Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis

Cell Stress and Chaperones

Volumn 18, Issue 4, 2013, Pages 483-493

  Leng, Xue ^b   Wang, Xinxing ^a   Pang, Wei ^c   Zhan, Rui ^a   Zhang, Zhiqing ^c   Wang, Liqun ^c   Gao, Xiujie ^c   Qian, Lingjia ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b Institute of Medical Equipment   (China)

^c INSTITUTE OF HEALTH AND ENVIRONMENTAL MEDICINE   (China)

Author keywords

Anti Hsp70 antibody; Atherosclerosis; Endothelial cell; OxLDL; Surface membrane Hsp70

Indexed keywords

ALPHA ACTIN; AUTOANTIBODY; BLOOD CLOTTING FACTOR 8; CD3 ANTIGEN; CHROMIUM 51; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; OXIDIZED LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; ATHEROSCLEROSIS; CELL LABELING; CELL MEMBRANE; CELL SURFACE; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOCHEMISTRY; CYTOTOXICITY; DISEASE MODEL; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMORAL IMMUNITY; INCUBATION TIME; MALE; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SUPERNATANT;

ACTINS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ATHEROSCLEROSIS; AUTOANTIBODIES; CELL MEMBRANE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FACTOR VIII; HSP70 HEAT-SHOCK PROTEINS; LIPOPROTEINS, LDL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84879499618     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-013-0404-4     Document Type: Article

References (40)

1. Arispe N, Doh M, De Maio A (2002) Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70. Cell Stress Chaperones 7:330-338
2. Arispe N, Doh M, Simakova O, Kurganov B, De Maio A (2004) Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability. FASEB J 18:1636-1645
3. Bauer HC, Hurtenbach U (1986) Murine cortical brain cells are autoantigenic from a distinct developmental stage onwards. J Neuroimmunol 12:1-13
4. Cai GJ, Miao CY, Xie HH, Lu LH, Su DF (2005) Arterial baroreflex dysfunction promotes atherosclerosis in rats. Atherosclerosis 183:41-47
5. Campisi J, Leem TH, Fleshner M (2003) Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system. Cell Stress Chaperones 8:272-286
6. Chan YCSN, Abdus-Samee M et al (1999) Anti-heat-shock protein 70 kDa antibodies in vascular patients. Eur J Vasc Endovasc Surg 18:381-385
7. Dulin E, Garcia-Barreno P, Guisasola MC (2010) Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population. Cell Stress Chaperones 15:929-937
8. Enomoto Y, Bharti A, Khaleque AA, Song B, Liu C, Apostolopoulos V, Xing PX, Calderwood SK, Gong J (2006) Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells. J Immunol 177:5946-5955
9. Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, De Maio A, Pockley G, Multhoff G (2008) Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. PLoS One 3:e1925
10. George J, Greenberg S, Barshack I, Singh M, Pri-Chen S, Laniado S, Keren G (2001) Accelerated intimal thickening in carotid arteries of balloon-injured rats after immunization against heat shock protein 70. J Am Coll Cardiol 38:1564-1569
11. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914:66-73
12. Hightower LE, Guidon PT Jr (1989) Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 138:257-266
13. Huber LA, Scheffler E, Poll T, Ziegler R, Dresel HA (1990) 17 beta-estradiol inhibits LDL oxidation and cholesteryl ester formation in cultured macrophages. Free Radic Res Commun 8:167-173
14. Jialal I, Devaraj S (1996) The role of oxidized low density lipoprotein in atherogenesis. J Nutr 126:1053S-1057S
15. Jurgens G, Xu QB, Huber LA, Bock G, Howanietz H, Wick G, Traill KN (1989) Promotion of lymphocyte growth by high density lipoproteins (HDL). Physiological significance of the HDL binding site. J Biol Chem 264:8549-8556
16. Kocsis J, Veres A, Vatay A, Duba J, Karadi I, Fust G, Prohaszka Z (2002) Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease. Immunol Investig 31:219-231
17. Kreisel D, Krupnick AS, Szeto WY, Popma SH, Sankaran D, Krasinskas AM, Amin KM, Rosengard BR (2001) A simple method for culturing mouse vascular endothelium. J Immunol Methods 254:31-45
18. Leng X, Zhan R, Wang Y, Liu X, Gong J, Gao X, Wu L, Wang L, Zhao Y, Wang X, Zhang Z, Pang W, Qian LJ (2010) Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats. Cell Stress Chaperones 15:947-958
19. Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Q, Wick G (1999) Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation 99:1560-1566
20. Multhoff G, Hightower LE (1996) Cell surface expression of heat shock proteins and the immune response. Cell Stress Chaperones 1:167-176
21. Muscari A, Bozzoli C, Gerratana C, Zaca F, Rovinetti C, Zauli D, La Placa M, Puddu P (1988) Association of serum IgA and C4 with severe atherosclerosis. Atherosclerosis 74:179-186
22. Pockley A, De U, Kiessling R, Lemne C, Thulin T, Frostegård J (2002) Circulating heat shock protein and heat shock protein antibody levels in established hypertension. J Hypertens 20(9):1815-20
23. Pockley AG, Georgiades A, Thulin T et al (2003) Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension. Hypertension 42:235-238
24. Prohaszka Z, Duba J, Horvath L, Csaszar A, Karadi I, Szebeni A, Singh M, Fekete B, Romics L, Fust G (2001) Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects. Eur J Clin Investig 31:285-292
25. Salonen JT, Yla-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssonen K, Palinski W, Witztum JL (1992) Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 339:883-887
26. Sanson M, Auge N, Vindis C, Muller C, Bando Y, Thiers JC, Marachet MA, Zarkovic K, Sawa Y, Salvayre R, Negre-Salvayre A (2009) Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res 104:328-336
27. Schett G, Xu Q, Amberger A, Van der Zee R, Recheis H, Willeit J, Wick G (1995) Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest 96(6):2569-2577
28. Singh-Jasuja H, Hilf N, Arnold-Schild D, Schild H (2001) The role of heat shock proteins and their receptors in the activation of the immune system. Biol Chem 382:629-636
29. Srivastava P (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2:185-194
30. Triantafilou M, Miyake K, Golenbock DT, Triantafilou K (2002) Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 115:2603-2611
31. Vasankari T, Ahotupa M, Toikka J, Mikkola J, Irjala K, Pasanen P, Neuvonen K, Raitakari O, Viikari J (2001) Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy. Atherosclerosis 155:403-412
32. Wick G, Knoflach M, Xu Q (2004) Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev Immunol 22:361-403
33. Xu Q, Schett G, Seitz CS, Hu Y, Gupta RS, Wick G (1994) Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells. Circ Res 75:1078-1085
34. Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, Wick G (1999) Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis: clinical significance determined in a follow-up study. Circulation 100:1169-1174
35. Xu Q (2002) Role of heat shock proteins in atherosclerosis. Arterioscler Thromb Vasc Biol 22:1547-1559
36. Yuan J, Yang M, Yao H, Zheng J, Yang Q, Chen S, Wei Q, Tanguay RM, Wu T (2005) Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise. Cell Stress Chaperones 10:126-135
37. Zhang X, Tanguay RM, He M, Deng Q, Miao X, Zhou L, Wu T (2011) Variants of HSPA1A in combination with plasma Hsp70 and anti-Hsp70 antibody levels associated with higher risk of acute coronary syndrome. Cardiology 119:57-64
38. Zhu J, Quyyumi AA, Wu H, Csako G, Rott D, Zalles-Ganley A, Ogunmakinwa J, Halcox J, Epstein SE (2003) Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease. Arterioscler Thromb Vasc Biol 23:1055-1059
39. Zhu J, Katz RJ, Quyyumi AA, Canos DA, Rott D, Csako G, Zalles-Ganley A, Ogunmakinwa J, Wasserman AG, Epstein SE (2004) Association of serum antibodies to heat-shock protein 65 with coronary calcification levels: suggestion of pathogen-triggered autoimmunity in early atherosclerosis. Circulation 109:36-41
40. Zhu W, Roma E, Pellegatta F, Catapano AL (1994) Biochem Biophys Res Commun 200:389-394 Projects