Intensity-modulated radiotherapy with simultaneous modulated accelerated boost technique and chemotherapy in patients with nasopharyngeal carcinoma

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Fareed, Muhammad M ^a   AlAmro, Abdullah S ^a   Bayoumi, Yasser ^b   Tunio, Mutahir A ^a   Ismail, Abdul S ^c   Akasha, Rashad ^a   Mubasher, Mohamed ^a   Al Asiri, Mushabbab ^a  

^a KING FAHAD MEDICAL CITY   (Saudi Arabia)

^b CAIRO UNIVERSITY   (Egypt)

^c ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Intensity modulated Radiotherapy (IMRT); Nasopharyngeal Carcinoma; Simultaneous Modulated Accelerated Radiotherapy (SMART) Boost Technique

Indexed keywords

CISPLATIN; DOCETAXEL; EPIRUBICIN; FLUOROURACIL; ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGED; AGEUSIA; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG SAFETY; EPSTEIN BARR VIRUS INFECTION; FEMALE; HEARING IMPAIRMENT; HUMAN; INFLAMMATION; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; OUTCOME ASSESSMENT; RADIATION DOSE; RADIATION RESPONSE; SALIVARY GLAND DISEASE; SIMULTANEOUS MODULATED ACCELERATED RADIOTHERAPY BOOST TECHNIQUE; SKIN MANIFESTATION; SURVIVAL TIME; TREATMENT FAILURE; XEROSTOMIA; CHEMORADIOTHERAPY; KAPLAN MEIER METHOD; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROCEDURES; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84879491194     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-318     Document Type: Article

References (16)

1. Lee N, Harris J, Garden AS, et al. Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009, 27:3684-90. 10.1200/JCO.2008.19.9109, 2720082, 19564532.
2. Chung JB, Lee JW, Kim JS, et al. Comparison of target coverage and dose to organs at risk between simultaneous integrated-boost whole-field intensity-modulated radiation therapy and junctioned intensity-modulated radiation therapy with a conventional radiotherapy field in treatment of nasopharyngeal carcinoma. Radiol Phys Technol 2011, 4:180-4. 10.1007/s12194-011-0119-0, 21556851.
3. Xia P, Fu KK, Wong GW, et al. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000, 48:329-37.
4. Kam MK, Chau RM, Suen J, et al. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: Dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys 2003, 56:145-57. 10.1016/S0360-3016(03)00075-0, 12694833.
5. Perri F, Bosso D, Buonerba C, et al. Locally advanced nasopharyngeal carcinoma: Current and emerging treatment strategies. World J Clin Oncol 2011, 2:377-83. 10.5306/wjco.v2.i12.377, 3235656, 22171280.
6. Lin S, Lu JJ, Han L, et al. Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: experience of 370 consecutive cases. BMC Cancer 2010, 10:39. 10.1186/1471-2407-10-39, 2836300, 20146823.
7. Al-Amro A, Al-Rajhi N, Khafaga Y, et al. Neoadjuvant chemotherapy followed by concurrent chemo-radiation therapy in locally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2005, 62:508-13. 10.1016/j.ijrobp.2004.09.050, 15890594.
8. Xiao WW, Huang SM, Han F, et al. Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study. Cancer 2011, 117:1874-83. 10.1002/cncr.25754, 21509764.
9. Han L, Lin SJ, Pan JJ, et al. Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. Chin J Cancer 2010, 29:145-50. 10.5732/cjc.009.10332, 20109341.
10. Kim K, Wu HG, Kim HJ, et al. Intensity-modulated radiation therapy with simultaneous integrated boost technique following neoadjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma. Head Neck 2009, 31:1121-8. 10.1002/hed.21076, 19340863.
11. Tham IW, Hee SW, Yeo RM, et al. Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer center Singapore experience. Int J Radiat Oncol Biol Phys 2009, 75:1481-6. 10.1016/j.ijrobp.2009.01.018, 19386431.
12. Ng WT, Lee MC, Hung WM, et al. Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2011, 79:420-8. 10.1016/j.ijrobp.2009.11.024, 20452132.
13. Lee AW, Lin JC, Ng WT, et al. Current Management of Nasopharyngeal Cancer. Semin Radiat Oncol 2012, 22:233-44. 10.1016/j.semradonc.2012.03.008, 22687948.
14. Lu H, Peng L, Yuan X, et al. Concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a treatment paradigm also applicable to patients in Southeast Asia. Cancer Treat Rev 2009, 35:345-53. 10.1016/j.ctrv.2009.01.002, 19211192.
15. Kong L, Zhang YW, Hu CS, et al. Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma. Chin J Cancer 2010, 29:551-55. 10.5732/cjc.009.10518, 20426907.
16. Palazzi M, Orlandi E, Bossi P, et al. Further improvement in outcomes of nasopharyngeal carcinoma with optimized radiotherapy and induction plus concomitant chemotherapy: an update of the Milan experience. Int J Radiat Oncol Biol Phys 2009, 74:774-780. 10.1016/j.ijrobp.2008.08.068, 19250771.