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Volumn 8, Issue 6, 2013, Pages

Increased Erythrocytes By-Products of Arginine Catabolism Are Associated with Hyperglycemia and Could Be Involved in the Pathogenesis of Type 2 Diabetes Mellitus

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; ARGININE; CARBON 14; CITRULLINE; GLUCOSE; HEMOGLOBIN A1C; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; ORNITHINE; UREA;

EID: 84879497287     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066823     Document Type: Article
Times cited : (37)

References (58)
  • 1
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, Shaw J, (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 2
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW, (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-411.
    • (1991) Diabetes , vol.40 , pp. 405-411
    • Baynes, J.W.1
  • 4
    • 0036192815 scopus 로고    scopus 로고
    • Lipid peroxidation, some extracellular antioxidant enzymes in serum of patients with rheumatoid arthritis
    • Taysi S, Polat F, Gul M, Sari RA, Bakan E, (2002) Lipid peroxidation, some extracellular antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int 21: 200-204.
    • (2002) Rheumatol Int , vol.21 , pp. 200-204
    • Taysi, S.1    Polat, F.2    Gul, M.3    Sari, R.A.4    Bakan, E.5
  • 5
    • 0033744268 scopus 로고    scopus 로고
    • Arginine nutrition and cardiovascular function
    • Wu G, Meininger CJ, (2000) Arginine nutrition and cardiovascular function. J Nutr 130: 2626-2629.
    • (2000) J Nutr , vol.130 , pp. 2626-2629
    • Wu, G.1    Meininger, C.J.2
  • 6
    • 0025096104 scopus 로고
    • Auto oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
    • Hunt JV, Smith CC, Wolff SP, (1990) Auto oxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39: 1420-1424.
    • (1990) Diabetes , vol.39 , pp. 1420-1424
    • Hunt, J.V.1    Smith, C.C.2    Wolff, S.P.3
  • 7
    • 0017193387 scopus 로고
    • Red cell age-related changes of hemoglobin AIa+b and AIc in normal and diabetic subjects
    • Fitzgibbons JF, Koler RD, Jones RT, (1976) Red cell age-related changes of hemoglobin AIa+b and AIc in normal and diabetic subjects. J Clin Invest 58: 820-824.
    • (1976) J Clin Invest , vol.58 , pp. 820-824
    • Fitzgibbons, J.F.1    Koler, R.D.2    Jones, R.T.3
  • 8
    • 0035078318 scopus 로고    scopus 로고
    • Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins
    • Abuja PM, Albertini R, (2001) Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin Chim Acta 306: 1-17.
    • (2001) Clin Chim Acta , vol.306 , pp. 1-17
    • Abuja, P.M.1    Albertini, R.2
  • 9
    • 36348954532 scopus 로고    scopus 로고
    • Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma
    • Paroni R, Ceriotti F, Galanello R, Battista LG, Panico A, et al. (2007) Performance characteristics and clinical utility of an enzymatic method for the measurement of glycated albumin in plasma. Clin Biochem 40: 1398-1405.
    • (2007) Clin Biochem , vol.40 , pp. 1398-1405
    • Paroni, R.1    Ceriotti, F.2    Galanello, R.3    Battista, L.G.4    Panico, A.5
  • 10
    • 0027229692 scopus 로고
    • Lipid peroxidation and trace elements status in diabetic ketotic patients: influence of insulin therapy
    • Faure P, Corticelli P, Richard MJ, Arnaud K, Coudray C, et al. (1993) Lipid peroxidation and trace elements status in diabetic ketotic patients: influence of insulin therapy. Clin Chem 39: 789-793.
    • (1993) Clin Chem , vol.39 , pp. 789-793
    • Faure, P.1    Corticelli, P.2    Richard, M.J.3    Arnaud, K.4    Coudray, C.5
  • 12
    • 33746941255 scopus 로고    scopus 로고
    • Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
    • Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G, (2006) Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem 17: 571-588.
    • (2006) J Nutr Biochem , vol.17 , pp. 571-588
    • Jobgen, W.S.1    Fried, S.K.2    Fu, W.J.3    Meininger, C.J.4    Wu, G.5
  • 14
    • 33745039466 scopus 로고    scopus 로고
    • Nitric oxide, cell bioenergetics and neurodegeneration
    • Moncada S, Bolaños JP, (2006) Nitric oxide, cell bioenergetics and neurodegeneration. J Neurochem 97: 1676-1689.
    • (2006) J Neurochem , vol.97 , pp. 1676-1689
    • Moncada, S.1    Bolaños, J.P.2
  • 15
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: nitric oxide and beyond
    • Wu G, Morris Jr SM, (1998) Arginine metabolism: nitric oxide and beyond. Biochem J 336: 1-17.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris Jr., S.M.2
  • 16
    • 1542347165 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats
    • Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, et al. (2004) Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J Nutr 134: 600-608.
    • (2004) J Nutr , vol.134 , pp. 600-608
    • Kohli, R.1    Meininger, C.J.2    Haynes, T.E.3    Yan, W.4    Self, J.T.5
  • 17
    • 67349147426 scopus 로고    scopus 로고
    • Arginine metabolism and nutrition in growth, health and disease
    • Wu G, Bazer FW, Davis TA, King SW, Li P, et al. (2009) Arginine metabolism and nutrition in growth, health and disease. Amino Acids 37: 153-168.
    • (2009) Amino Acids , vol.37 , pp. 153-168
    • Wu, G.1    Bazer, F.W.2    Davis, T.A.3    King, S.W.4    Li, P.5
  • 18
    • 0016256203 scopus 로고
    • Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas
    • Gerich JE, Charles MA, Grodsky GM, (1974) Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest 54: 833-841.
    • (1974) J Clin Invest , vol.54 , pp. 833-841
    • Gerich, J.E.1    Charles, M.A.2    Grodsky, G.M.3
  • 19
    • 34249788716 scopus 로고    scopus 로고
    • Arginine metabolism: boundaries of our knowledge
    • Morris Jr SM, (2007) Arginine metabolism: boundaries of our knowledge. J Nutr 137: 1602S-1609S.
    • (2007) J Nutr , vol.137
    • Morris Jr., S.M.1
  • 23
    • 37849019273 scopus 로고    scopus 로고
    • Diabetes-induced coronary vascular dysfunction involves arginase activity
    • Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, et al. (2008) Diabetes-induced coronary vascular dysfunction involves arginase activity. Circ Res 102: 95-102.
    • (2008) Circ Res , vol.102 , pp. 95-102
    • Romero, M.J.1    Platt, D.H.2    Tawfik, H.E.3    Labazi, M.4    El-Remessy, A.B.5
  • 26
    • 0002457668 scopus 로고
    • Ornithine carbamoyl transferase
    • In: Bergmeyer HU, Bergmeyer J, Grassl M, editors, Deerfield Beach, Florida: Verlag Chemie
    • Ceriotti G (1983) Ornithine carbamoyl transferase. In: Bergmeyer HU, Bergmeyer J, Grassl M, editors. Methods of Enzymatic Analysis. Deerfield Beach, Florida: Verlag Chemie. 319-332.
    • (1983) Methods of Enzymatic Analysis , pp. 319-332
    • Ceriotti, G.1
  • 27
    • 0014118789 scopus 로고
    • A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids
    • Gaitonde MK, (1967) A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem J 104: 627-633.
    • (1967) Biochem J , vol.104 , pp. 627-633
    • Gaitonde, M.K.1
  • 29
    • 0000277162 scopus 로고
    • Arginine and arginine phosphate
    • In: Bergmeyer HU, Bergmeyer J, Grassl M, editors, Deerfield Beach, Florida: Verlag Chemie
    • Gäde G (1983) Arginine and arginine phosphate. In: Bergmeyer HU, Bergmeyer J, Grassl M, editors. Methods of Enzymatic Analysis. Deerfield Beach, Florida: Verlag Chemie. 425-431.
    • (1983) Methods of Enzymatic Analysis , pp. 425-431
    • Gäde, G.1
  • 30
    • 0002774186 scopus 로고
    • Urea
    • In: Bergmeyer HU, Bergmeyer J, Grassl M, editors, Deerfield Beach, Florida: Verlag Chemie
    • Kerscher L, Ziegenhorn J (1983) Urea. In: Bergmeyer HU, Bergmeyer J, Grassl M, editors. Methods of Enzymatic Analysis. Deerfield Beach, Florida: Verlag Chemie. 444-453.
    • (1983) Methods of Enzymatic Analysis , pp. 444-453
    • Kerscher, L.1    Ziegenhorn, J.2
  • 31
    • 0015014407 scopus 로고
    • Simplified thin layer chromatography screening test for detection of important hyperaminoacidemias
    • Kraffczyk F, Helger R, Lang H, (1971) Simplified thin layer chromatography screening test for detection of important hyperaminoacidemias. Clin Chim Acta 31: 489-491.
    • (1971) Clin Chim Acta , vol.31 , pp. 489-491
    • Kraffczyk, F.1    Helger, R.2    Lang, H.3
  • 32
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, et al. (2011) Metabolite profiles and the risk of developing diabetes. Nat Med 17: 448-453.
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3    Cheng, S.4    Rhee, E.P.5
  • 33
    • 82055171984 scopus 로고    scopus 로고
    • Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial
    • Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, et al. (2011) Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med 9: 125.
    • (2011) BMC Med , vol.9 , pp. 125
    • Shab-Bidar, S.1    Neyestani, T.R.2    Djazayery, A.3    Eshraghian, M.R.4    Houshiarrad, A.5
  • 34
    • 0029029055 scopus 로고
    • Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus
    • Griesmacher A, Kindhauser M, Andert SE, Schreiner W, Toma C, et al. (1995) Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus. Am J Med 98: 469-475.
    • (1995) Am J Med , vol.98 , pp. 469-475
    • Griesmacher, A.1    Kindhauser, M.2    Andert, S.E.3    Schreiner, W.4    Toma, C.5
  • 35
    • 80053460459 scopus 로고    scopus 로고
    • Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: involvement of advanced glycosylated end products
    • Remor AP, de Matos FJ, Ghisoni K, da Silva TL, Eidt G, et al. (2011) Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: involvement of advanced glycosylated end products. Biochim Biophys Acta 1812: 1460-1471.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 1460-1471
    • Remor, A.P.1    de Matos, F.J.2    Ghisoni, K.3    da Silva, T.L.4    Eidt, G.5
  • 36
    • 0030048496 scopus 로고    scopus 로고
    • Oxidative stress and diabetic vascular complications
    • Giugliano D, Ceriello A, Paolisso G, (1996) Oxidative stress and diabetic vascular complications. Diabetes Care 19: 257-267.
    • (1996) Diabetes Care , vol.19 , pp. 257-267
    • Giugliano, D.1    Ceriello, A.2    Paolisso, G.3
  • 37
    • 0023680343 scopus 로고
    • Oxidative stresses induced the cystine transport activity in human erythrocytes
    • Ohtsuka Y, Kondo T, Kawakami Y, (1988) Oxidative stresses induced the cystine transport activity in human erythrocytes. Biochem Biophys Res Commun 155: 160-166.
    • (1988) Biochem Biophys Res Commun , vol.155 , pp. 160-166
    • Ohtsuka, Y.1    Kondo, T.2    Kawakami, Y.3
  • 38
    • 11144262141 scopus 로고    scopus 로고
    • Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells
    • Srinivasan S, Hatley ME, Bolick DT, Palmer LA, Edelstein D, et al. (2004) Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia 47: 1727-1734.
    • (2004) Diabetologia , vol.47 , pp. 1727-1734
    • Srinivasan, S.1    Hatley, M.E.2    Bolick, D.T.3    Palmer, L.A.4    Edelstein, D.5
  • 40
    • 0020456430 scopus 로고
    • Measurement of arginine transport in human erythrocytes using their intrinsic arginase activity: implications for the treatment of familial hyperargininemia
    • Van Broeckhoven CL, Adriaenssens KM, Marescau B, Pintens J, Terheggen HG, (1982) Measurement of arginine transport in human erythrocytes using their intrinsic arginase activity: implications for the treatment of familial hyperargininemia. Clin Chim Acta 126: 209-216.
    • (1982) Clin Chim Acta , vol.126 , pp. 209-216
    • Van Broeckhoven, C.L.1    Adriaenssens, K.M.2    Marescau, B.3    Pintens, J.4    Terheggen, H.G.5
  • 41
    • 0031785961 scopus 로고    scopus 로고
    • Erythrocytes participate significantly in blood transport of amino acids during the post absorptive state in normal humans
    • Agli AN, Schaefer A, Geny B, Piquard F, Haberey P, (1998) Erythrocytes participate significantly in blood transport of amino acids during the post absorptive state in normal humans. Eur J Appl Physiol Occup Physiol 78: 502-508.
    • (1998) Eur J Appl Physiol Occup Physiol , vol.78 , pp. 502-508
    • Agli, A.N.1    Schaefer, A.2    Geny, B.3    Piquard, F.4    Haberey, P.5
  • 42
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S, (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 43
    • 0020662893 scopus 로고
    • Effect of experimental diabetes on the levels of aromatic and branched-chain amino acids in rat blood and brain
    • Crandall EA, Fernstrom JD, (1983) Effect of experimental diabetes on the levels of aromatic and branched-chain amino acids in rat blood and brain. Diabetes 32: 222-230.
    • (1983) Diabetes , vol.32 , pp. 222-230
    • Crandall, E.A.1    Fernstrom, J.D.2
  • 44
    • 27844530581 scopus 로고    scopus 로고
    • Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end products but not glucose: relevance to diabetes
    • Xu B, Ji Y, Yao K, Cao YX, Ferro A, (2006) Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end products but not glucose: relevance to diabetes. Clin Sci 119: 439-446.
    • (2006) Clin Sci , vol.119 , pp. 439-446
    • Xu, B.1    Ji, Y.2    Yao, K.3    Cao, Y.X.4    Ferro, A.5
  • 45
    • 0019126972 scopus 로고
    • Biochemical changes during reticulocyte maturation in culture. A comparison of genetically different sheep erythrocytes
    • Tucker EM, Young JD, (1980) Biochemical changes during reticulocyte maturation in culture. A comparison of genetically different sheep erythrocytes. Biochem J 192: 33-39.
    • (1980) Biochem J , vol.192 , pp. 33-39
    • Tucker, E.M.1    Young, J.D.2
  • 46
    • 0015860095 scopus 로고
    • Evidence of inter-organ amino acid that RBC and plasma play independent and frequently transport by blood cells in humans
    • Felig P, Wahren J, Räf L, (1973) Evidence of inter-organ amino acid that RBC and plasma play independent and frequently transport by blood cells in humans. Proc Natl Acad Sci USA 70: 1775-1779.
    • (1973) Proc Natl Acad Sci USA , vol.70 , pp. 1775-1779
    • Felig, P.1    Wahren, J.2    Räf, L.3
  • 47
    • 0020201899 scopus 로고
    • Interorgan amino acid nutrition
    • Christensen HN, (1982) Interorgan amino acid nutrition. Physiol Rev 62: 1193-1233.
    • (1982) Physiol Rev , vol.62 , pp. 1193-1233
    • Christensen, H.N.1
  • 48
    • 0024991203 scopus 로고
    • A study of the membrane transport of amino acids in erythrocytes from patients on haemodialysis
    • Fervenza FC, Meredith D, Ellory JC, Hendry BM, (1990) A study of the membrane transport of amino acids in erythrocytes from patients on haemodialysis. Nephrol Dial Transplant 5: 594-599.
    • (1990) Nephrol Dial Transplant , vol.5 , pp. 594-599
    • Fervenza, F.C.1    Meredith, D.2    Ellory, J.C.3    Hendry, B.M.4
  • 49
    • 0028149216 scopus 로고
    • Polyamine transport and arginine pool size in vascular endothelial cells
    • Morgan DML, Baydoun AR, (1994) Polyamine transport and arginine pool size in vascular endothelial cells. Biochem Soc Transact 22: 387S.
    • (1994) Biochem Soc Transact , vol.22
    • Morgan, D.M.L.1    Baydoun, A.R.2
  • 50
    • 0025018196 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine
    • Hecker M, Sessa WC, Harris HJ, Anggard EE, Vane JR, (1990) The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci USA 87: 8612-8616.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8612-8616
    • Hecker, M.1    Sessa, W.C.2    Harris, H.J.3    Anggard, E.E.4    Vane, J.R.5
  • 51
    • 0028786948 scopus 로고
    • Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans
    • Beaumier L, Castillo L, Ajami AM, Young VR, (1995) Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans. Am J Physiol Endocrinol Metab 269: E884-E896.
    • (1995) Am J Physiol Endocrinol Metab , vol.269
    • Beaumier, L.1    Castillo, L.2    Ajami, A.M.3    Young, V.R.4
  • 52
    • 33645532445 scopus 로고    scopus 로고
    • Red blood cells express a functional endothelial nitric oxide synthase
    • Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, et al. (2006) Red blood cells express a functional endothelial nitric oxide synthase. Blood 2006 107: 2943-2951.
    • (2006) Blood 2006 , vol.107 , pp. 2943-2951
    • Kleinbongard, P.1    Schulz, R.2    Rassaf, T.3    Lauer, T.4    Dejam, A.5
  • 53
    • 32044435163 scopus 로고    scopus 로고
    • Role of polyamines derived from arginine in differentiation and proliferation of human blood cells
    • Maeda T, Wakasawa T, Shima Y, Tsuboi I, Aizawa S, (2006) Role of polyamines derived from arginine in differentiation and proliferation of human blood cells. Biol Pharm Bull 29: 234-239.
    • (2006) Biol Pharm Bull , vol.29 , pp. 234-239
    • Maeda, T.1    Wakasawa, T.2    Shima, Y.3    Tsuboi, I.4    Aizawa, S.5
  • 54
    • 0029031584 scopus 로고
    • Kidd blood group and urea transport function of human erythrocytes are carried by the same protein
    • Olivès B, Mattei MG, Huet M, Neau P, Martial S, et al. (1995) Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. J Biol Chem 270: 15607-15610.
    • (1995) J Biol Chem , vol.270 , pp. 15607-15610
    • Olivès, B.1    Mattei, M.G.2    Huet, M.3    Neau, P.4    Martial, S.5
  • 55
    • 21444441271 scopus 로고    scopus 로고
    • Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    • Morris CR, Kato GJ, Poijakovic M, Wang X, Blackwelder WC, et al. (2005) Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA 294: 81-90.
    • (2005) JAMA , vol.294 , pp. 81-90
    • Morris, C.R.1    Kato, G.J.2    Poijakovic, M.3    Wang, X.4    Blackwelder, W.C.5
  • 56
    • 0035490032 scopus 로고    scopus 로고
    • Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results
    • Waugh WH, Daeschner 3rd CW, Files BA, McConnell ME, Strandjord SE
    • Waugh WH, Daeschner 3rd CW, Files BA, McConnell ME, Strandjord SE (2001) Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results. J Natl Med Assoc 93: 363-371.
    • (2001) J Natl Med Assoc , vol.93 , pp. 363-371
  • 57
    • 33751161061 scopus 로고    scopus 로고
    • Beneficial effect of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients
    • Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, et al. (2006) Beneficial effect of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 291: E906-E912.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Lucotti, P.1    Setola, E.2    Monti, L.D.3    Galluccio, E.4    Costa, S.5
  • 58
    • 26444617205 scopus 로고    scopus 로고
    • L-citrulline and L-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits
    • Hayashi T, Juliet PAR, Matsui-Hirai H, Miyazaki A, Fukatsu A, et al. (2005) L-citrulline and L-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits. Proc Natl Acad Sci USA 102: 13681-13686.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13681-13686
    • Hayashi, T.1    Juliet, P.A.R.2    Matsui-Hirai, H.3    Miyazaki, A.4    Fukatsu, A.5


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