Hormone and Metabolic Research 35(8):460-465; 2003.
29. Hesse, U. J.; Sutherland, D. E.; Gores, P. F.; Sitges-Serra, A.; Najarian, J. S. Comparison of splenic and renal subcapsular islet autografting in dogs. Transplantation 41(2):271-274; 1986.
30. Hou, Q. P.; Bae, Y. H. Biohybrid artificial pancreas based on macrocapsule device. Adv. Drug Deliv. Rev. 35(2-3): 271-287; 1999.
31. Johansson, H.; Lukinius, A.; Moberg, L.; Lundgren, T.; Berne, C.; Foss, A.; Felldin, M.; Kallen, R.; Salmela, K.; Tibell, A. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 54(6):1755-1762; 2005.
32. Johansson, U.; Elgue, G.; Nilsson, B.; Korsgen, O. Composite islet-endothelial cell grafts: A novel approach to counteract innate immunity in islet transplantation. Am. J. Trans. 5:2632-2639; 2005.
33. Johansson, U.; Olsson, A.; Gabrielsson, S.; Nilsson, B.; Korsgen, O. Inflammatory mediators expressed in human islets of Langerhans: Implications for islet transplantation. Biochem. Biophys. Res. Commun. 308:474-479; 2003.
34. Kaufman, D. B.; Morel, P.; Field, M. J.; Munn, S. R.; Sutherland, D. E. Purified canine islet autografts. Functional outcome as influenced by islet number and implantation site. Transplantation 50(3):385-391; 1990.
35. Khorasani, M. T.; Mirzadeh, H. Laser surface modification of silicone rubber to reduce platelet adhesion in vitro. J. Biomater. Sci. Polym. Ed. 15(1):59-72; 2004.
36. Kim, H. I.; Yu, J. E.; Park, C. G.; Kim, S. J. Comparison of four pancreatic islet implantation sites. J. Korean Med. Sci. 25(2):203-210; 2010.
37. Kin, T.; Korbutt, G. S.; Rajotte, R. V. Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch. Am. J. Transplant 3(3):281-285; 2003.
38. Kin, T.; O'Neil, J. J.; Pawlick, R.; Korbutt, G. S.; Shapiro, A. M.; Lakey, J. R. The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment. Artif. Organs 32(12):990-993; 2008.
39. Kobayashi, T.; Aomatsu, Y.; Iwata, H.; Kin, T.; Kanehiro, H.; Hisanga, M.; Ko, S.; Nagao, M.; Harb, G.; Nakajima, Y. Survival of microencapsulated islets at 400 days posttransplantation in the omental pouch of NOD mice. Cell Transplant. 15(4):359-365; 2006.
40. Kriz, J.; Vilk, G.; Mazzuca, D. M.; Toleikis, P. M.; Foster, P. J.; White, D. J. G. A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence. Am. J. Surg. epub; 2012.
41. Kuntz, E.; Kuntz, H.-D. Hepatology, Principles and Practice, 2nd ed. Germany: Springer; 2005.
42. Lacy, P. E.; Hegre, O. D.; Gerasimidi-Vazeou, A.; Gentile, F. T.; Dionne, K. E. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets. Science 254(5039):1782-1784; 1991.
43. Langer, R. Implantable controlled release systems. Pharmacol. Ther. 21(1):35-51; 1983.
44. Li, Y. X.; Li, G.; Dong, W. P.; Lu, D. R.; Tan, J. M. Protection of human islets from induction of apoptosis and improved islet function with HO-1 gene transduction. Chin. Med. J. (Engl) 119(19):1639-1645; 2006.
45. Liu, M.; Han, Z. C. Stem cells review series: Mesenchymal stem cells: Biology and clinical potential in type 1 diabetes therapy. J. Cell. Mol. Med. 12(4):1155-1168; 2008.
46. Martino, M. M.; Hubbell, J. A. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. Faseb J.; 2010.
47. Martino, M. M.; Tortelli, F.; Mochizuki, M.; Traub, S.; Ben- David, D.; Kuhn, G. A.; Muller, R.; Livne, E.; Eming, S. A.; Hubbell, J. A. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci. Transl. Med. 3(100):100ra189; 2011.
48. Mata, A.; Fleischman, A.; Roy, S. Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/ nanosystems. Biomed. MIcrodev. 7(4):281-293; 2005.
49. Mattsson, G.; Jansson, L.; Nordin, A.; Andersson, A.; Carlsson, P. O. Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver. Diabetes 53(4):948-954; 2004.
50. McQuilling, J. P.; Arenas-Herrera, J.; Childers, C.; Pareta, R. A.; Khanna, O.; Jiang, B.; Brey, E. M.; Farney, A. C.; Opara, E. C. New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch. Transplantation Proceedings 43(9):3262-3264; 2011.
51. Mineo, D.; Pileggi, A.; Alejandro, R.; Ricordi, C. Point: Steady progress and current challenges in clinical islet transplantation. Diabetes Care 32(8):1563-1569; 2009.
52. Moberg, L.; Johansson, H.; Lukinius, A.; Berne, C.; Foss, A.; Kallen, R.; Ostraat, O.; Salmela, K.; Tibell, A.; Tufveson, G. Productions of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 360:2039-2045; 2002.
53. Molano, R. D.; Berney, T.; Li, H.; Cattan, P.; Pileggi, A.; Vizzardelli, C.; Kenyon, N. S.; Ricordi, C.; Burkly, L. C.; Inverardi, L. Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation. Diabetes 50(2):270-276; 2001.
54. Nishikawa, M.; Yamamoto, T.; Kojima, N.; Kikuo, K.; Fujii, T.; Sakai, Y. Stable immobilization of rat hepatocytes as hemispheroids onto collagen-conjugated polydimethylsiloxane (PDMS) surfaces: Importance of direct oxygenation through PDMS for both formation and function. Biotech. Bioeng. 99(6):1472-1481; 2008.
55. Ohgawara, H.; Hirotani, S.; Miyazaki, J.; Teraoka, S. Membrane immunoisolation of a diffusion chamber for bioartificial pancreas. Artif. Organs 22(9):788-794; 1998.
56. Paraskevas, S.; Maysinger, D.; Wang, R.; Duguid, T. P.; Rosenberg, L. Cell loss in isolated human islets occurs by apoptosis. Pancreas 20(3):270-276; 2000.
57. Pedraza, E.; Coronel, M.; Fraker, C.; Ricordi, C.; Stabler, C. Enhancing β-cell viability via hydrolytically activated, oxygen generating biomaterials. Proc. Natl. Acad. Sci. USA 109(11):4245-4250; 2012.
58. Pileggi, A.; Molano, R. D.; Ricordi, C.; Zahr, E.; Collins, J.; Valdes, R.; Inverardi, L. Reversal of diabetes by pancreatic islet transplantation into a subcutaneous, neovascularized device. Transplantation 81(9):1318-1324; 2006.
59. Robertson, R. P. Intrahepatically transplanted islets-strangers in a strange land. J. Clin. Endocrinol. Metab. 87(12):5416-5417; 2002.
60. Roth, J.; Albrecht, V.; Nitschke, M.; Bellmann, C.; Simon, F.; Zschoche, S.; Michel, S.; Luhmann, C.; Grundke, K.; Voit, B. Surface functionalization of silicone rubber for permanent adhesion improvement. Langmuir 24(21):12603-12611; 2008.
61. Salvay, D.; Rives, C.; Zhang, X.; Chen, F.; Kaufman, D. B.; Lowe, W. L., Jr.; Shea, L. D. Extracellular matrix proteincoated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation 85(10): 1456-1464; 2008.
62. Shapiro, A. M.; Ricordi, C.; Hering, B. J.; Auchincloss, H.; Lindblad, R.; Robertson, R. P.; Secchi, A.; Brendel, M. D.; Berney, T.; Brennan, D. C. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355(13):1318-1330; 2006.
63. Sigrist, S.; Mechine-Neuville, A.; Mandes, K.; Calenda, V.; Legeay, G.; Bellocq, J. P.; Pinget, M.; Kessler, L. Induction of angiogenesis in omentum with vascular endothelial growth factor: Influence on the viability of encapsulated rat pancreatic islets during transplantation. J. Vasc. Res. 40(4):359-367; 2003.
64. Silva, A.; de Matos, A.; Brons, I.; Mateus, M. An overview on the development of a bioartificial pancreas as a treatment of insulin-dependent diabetes mellitus. Med. Res. Rev. 26(2):181-222; 2006.
65. Silva, A.; Mateus, M. Development of a polysulfone hollow fiber vascular bioartificial pancreas device for in vitro studies. J. Biotech. 139(3):236-249; 2009.
66. Storrs, R.; Dorian, R.; King, S. R.; Lakey, J.; Rilo, H. Preclinical development of the Islet Sheet. Ann. NY Acad. Sci. 944:252-266; 2001.
67. Sun, A. M. Microencapsulation of pancreatic islet cells: A bioartificial endocrine pancreas. Methods Enzymol. 137: 575-580; 1988.
68. Toworfe, G. K.; Composto, R. J.; Adams, C. S.; Shapiro, I. M.; Ducheyne, P. Fibronectin adsorption on surfaceactivated poly(dimethylsiloxane) and its effect on cellular function. Biomed. Mater. Res. A 71A(3):449-461; 2004.
69. van der Windt, D. J.; Bottino, R.; Casu, A.; Campanile, N.; Cooper, D. K. Rapid loss of intraportally transplanted islets: An overview of pathophysiology and preventive strategies. Xenotransplantation 14(4):288-297; 2007.
70. Warnock, G. L.; Dabbs, K. D.; Evans, M. G.; Cattral, M. S.; Kneteman, N. M.; Rajotte, R. V. Critical mass of islets that function after implantation in a large mammalian. Horm. Metab. Res. Suppl. 25:156-161; 1990.
71. Warnock, G. L.; Rajotte, R. V. Pancreatic islet cell transplantation: A new era in transplantation. Can. Fam. Physician 38:1655-1660; 1992.
72. White, S. A.; Davies, J. E.; Pollard, C.; Swift, S. M.; Clayton, H. A.; Sutton, C. D.; Weymss-Holden, S.; Musto, P. P.; Berry, D. P.; Dennison, A. R. Pancreas resection and islet autotransplantation for end-stage chronic pancreatitis. Ann. Surg. 233(3):423-431; 2001.
73. White, S. A.; London, N. J.; Johnson, P. R.; Davies, J. E.; Pollard, C.; Contractor, H. H.; Hughes, D. P.; Robertson, G. S.; Musto, P. P.; Dennison, A. R. The risks of total pancreatectomy and splenic islet autotransplantation. Cell Transplant 9(1):19-24; 2000.
74. Yang, H.; Iwata, J.; Shimizu, H.; Takagi, T.; Tsuji, T.; Ito, F. Comparative studies of in vitro and in vivo function of three different shaped bioartificial pancreases made of agarose hydrogel. Biomaterials 15(2):113-120; 1994.
75. Yang, Z.; Chen, M.; Carter, J.; Ellett, J.; Smith, K.; Nadler, J. Inflammation blockade improves pancreatic islet function. Transplant Proc. 36:2864-2865; 2004.
76. Yasunami, Y.; Lacy, P. E.; Finke, E. H. A new site for islet transplantation-a peritoneal-omental pouch. Transplantation 36(2):181-182; 1983.