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Volumn 1812, Issue 11, 2011, Pages 1460-1471

Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: Involvement of advanced glycosylated end products

Author keywords

Cardioprotection; Hyperglycemia; Insulin; Mitochondrial oxidative stress; Streptozotocin

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CYTOCHROME C OXIDASE; DNA; GLUCOSE; INSULIN; METHYLGLYOXAL; MITOCHONDRIAL ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STREPTOZOCIN; SUCCINATE DEHYDROGENASE (UBIQUINONE);

EID: 80053460459     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.06.017     Document Type: Article
Times cited : (40)

References (67)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 2
    • 75149180515 scopus 로고    scopus 로고
    • American Diabetes Association Standards of medical care in diabetes - 2010
    • American Diabetes Association Standards of medical care in diabetes - 2010. Diabetes Care 2010, 33(Suppl 1):S11-S61.
    • (2010) Diabetes Care , vol.33 , Issue.SUPPL.1
  • 6
    • 33847231568 scopus 로고    scopus 로고
    • Coronary microvascular dysfunction
    • Camici P.G., Crea F. Coronary microvascular dysfunction. N. Engl. J. Med. 2007, 356:830-840.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 830-840
    • Camici, P.G.1    Crea, F.2
  • 7
    • 0031848378 scopus 로고    scopus 로고
    • Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study
    • Wei M., Gaskill S.P., Haffner S.M., Stern M.P. Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study. Diabetes Care 1998, 21:1167-1172.
    • (1998) Diabetes Care , vol.21 , pp. 1167-1172
    • Wei, M.1    Gaskill, S.P.2    Haffner, S.M.3    Stern, M.P.4
  • 9
    • 59849090453 scopus 로고    scopus 로고
    • Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association
    • Skyler J.S., Bergenstal R., Bonow R.O., Buse J., Deedwania P., Gale E.A., Howard B.V., Kirkman M.S., Kosiborod M., Reaven P., Sherwin R.S. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Circulation 2009, 119:351-357.
    • (2009) Circulation , vol.119 , pp. 351-357
    • Skyler, J.S.1    Bergenstal, R.2    Bonow, R.O.3    Buse, J.4    Deedwania, P.5    Gale, E.A.6    Howard, B.V.7    Kirkman, M.S.8    Kosiborod, M.9    Reaven, P.10    Sherwin, R.S.11
  • 10
    • 0026455145 scopus 로고
    • Glucose tolerance and the risk of cardiovascular disease: the Zutphen Study
    • Feskens E.J., Kromhout D. Glucose tolerance and the risk of cardiovascular disease: the Zutphen Study. J. Clin. Epidemiol. 1992, 45:1327-1334.
    • (1992) J. Clin. Epidemiol. , vol.45 , pp. 1327-1334
    • Feskens, E.J.1    Kromhout, D.2
  • 11
    • 77249094498 scopus 로고    scopus 로고
    • When are type 1 diabetic patients at risk for cardiovascular disease?
    • Orchard T.J., Costacou T. When are type 1 diabetic patients at risk for cardiovascular disease?. Curr. Diab. Rep. 2010, 10:48-54.
    • (2010) Curr. Diab. Rep. , vol.10 , pp. 48-54
    • Orchard, T.J.1    Costacou, T.2
  • 13
    • 0027370108 scopus 로고
    • Control and Complications Trial Research Group, the effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes The Control and Complications Trial Research Group, the effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 1993, 329:977-986.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
    • Diabetes, T.1
  • 14
    • 0027275397 scopus 로고
    • The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus
    • Reichard P., Nilsson B.Y., Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N. Engl. J. Med. 1993, 329:304-309.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 304-309
    • Reichard, P.1    Nilsson, B.Y.2    Rosenqvist, U.3
  • 15
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: a unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005, 54:1615-1625.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 16
    • 0033571012 scopus 로고    scopus 로고
    • Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    • Thornalley P.J., Langborg A., Minhas H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 1999, 344(Pt 1):109-116.
    • (1999) Biochem. J. , vol.344 , Issue.PART 1 , pp. 109-116
    • Thornalley, P.J.1    Langborg, A.2    Minhas, H.S.3
  • 17
    • 0029118168 scopus 로고
    • Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes
    • Beisswenger P.J., Makita Z., Curphey T.J., Moore L.L., Jean S., Brinck-Johnsen T., Bucala R., Vlassara H. Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes. Diabetes 1995, 44:824-829.
    • (1995) Diabetes , vol.44 , pp. 824-829
    • Beisswenger, P.J.1    Makita, Z.2    Curphey, T.J.3    Moore, L.L.4    Jean, S.5    Brinck-Johnsen, T.6    Bucala, R.7    Vlassara, H.8
  • 20
    • 0028793924 scopus 로고
    • Advanced glycosylation end products in diabetic renal and vascular disease
    • Bucala R., Vlassara H. Advanced glycosylation end products in diabetic renal and vascular disease. Am. J. Kidney Dis. 1995, 26:875-888.
    • (1995) Am. J. Kidney Dis. , vol.26 , pp. 875-888
    • Bucala, R.1    Vlassara, H.2
  • 21
    • 4043058031 scopus 로고    scopus 로고
    • Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
    • Basta G., Schmidt A.M., De Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc. Res. 2004, 63:582-592.
    • (2004) Cardiovasc. Res. , vol.63 , pp. 582-592
    • Basta, G.1    Schmidt, A.M.2    De Caterina, R.3
  • 22
    • 10644282357 scopus 로고    scopus 로고
    • Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease
    • Cooper M.E. Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease. Am. J. Hypertens. 2004, 17:31S-38S.
    • (2004) Am. J. Hypertens. , vol.17
    • Cooper, M.E.1
  • 23
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K.F., Dufour S., Befroy D., Garcia R., Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 2004, 350:664-671.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 27
    • 0037098871 scopus 로고    scopus 로고
    • Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction
    • Denis U., Lecomte M., Paget C., Ruggiero D., Wiernsperger N., Lagarde M. Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction. Free Radic. Biol. Med. 2002, 33:236-247.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 236-247
    • Denis, U.1    Lecomte, M.2    Paget, C.3    Ruggiero, D.4    Wiernsperger, N.5    Lagarde, M.6
  • 28
    • 0036306098 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
    • Romeo G., Liu W.H., Asnaghi V., Kern T.S., Lorenzi M. Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes 2002, 51:2241-2248.
    • (2002) Diabetes , vol.51 , pp. 2241-2248
    • Romeo, G.1    Liu, W.H.2    Asnaghi, V.3    Kern, T.S.4    Lorenzi, M.5
  • 29
    • 79955595448 scopus 로고    scopus 로고
    • Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy
    • Kim J., Kim C.S., Sohn E., Jeong I.H., Kim H., Kim J.S. Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy. Graefes Arch. Clin. Exp. Ophthalmol. 2011, 249:529-536.
    • (2011) Graefes Arch. Clin. Exp. Ophthalmol. , vol.249 , pp. 529-536
    • Kim, J.1    Kim, C.S.2    Sohn, E.3    Jeong, I.H.4    Kim, H.5    Kim, J.S.6
  • 32
    • 0028597991 scopus 로고
    • Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor
    • Westwood M.E., McLellan A.C., Thornalley P.J. Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptor. J. Biol. Chem. 1994, 269:32293-32298.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32293-32298
    • Westwood, M.E.1    McLellan, A.C.2    Thornalley, P.J.3
  • 33
    • 0013889689 scopus 로고
    • Determination of free amino groups in proteins by trinitrobenzenesulfonic acid
    • Habeeb A.F. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal. Biochem. 1966, 14:328-336.
    • (1966) Anal. Biochem. , vol.14 , pp. 328-336
    • Habeeb, A.F.1
  • 34
    • 0035968307 scopus 로고    scopus 로고
    • Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor
    • Biemel K.M., Reihl O., Conrad J., Lederer M.O. Formation pathways for lysine-arginine cross-links derived from hexoses and pentoses by Maillard processes: unraveling the structure of a pentosidine precursor. J. Biol. Chem. 2001, 276:23405-23412.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23405-23412
    • Biemel, K.M.1    Reihl, O.2    Conrad, J.3    Lederer, M.O.4
  • 35
    • 0028239163 scopus 로고
    • Oxidative damage to proteins: spectrophotometric method for carbonyl assay
    • Reznick A.Z., Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 1994, 233:357-363.
    • (1994) Methods Enzymol. , vol.233 , pp. 357-363
    • Reznick, A.Z.1    Packer, L.2
  • 37
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 38
    • 0029998238 scopus 로고    scopus 로고
    • Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport
    • Cassina A., Radi R. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch. Biochem. Biophys. 1996, 328:309-316.
    • (1996) Arch. Biochem. Biophys. , vol.328 , pp. 309-316
    • Cassina, A.1    Radi, R.2
  • 42
    • 3042781117 scopus 로고    scopus 로고
    • Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
    • Hutter E., Renner K., Pfister G., Stockl P., Jansen-Durr P., Gnaiger E. Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem. J. 2004, 380:919-928.
    • (2004) Biochem. J. , vol.380 , pp. 919-928
    • Hutter, E.1    Renner, K.2    Pfister, G.3    Stockl, P.4    Jansen-Durr, P.5    Gnaiger, E.6
  • 43
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • Rosen P., Nawroth P.P., King G., Moller W., Tritschler H.J., Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab. Res. Rev. 2001, 17:189-212.
    • (2001) Diabetes Metab. Res. Rev. , vol.17 , pp. 189-212
    • Rosen, P.1    Nawroth, P.P.2    King, G.3    Moller, W.4    Tritschler, H.J.5    Packer, L.6
  • 44
    • 0033994409 scopus 로고    scopus 로고
    • Radicals and oxidative stress in diabetes
    • West I.C. Radicals and oxidative stress in diabetes. Diabet. Med. 2000, 17:171-180.
    • (2000) Diabet. Med. , vol.17 , pp. 171-180
    • West, I.C.1
  • 46
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du X.L., Edelstein D., Rossetti L., Fantus I.G., Goldberg H., Ziyadeh F., Wu J., Brownlee M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:12222-12226.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3    Fantus, I.G.4    Goldberg, H.5    Ziyadeh, F.6    Wu, J.7    Brownlee, M.8
  • 47
    • 0017154414 scopus 로고
    • Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
    • Boveris A., Cadenas E., Stoppani A.O. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 1976, 156:435-444.
    • (1976) Biochem. J. , vol.156 , pp. 435-444
    • Boveris, A.1    Cadenas, E.2    Stoppani, A.O.3
  • 48
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: central role of complex III
    • Chen Q., Vazquez E.J., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 2003, 278:36027-36031.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 49
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens J.F. Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 1997, 17:3-8.
    • (1997) Biosci. Rep. , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 50
    • 0019083215 scopus 로고
    • Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
    • Turrens J.F., Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 1980, 191:421-427.
    • (1980) Biochem. J. , vol.191 , pp. 421-427
    • Turrens, J.F.1    Boveris, A.2
  • 51
    • 0035162338 scopus 로고    scopus 로고
    • Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease
    • Chinopoulos C., Adam-Vizi V. Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J. Neurochem. 2001, 76:302-306.
    • (2001) J. Neurochem. , vol.76 , pp. 302-306
    • Chinopoulos, C.1    Adam-Vizi, V.2
  • 52
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • El-Osta A., Brasacchio D., Yao D., Pocai A., Jones P.L., Roeder R.G., Cooper M.E., Brownlee M. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med. 2008, 205:2409-2417.
    • (2008) J. Exp. Med. , vol.205 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3    Pocai, A.4    Jones, P.L.5    Roeder, R.G.6    Cooper, M.E.7    Brownlee, M.8
  • 54
    • 0037029049 scopus 로고    scopus 로고
    • Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells
    • Scarpulla R.C. Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells. Gene 2002, 286:81-89.
    • (2002) Gene , vol.286 , pp. 81-89
    • Scarpulla, R.C.1
  • 55
    • 0141634243 scopus 로고    scopus 로고
    • Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles
    • Garnier A., Fortin D., Delomenie C., Momken I., Veksler V., Ventura-Clapier R. Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J. Physiol. 2003, 551:491-501.
    • (2003) J. Physiol. , vol.551 , pp. 491-501
    • Garnier, A.1    Fortin, D.2    Delomenie, C.3    Momken, I.4    Veksler, V.5    Ventura-Clapier, R.6
  • 56
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
    • Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 2003, 24:78-90.
    • (2003) Endocr. Rev. , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 57
    • 70450273227 scopus 로고    scopus 로고
    • "Blinding" of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?
    • Gugliucci A. "Blinding" of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?. Med. Hypotheses 2009, 73:921-924.
    • (2009) Med. Hypotheses , vol.73 , pp. 921-924
    • Gugliucci, A.1
  • 59
    • 77953582293 scopus 로고    scopus 로고
    • The antioxidant effect of antiotensin II receptor blocker, losartan, in streptozotocin-induced diabetic rats
    • Kamper M., Tsimpoukidi O., Chatzigeorgiou A., Lymberi M., Kamper E.F. The antioxidant effect of antiotensin II receptor blocker, losartan, in streptozotocin-induced diabetic rats. Transl. Res. 2010, 156:26-36.
    • (2010) Transl. Res. , vol.156 , pp. 26-36
    • Kamper, M.1    Tsimpoukidi, O.2    Chatzigeorgiou, A.3    Lymberi, M.4    Kamper, E.F.5
  • 60
    • 79955479655 scopus 로고    scopus 로고
    • PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function
    • Lupachyk S., Shevalye H., Maksimchyk Y., Drel V.R., Obrosova I.G. PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: correlation with peripheral nerve function. Free Radic. Biol. Med. 2011, 50:1400-1409.
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 1400-1409
    • Lupachyk, S.1    Shevalye, H.2    Maksimchyk, Y.3    Drel, V.R.4    Obrosova, I.G.5
  • 61
    • 24344436796 scopus 로고    scopus 로고
    • Glycation, ageing and carnosine: are carnivorous diets beneficial?
    • Hipkiss A.R. Glycation, ageing and carnosine: are carnivorous diets beneficial?. Mech. Ageing Dev. 2005, 126:1034-1039.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 1034-1039
    • Hipkiss, A.R.1
  • 62
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: apoptosis regulation by the PI3K/PKB pathway
    • Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem. J. 2008, 415:333-344.
    • (2008) Biochem. J. , vol.415 , pp. 333-344
    • Duronio, V.1
  • 64
    • 0034044814 scopus 로고    scopus 로고
    • The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications
    • Haluzik M., Nedvidkova J. The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications. Physiol. Res. 2000, 49(Suppl 1):S37-S42.
    • (2000) Physiol. Res. , vol.49 , Issue.SUPPL.1
    • Haluzik, M.1    Nedvidkova, J.2
  • 66
    • 33748802532 scopus 로고    scopus 로고
    • Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
    • Cai W., He J.C., Zhu L., Lu C., Vlassara H. Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:13801-13806.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 13801-13806
    • Cai, W.1    He, J.C.2    Zhu, L.3    Lu, C.4    Vlassara, H.5


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