A unique strain of community-acquired Clostridium difficile in severe complicated infection and death of a young adult

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Heslop, Orville D ^a   Roye Green, Karen ^a   Coard, Kathleen ^a   Mulvey, Michael R ^b  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

Clindamycin; Clostridium difficile; Community Acquired Infection; Diarrhoea; Klebsiella pneumoniae; Pseudomembranous Colitis; Toxic Megacolon

Indexed keywords

CEFTRIAXONE; CLINDAMYCIN; GENTAMICIN; METRONIDAZOLE;

ADULT; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATION; BLOOD CULTURE; CASE REPORT; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; COMMUNICABLE DISEASE; DEATH; DIARRHEA; DISEASE DURATION; DISEASE EXACERBATION; DISEASE SEVERITY; FECES ANALYSIS; FEMALE; GRAM NEGATIVE SEPSIS; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; INTESTINE PERFORATION; JAMAICA; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LENGTH OF STAY; NONHUMAN; PHYSICAL EXAMINATION; PSEUDOMEMBRANOUS COLITIS; TOOTH ABSCESS; TOOTH EXTRACTION; TOXIC MEGACOLON; UNIVERSITY HOSPITAL; UNIVERSITY STUDENT;

ADULT; CLINDAMYCIN; CLOSTRIDIUM DIFFICILE; COMMUNITY-ACQUIRED INFECTIONS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FATAL OUTCOME; FEMALE; HOSPITALIZATION; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MEGACOLON, TOXIC; YOUNG ADULT;

EID: 84879495249     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-299     Document Type: Article

References (12)

1. Apisarnthanarak A, Khoury H, Reinus WR, Crippin JS, Mundy LM. Severe Clostridium difficile colitis: the role of intracolonic vancomycin?. Am J Med 2002, 112:329-329. 10.1016/S0002-9343(01)01102-0, 11893380.
2. Aslam S, Musher D. An update diagnosis, treatment, and prevention of Clostridium difficile associated disease. Gastroenterol Clin Am 2006, 35:315-335.
3. Khanna S, Pardi DS, Aronson SL, Kammer PP, Orenstein R, St Sauver JL, Harmsen WS, Zinsmeister AR. The epidemiology of community acquired Clostridium difficile infection: A population based study. Am J Gastroenterol 2012, 107(1):89-95. http://www.endonurse.com/, 10.1038/ajg.2011.398, 3273904, 22108454.
4. Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 1978, 298:531-534. 10.1056/NEJM197803092981003, 625309.
5. Owens RC, Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial Associated Risk Factors for Clostridium difficile Infection. Clin Infect Dis 2008, 46(Suppl 1):S19.
6. Mulvey MR, Boyd DA, Gravel D, Hutchinson J, Kelly S, Mcgeer A, Moore D, Simor A, Suh KN, Taylor G, Weese S, Miller M. Hyper-virulent Clostridium difficile strains in hospitalised patients, Canada. Emerg Infect Dis 2010, 16(4):678-681. 10.3201/eid1604.091152, 3321949, 20350386.
7. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455. 10.1086/651706, 20307191.
8. Khanna S, Pardi DS, Aronson SL, Kammer PP, Baddour LM. Outcomes in community-acquired Clostridium difficile infection. Aliment Pharmacol Ther 2012, 35(5):613-618. 10.1111/j.1365-2036.2011.04984.x, 3293482, 22229532.
9. Koss K, Clark MA, Sanders DS, Morton D, Keighley MB, Goh J. The outcome of surgery in fulminant Clostridium difficile colitis. Colorectal Dis 2006, 8(2):149-154. 10.1111/j.1463-1318.2005.00876.x, 16412077.
10. Murray R, Boyd D, Levett PN, Mulvey MR, Alfa MJ. Truncation in the tcdC region of the Clostridium difficile PatLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A. BMC Infect Dis 2009, 9:103. 10.1186/1471-2334-9-103, 2707377, 19558711.
11. Urbán E, Brazier JS, Sóki J, Nagy E, Duerden BI. PCR ribotyping of clinically important Clostridium difficile strains from Hungary. J Med Microbiol 2001, 50:1082-1086.
12. Sayedy L, Kothari D, Richards RJ. Toxicmegacolon associated Clostridium difficile colitis. World J Gastrointest Endosc 2010, 2(8):293-297. 10.4253/wjge.v2.i8.293, 2999149, 21160629.