Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: Role of complex i inhibition vs. depolarization of inner mitochondrial membrane

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 10, 2013, Pages 4537-4542

  Ross, Thomas ^a   Szczepanek, Karol ^a   Bowler, Elizabeth ^a,c   Hu, Ying ^a   Larner, Andrew ^b   Lesnefsky, Edward J ^a,b,d   Chen, Qun ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Electron transport chain; Ischemia; Reactive oxygen species; STAT3

Indexed keywords

2,4 DINITROPHENOL; AMPLEX RED; ANTIMYCIN A1; FLUORESCENT DYE; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; STAT3 PROTEIN; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE ELECTRON FLOW INDUCED REACTIVE OXYGEN SPECIES GENERATION; TRANSGENIC MOUSE;

ELECTRON TRANSPORT CHAIN; ISCHEMIA; REACTIVE OXYGEN SPECIES; STAT3;

ANIMALS; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; REACTIVE OXYGEN SPECIES;

ARMORACIA RUSTICANA;

EID: 84879495907     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.05.035     Document Type: Article

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