Synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines from 4,6-dichloropyrimidine-5-carboxaldehyde: Insights into selectivity and reactivity

Synthesis (Germany)

Volumn 45, Issue 13, 2013, Pages 1791-1806

  Morrill, Christie ^a   Babu, Suresh ^a   Almstead, Neilg ^a   Moon, Young Choon ^a  

^a PTC THERAPEUTICS   (United States)

Author keywords

condensation; hydrazines; hydrazones; nucleophilic aromatic substitution; pyrazolo 3,4 d pyrimidines

Indexed keywords

FUNCTIONALIZATIONS; HYDRAZONES; NUCLEOPHILIC AROMATIC SUBSTITUTION; PYRAZOLO[3,4- D ]PYRIMIDINES; RAPID GENERATIONS; REACTION MECHANISM; REACTIVITY TRENDS; SYNTHETIC INTERMEDIATES;

AROMATIZATION; CHLORINE COMPOUNDS; CONDENSATION; HYDRAZINE;

AROMATIC COMPOUNDS;

4,6 DICHLOROPYRIMIDINE 5 CARBOXYALDEHYDE; ALDEHYDE DERIVATIVE; HYDRAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; CYCLIZATION; ELIMINATION REACTION; HEATING; HIGH TEMPERATURE; MICROWAVE IRRADIATION; NUCLEOPHILICITY; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; SUBSTITUTION REACTION;

EID: 84879508101     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0033-1338862     Document Type: Article

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