Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma

Chinese Journal of Cancer

Volumn 29, Issue 5, 2010, Pages 551-555

  Kong, Lin ^a   Zhang, You Wang ^a   Hu, Chao Su ^a   Guo, Ye ^a  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Chemotherapy; Concurrent neoadjuvant; Nasopharyngeal neoplasm; Radiotherapy

Indexed keywords

CISPLATIN; DOCETAXEL; FLUOROURACIL;

ADULT; AGED; ANEMIA; ANOREXIA; ARTICLE; BONE MARROW SUPPRESSION; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; COMPUTER ASSISTED RADIOTHERAPY; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; HUMAN; INTENSITY MODULATED RADIATION THERAPY; KIDNEY DYSFUNCTION; LEUKOPENIA; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; NAUSEA; NEUTROPENIA; OUTCOME ASSESSMENT; RADIATION DERMATITIS; SKIN EXFOLIATION; SKIN MANIFESTATION; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING; XEROSTOMIA;

EID: 78951486556     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.009.10518     Document Type: Article

References (23)

1. Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099 [J]. J Clin Oncol, 1998, 16(4): 1310-1317.
2. Lin JC, Jan JS, Hsu CY, et al. Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival [J]. J Clin Oncol, 2003, 21(4): 631-637.
3. Chan AT, Leung SF, Ngan RK, et al. Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma [J]. J Natl Cancer Inst, 2005, 97(7): 536-539.
4. Zhang L, Zhao C, Peng PJ, et al. Phase III study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma: preliminary results [J]. J Clin Oncol, 2005, 23(33): 8461-8468.
5. Lee AW, Lau WH, Tung SY, et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group [J]. J Clin Oncol, 2005, 23(28): 6966-6975.
6. Wee J, Tan EH, Tai BC, Wong HB, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/ International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety [J]. J Clin Oncol, 2005, 23(27): 6730-6738.
7. Hitt R, Lopez-Pousa A, Martinez-Trufero J, et al. Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer [J]. J Clin Oncol, 2005, 23(34): 8636-8645.
8. Vermorken JB, Remenar E, van Herpen C, et al. EORTC 24971/TAX 323 Study Group. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer [J]. N Engl J Med, 2007, 357(17): 1695-1704.
9. Posner MR, Hershock DM, Blajman CR, et al. TAX 324 Study Group. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer [J]. N Engl J Med, 2007, 357(17): 1705-1715.
10. Heng DMK, Wee J, Fong KW, et al. Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma [J]. Cancer, 1999, 86(10): 1912-1920.
11. Hong MH, Mai HQ, Min HQ, et al. A comparison of the Chinese 1992 and fifth edition International Union against Cancer Staging Systems for staging nasopharyngeal carcinoma [J]. Cancer, 2000, 89(2): 242-247.
12. Ma J, Mai HQ, Hong MH, et al. Is the 1997 AJCC staging system for nasopharyngeal carcinoma prognostically useful for Chinese patient population? [J]. Int J Radiat Oncol Biol Phys, 2001, 50(5): 1181-1189.
13. International Nasopharynx Cancer Study Group. Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV(> or = N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progression-free survival. VUMCA I trial [J]. Int J Radiat Oncol Biol Phys, 1996, 35(3): 463-469.
14. Chua DT, Sham JS, Choy D, et al. Preliminary report of the asian-oceanian clinical oncology association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma [J]. Cancer, 1998, 83(11): 2255-2258.
15. Ma J, Mai HQ, Hong MH, et al. Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma [J]. J Clin Oncol, 2001, 19(5): 1350-1357.
16. Langendijk JA, Leemans CR, Buter J, et al. The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature [J]. J Clin Oncol, 2004, 22(22): 4604-4612.
17. Chua DT, Ma J, Sham JS, et al. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials [J]. J Clin Oncol, 2005, 23(6): 1118-1124.
18. Rischin D, Corry J, Smith J, et al. Excellent disease control and survival in patients with advanced nasopharyngeal cancer treated with chemoradiation [J]. J Clin Oncol, 2002, 20(7): 1845-1852.
19. Johnson FM, Garden A, Palmer JL, et al. A Phase II study of docetaxel and carboplatin as neoadjuvant therapy for nasopharyngeal carcinoma with early T status and advanced N status [J]. Cancer, 2004, 100(5): 991-998.
20. Chan AT, Ma BB, Lo YM, et al. Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: therapeutic monitoring with plasma Epstein-Barr virus DNA [J]. J Clin Oncol, 2004, 22(15): 3053-3060.
21. Al-Amro A, Al-Rajhi N, Khafaga Y, et al. Neoadjuvant chemotherapy followed by concurrent chemo-radiation therapy in locally advanced nasopharyngeal carcinoma [J]. Int J Radiat Oncol Biol Phys, 2005, 62(2): 508-5013.
22. Johnson FM, Garden AS, Palmer JL, et al. A phase I/II study of neoadjuvant chemotherapy followed by radiation with boost chemotherapy for advanced T-stage nasopharyngeal carcinoma [J]. Int J Radiat Oncol Biol Phys, 2005, 63(3): 717-724.
23. Hui EP, Ma BB, Leung SF, et al. Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma [J]. J Clin Oncol, 2009, 27(2): 242-249.