메뉴 건너뛰기




Volumn 8, Issue 6, 2013, Pages

In Intact Islets Interstitial GABA Activates GABAA Receptors That Generate Tonic Currents in α-Cells

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA4; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA6; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA1; 4 AMINOBUTYRIC ACID A RECEPTOR RHO1; 4 AMINOBUTYRIC ACID A RECEPTOR RHO2; 4 AMINOBUTYRIC ACID A RECEPTOR RHO3; MESSENGER RNA; PENTOBARBITAL; UNCLASSIFIED DRUG;

EID: 84879487313     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067228     Document Type: Article
Times cited : (19)

References (40)
  • 1
    • 84868196557 scopus 로고    scopus 로고
    • Paracrine interactions within islets of langerhans
    • Koh DS, Cho JH, Chen L, (2012) Paracrine interactions within islets of langerhans. J Mol Neurosci 48: 429-440.
    • (2012) J Mol Neurosci , vol.48 , pp. 429-440
    • Koh, D.S.1    Cho, J.H.2    Chen, L.3
  • 2
  • 3
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains
    • Gromada J, Franklin I, Wollheim CB, (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28: 84-116.
    • (2007) Endocr Rev , vol.28 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 5
    • 0018757849 scopus 로고
    • High concentration of gamma-aminobutyric acid in pancreatic beta cells
    • Taniguchi H, Okada Y, Seguchi H, Shimada C, Seki M, et al. (1979) High concentration of gamma-aminobutyric acid in pancreatic beta cells. Diabetes 28: 629-633.
    • (1979) Diabetes , vol.28 , pp. 629-633
    • Taniguchi, H.1    Okada, Y.2    Seguchi, H.3    Shimada, C.4    Seki, M.5
  • 6
    • 0024470349 scopus 로고
    • Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels
    • Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, et al. (1989) Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 341: 233-236.
    • (1989) Nature , vol.341 , pp. 233-236
    • Rorsman, P.1    Berggren, P.O.2    Bokvist, K.3    Ericson, H.4    Möhler, H.5
  • 7
    • 0025875235 scopus 로고
    • GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion
    • Reetz A, Solimena M, Matteoli M, Folli F, Takei K, et al. (1991) GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J 10: 1275-1284.
    • (1991) EMBO J , vol.10 , pp. 1275-1284
    • Reetz, A.1    Solimena, M.2    Matteoli, M.3    Folli, F.4    Takei, K.5
  • 8
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
    • Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, et al. (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156.
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.J.2    Christgau, S.3    Reetz, A.4    Solimena, M.5
  • 9
    • 0026690837 scopus 로고
    • Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
    • Christgau S, Aanstoot HJ, Schierbeck H, Begley K, Tullin S, et al. (1992) Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. J Cell Biol 118: 309-320.
    • (1992) J Cell Biol , vol.118 , pp. 309-320
    • Christgau, S.1    Aanstoot, H.J.2    Schierbeck, H.3    Begley, K.4    Tullin, S.5
  • 10
    • 0036231547 scopus 로고    scopus 로고
    • GABA in the endocrine pancreas: cellular localization and function in normal and diabetic rats
    • Adeghate E, Ponery AS, (2002) GABA in the endocrine pancreas: cellular localization and function in normal and diabetic rats. Tissue Cell 34: 1-6.
    • (2002) Tissue Cell , vol.34 , pp. 1-6
    • Adeghate, E.1    Ponery, A.S.2
  • 11
    • 1442358665 scopus 로고    scopus 로고
    • Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells
    • Braun M, Wendt A, Birnir B, Broman J, Eliasson L, et al. (2004) Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. J Gen Physiol 123: 191-204.
    • (2004) J Gen Physiol , vol.123 , pp. 191-204
    • Braun, M.1    Wendt, A.2    Birnir, B.3    Broman, J.4    Eliasson, L.5
  • 12
    • 77954252193 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells
    • Braun M, Ramracheya R, Bengtsson M, Clark A, Walker JN, et al. (2010) Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes 59: 1694-1701.
    • (2010) Diabetes , vol.59 , pp. 1694-1701
    • Braun, M.1    Ramracheya, R.2    Bengtsson, M.3    Clark, A.4    Walker, J.N.5
  • 13
    • 0031438061 scopus 로고    scopus 로고
    • Nutrient regulation of gamma-aminobutyric acid release from islet beta cells
    • Smismans A, Schuit F, Pipeleers D, (1997) Nutrient regulation of gamma-aminobutyric acid release from islet beta cells. Diabetologia 40: 1411-1415.
    • (1997) Diabetologia , vol.40 , pp. 1411-1415
    • Smismans, A.1    Schuit, F.2    Pipeleers, D.3
  • 14
    • 0031854439 scopus 로고    scopus 로고
    • Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit?
    • Satin LS, Kinard TA, (1998) Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit? Endocrine 8: 213-223.
    • (1998) Endocrine , vol.8 , pp. 213-223
    • Satin, L.S.1    Kinard, T.A.2
  • 15
    • 0033065979 scopus 로고    scopus 로고
    • Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice
    • Kash SF, Condie BG, Baekkeskov S, (1999) Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice. Horm Metab Res 31: 340-344.
    • (1999) Horm Metab Res , vol.31 , pp. 340-344
    • Kash, S.F.1    Condie, B.G.2    Baekkeskov, S.3
  • 16
    • 0033834685 scopus 로고    scopus 로고
    • Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion
    • Shi Y, Kanaani J, Menard-Rose V, Ma YH, Chang PY, et al. (2000) Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion. Am J Physiol Endocrinol Metab 279: E684-694.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Shi, Y.1    Kanaani, J.2    Menard-Rose, V.3    Ma, Y.H.4    Chang, P.Y.5
  • 17
    • 84866402723 scopus 로고    scopus 로고
    • γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
    • Taneera J, Jin Z, Jin Y, Muhammed SJ, Zhang E, et al. (2012) γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes. Diabetologia 55: 1985-1994.
    • (2012) Diabetologia , vol.55 , pp. 1985-1994
    • Taneera, J.1    Jin, Z.2    Jin, Y.3    Muhammed, S.J.4    Zhang, E.5
  • 18
    • 4644278226 scopus 로고    scopus 로고
    • GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin
    • Braun M, Wendt A, Buschard K, Salehi A, Sewing S, et al. (2004) GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol 559: 397-409.
    • (2004) J Physiol , vol.559 , pp. 397-409
    • Braun, M.1    Wendt, A.2    Buschard, K.3    Salehi, A.4    Sewing, S.5
  • 19
    • 1842422955 scopus 로고    scopus 로고
    • Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells
    • Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, et al. (2004) Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes 53: 1038-1045.
    • (2004) Diabetes , vol.53 , pp. 1038-1045
    • Wendt, A.1    Birnir, B.2    Buschard, K.3    Gromada, J.4    Salehi, A.5
  • 21
    • 58049133111 scopus 로고    scopus 로고
    • GABA A receptors: subtypes provide diversity of function and pharmacology
    • Olsen RW, Sieghart W, (2009) GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology 56: 141-148.
    • (2009) Neuropharmacology , vol.56 , pp. 141-148
    • Olsen, R.W.1    Sieghart, W.2
  • 22
    • 1942501006 scopus 로고    scopus 로고
    • Tonically active GABA A receptors: modulating gain and maintaining the tone
    • Semyanov A, Walker MC, Kullmann DM, Silver RA, (2004) Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci 27: 262-269.
    • (2004) Trends Neurosci , vol.27 , pp. 262-269
    • Semyanov, A.1    Walker, M.C.2    Kullmann, D.M.3    Silver, R.A.4
  • 23
    • 34047237937 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase
    • Wang C, Mao R, Van de Casteele M, Pipeleers D, Ling Z, (2007) Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase. Am J Physiol Endocrinol Metab 292: E1201-1206.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Wang, C.1    Mao, R.2    Van de Casteele, M.3    Pipeleers, D.4    Ling, Z.5
  • 24
    • 0023203183 scopus 로고
    • Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
    • Sandler S, Andersson A, Hellerström C, (1987) Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 121: 1424-1431.
    • (1987) Endocrinology , vol.121 , pp. 1424-1431
    • Sandler, S.1    Andersson, A.2    Hellerström, C.3
  • 25
    • 0343986289 scopus 로고    scopus 로고
    • Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets
    • Göpel S, Kanno T, Barg S, Galvanovskis J, Rorsman P, (1999) Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets. J Physiol 521 Pt 3: 717-728.
    • (1999) J Physiol 521 Pt , vol.3 , pp. 717-728
    • Göpel, S.1    Kanno, T.2    Barg, S.3    Galvanovskis, J.4    Rorsman, P.5
  • 26
    • 34547097254 scopus 로고    scopus 로고
    • The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus
    • Glykys J, Mody I, (2007) The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol 582: 1163-1178.
    • (2007) J Physiol , vol.582 , pp. 1163-1178
    • Glykys, J.1    Mody, I.2
  • 28
    • 79960696818 scopus 로고    scopus 로고
    • Java web tools for PCR, in silico PCR, and oligonucleotide assembly and analysis
    • Kalendar R, Lee D, Schulman AH, (2011) Java web tools for PCR, in silico PCR, and oligonucleotide assembly and analysis. Genomics 98: 137-144.
    • (2011) Genomics , vol.98 , pp. 137-144
    • Kalendar, R.1    Lee, D.2    Schulman, A.H.3
  • 29
    • 78650599930 scopus 로고    scopus 로고
    • Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates
    • Mendu SK, Akesson L, Jin Z, Edlund A, Cilio C, et al. (2011) Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates. Mol Immunol 48: 399-407.
    • (2011) Mol Immunol , vol.48 , pp. 399-407
    • Mendu, S.K.1    Akesson, L.2    Jin, Z.3    Edlund, A.4    Cilio, C.5
  • 30
    • 33144467088 scopus 로고    scopus 로고
    • The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
    • Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, et al. (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 103: 2334-2339.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2334-2339
    • Cabrera, O.1    Berman, D.M.2    Kenyon, N.S.3    Ricordi, C.4    Berggren, P.O.5
  • 32
    • 0033850226 scopus 로고    scopus 로고
    • Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells
    • Barg S, Galvanovskis J, Göpel SO, Rorsman P, Eliasson L, (2000) Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 49: 1500-1510.
    • (2000) Diabetes , vol.49 , pp. 1500-1510
    • Barg, S.1    Galvanovskis, J.2    Göpel, S.O.3    Rorsman, P.4    Eliasson, L.5
  • 33
    • 26844491714 scopus 로고    scopus 로고
    • Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse
    • Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, et al. (2005) Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology 146: 4766-4775.
    • (2005) Endocrinology , vol.146 , pp. 4766-4775
    • Leung, Y.M.1    Ahmed, I.2    Sheu, L.3    Tsushima, R.G.4    Diamant, N.E.5
  • 34
    • 33645051453 scopus 로고    scopus 로고
    • Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system
    • Xu E, Kumar M, Zhang Y, Ju W, Obata T, et al. (2006) Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab 3: 47-58.
    • (2006) Cell Metab , vol.3 , pp. 47-58
    • Xu, E.1    Kumar, M.2    Zhang, Y.3    Ju, W.4    Obata, T.5
  • 35
    • 33646556407 scopus 로고    scopus 로고
    • Graded response to GABA by native extrasynaptic GABA receptors
    • Lindquist CE, Birnir B, (2006) Graded response to GABA by native extrasynaptic GABA receptors. J Neurochem 97: 1349-1356.
    • (2006) J Neurochem , vol.97 , pp. 1349-1356
    • Lindquist, C.E.1    Birnir, B.2
  • 36
    • 79251552543 scopus 로고    scopus 로고
    • Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
    • Jin Z, Jin Y, Kumar-Mendu S, Degerman E, Groop L, et al. (2011) Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current. PLoS One 6: e16188.
    • (2011) PLoS One , vol.6
    • Jin, Z.1    Jin, Y.2    Kumar-Mendu, S.3    Degerman, E.4    Groop, L.5
  • 37
  • 38
    • 0023162271 scopus 로고
    • Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones
    • Bormann J, Hamill OP, Sakmann B, (1987) Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J Physiol 385: 243-286.
    • (1987) J Physiol , vol.385 , pp. 243-286
    • Bormann, J.1    Hamill, O.P.2    Sakmann, B.3
  • 39
    • 0024474066 scopus 로고
    • Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture
    • Macdonald RL, Rogers CJ, Twyman RE, (1989) Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J Physiol 410: 479-499.
    • (1989) J Physiol , vol.410 , pp. 479-499
    • Macdonald, R.L.1    Rogers, C.J.2    Twyman, R.E.3
  • 40
    • 0028173169 scopus 로고
    • Characteristics of GABAA channels in rat dentate gyrus
    • Birnir B, Everitt AB, Gage PW, (1994) Characteristics of GABAA channels in rat dentate gyrus. J Membr Biol 142: 93-102.
    • (1994) J Membr Biol , vol.142 , pp. 93-102
    • Birnir, B.1    Everitt, A.B.2    Gage, P.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.