Vitamin D deficiency is associated with ulcerative colitis disease activity

Digestive Diseases and Sciences

Volumn 58, Issue 6, 2013, Pages 1698-1702

  Blanck, Stacey ^a   Aberra, Faten ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Inflammatory bowel disease; Ulcerative colitis; Vitamin D; Vitamin D deficiency

Indexed keywords

25 HYDROXYVITAMIN D; ADALIMUMAB; INFLIXIMAB; MERCAPTOPURINE; STEROID; VITAMIN D;

ADULT; ARTICLE; CHI SQUARE DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ELECTRONIC MEDICAL RECORD; FEMALE; GASTROENTEROLOGY; HEALTH CARE; HUMAN; HYPOTHESIS; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

ADULT; AGED; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; COLITIS, ULCERATIVE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84879498078     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2531-7     Document Type: Article

References (19)

1. Kappelman MD, Rifas-Shiman SL, Kleinman K, et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007;5:1424-1429.
2. Ardizzone S, Cassinotti A, Trabattoni D, et al. Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. Int J Immunopathol Pharmacol. 2009;22:63-71.
3. Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. 2006;92:60-64.
4. Lim WC, Hanauer SB, Li YC. Mechanisms of disease: vitamin D and inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2005;2:308-315.
5. Cantorna MT. Why do T cells express the vitamin D receptor? Ann NY Acad Sci. 2011;1217:77-82.
6. Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol. 2010;37:491-495.
7. Cantorna MT, Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med. 2000;223:230-233.
8. Szodoray P, Nakken B, Gaal J, et al. The complex role of vitamin D in autoimmune diseases. Scand J Immunol. 2008;68:261-269.
9. Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004;229:1136-1142.
10. Pappa HM, Grand RJ, Gordon CM. Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease. Inflamm Bowel Dis. 2006;12:1162-1174.
11. Ananthakrishnan AN, Khalili H, Higuchi LM, et al. Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Gastroenterology. 2012;142:482-489.
12. Jorgensen SP, Agnholt J, Glerup H, et al. Clinical trial: vitamin D3 treatment in Crohn's disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010;32:377-383.
13. Ulitsky A, Ananthakrishnan AN, Naik A, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011;35:308-316.
14. Lewis JD, Chuai S, Nessel L, et al. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis. 2008;14:1660-1666.
15. Cantorna MT, Zhu Y, Froicu M, et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717S-1720S.
16. Holick MF. Vitamin D deficiency: what a pain it is. Mayo Clin Proc. 2003;78:1457-1459.
17. Cantorna MT, Munsick C, Bemiss C, et al. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr. 2000;130:2648-2652.
18. Dresner-Pollak R, Ackerman Z, Eliakim R, et al. The BsmI vitamin D receptor gene polymorphism is associated with ulcerative colitis in Jewish Ashkenazi patients. Genet Test. 2004;8:417-420.
19. Schoon EJ, Blok BM, Geerling BJ, et al. Bone mineral density in patients with recently diagnosed inflammatory bowel disease. Gastroenterology. 2000;119:1203-1208.