The GSTP1 105Val Allele Increases Breast Cancer Risk and Aggressiveness but Enhances Response to Cyclophosphamide Chemotherapy in North China

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Ge, Jie ^a,b   Tian, Ai Xian ^a   Wang, Qing Shan ^a,b   Kong, Peng Zhou ^a   Yu, Yue ^a   Li, Xiao Qing ^a,b   Cao, Xu Chen ^a,b   Feng, Yu Mei ^a,b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; GLUTATHIONE TRANSFERASE P1; VALINE;

ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CHEMOSENSITIVITY; CHINA; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GLUTATHIONE TRANSFERASE P1 GENE; HUMAN; IN VITRO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MITOSIS INHIBITION;

ADULT; AGED; ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CHINA; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; YOUNG ADULT;

EID: 84879478776     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067589     Document Type: Article

References (35)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249. doi:10.3322/caac.20006. PubMed: 19474385.
2. Collaborative Group on Hormonal Factors in Breast Cancer (2002) Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet 360: 187-195. doi:10.1016/S0140-6736(02)09454-0. PubMed: 12133652.
3. Eichelbaum M, Ingelman-Sundberg M, Evans WE, (2006) Pharmacogenomics and individualized drug therapy. Annu Rev Med 57: 119-137. doi:10.1146/annurev.med.56.082103.104724. PubMed: 16409140.
4. Ragaz J, Olivotto IA, Spinelli JJ, Phillips N, Jackson SM, et al. (2005) Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 97: 116-126. doi:10.1093/jnci/djh297. PubMed: 15657341.
5. Chia S, Swain SM, Byrd DR, Mankoff DA, (2008) Locally advanced and inflammatory breast cancer. J Clin Oncol 26: 786-790. doi:10.1200/JCO.2008.15.0243. PubMed: 18258987.
6. Levine MN, Whelan T, (2006) Adjuvant chemotherapy for breast cancer--30 years later. N Engl J Med 355: 1920-1922. doi:10.1056/NEJMe068204. PubMed: 17079767.
7. Schröder KR, Wiebel FA, Reich S, Dannappel D, Bolt HM, et al. (1995) Glutathione-S-transferase (GST) theta polymorphism influences background SCE rate. Arch Toxicol 69: 505-507. doi:10.1007/s002040050205. PubMed: 8526747.
8. Hayes JD, Strange RC, (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 22: 193-207. doi:10.3109/10715769509147539. PubMed: 7757196.
9. Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, et al. (2005) Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metab Rev 37: 611-703. doi:10.1080/03602530500364023. PubMed: 16393888.
10. Townsend DM, Tew KD, (2003) The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22: 7369-7375. doi:10.1038/sj.onc.1206940. PubMed: 14576844.
11. Harries LW, Stubbins MJ, Forman D, Howard GC, Wolf CR, (1997) Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 18: 641-644. doi:10.1093/carcin/18.4.641. PubMed: 9111193.
12. Smith G, Stanley LA, Sim E, Strange RC, Wolf CR, (1995) Metabolic polymorphisms and cancer susceptibility. Cancer Surv 25: 27-65. PubMed: 8718512.
13. White DL, Li D, Nurgalieva Z, El-Serag HB, (2008) Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol 167: 377-389. doi:10.1093/aje/kwm315. PubMed: 18065725.
14. Kim SU, Lee KM, Park SK, Yoo KY, Noh DY, et al. (2004) Genetic polymorphism of glutathione S-transferase P1 and breast cancer risk. J Biochem Mol Biol 37: 582-585. doi:10.5483/BMBRep.2004.37.5.582. PubMed: 15479622.
15. Egan KM, Cai Q, Shu XO, Jin F, Zhu TL, et al. (2004) Genetic polymorphisms in GSTM1, GSTP1, and GSTT1 and the risk for breast cancer: results from the Shanghai Breast Cancer Study and meta-analysis. Cancer Epidemiol Biomarkers Prev 13: 197-204. doi:10.1158/1055-9965.EPI-03-0294. PubMed: 14973092.
16. Lee SA, Fowke JH, Lu W, Ye C, Zheng Y, et al. (2008) Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk. Am J Clin Nutr 87: 753-760. PubMed: 18326615.
17. Kadouri L, Kote-Jarai Z, Hubert A, Baras M, Abeliovich D, et al. (2008) Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers. Br J Cancer 98: 2006-2010. doi:10.1038/sj.bjc.6604394. PubMed: 18542066.
18. Saxena A, Dhillon VS, Raish M, Asim M, Rehman S, et al. (2009) Detection and relevance of germline genetic polymorphisms in glutathione S-transferases (GSTs) in breast cancer patients from northern Indian population. Breast Cancer Res Treat 115: 537-543. doi:10.1007/s10549-008-0098-y. PubMed: 18574688.
19. Samson M, Swaminathan R, Rama R, Sridevi V, Nancy KN, et al. (2007) Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the risk of breast cancer: a case control study from South India. Asian Pac J Cancer Prev 8: 253-257. PubMed: 17696741.
20. Vogl FD, Taioli E, Maugard C, Zheng W, Pinto LF, et al. (2004) Glutathione S-transferases M1, T1, and P1 and breast cancer: a pooled analysis. Cancer Epidemiol Biomarkers Prev 13: 1473-1479. PubMed: 15342448.
21. Curran JE, Weinstein SR, Griffiths LR, (2000) Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility. Cancer Lett 153: 113-120. doi:10.1016/S0304-3835(00)00361-X. PubMed: 10779639.
22. Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA, (1998) Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 19: 275-280. doi:10.1093/carcin/19.2.275. PubMed: 9498276.
23. Sivonova M, Waczulikova I, Dobrota D, Matakova T, Hatok J, et al. (2009). Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study. J Exp Clin Cancer Res 28: 32.
24. Hohaus S, Di Ruscio A, Di Febo A, Massini G, D'Alo' Fet al. (2005) Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. Clin Cancer Res 11: 2175-2179. doi:10.1158/1078-0432.CCR-04-1250. PubMed: 15788664.
25. Saxena A, Dhillon VS, Shahid M, Khalil HS, Rani M, et al. (2013) GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients. Exp Ther Med 4: 1097-1103. PubMed: 23226781.
26. Millikan R, Pittman G, Tse CK, Savitz DA, Newman B, et al. (2000) Glutathione S-transferases M1, T1, and P1 and breast cancer. Cancer Epidemiol Biomarkers Prev 9: 567-573. PubMed: 10868690.
27. Mitrunen K, Jourenkova N, Kataja V, Eskelinen M, Kosma VM, et al. (2001) Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer. Cancer Epidemiol Biomarkers Prev 10: 229-236.
28. Sergentanis TN, (2010) Economopoulos KP GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 121: 195-202. doi:10.1007/s10549-009-0520-0. PubMed: 19760040.
29. Hayes JD, Flanagan JU, Jowsey IR, (2005) Glutathione transferases. Annu Rev Pharmacol Toxicol 45: 51-88. doi:10.1146/annurev.pharmtox.45.120403.095857. PubMed: 15822171.
30. Yang G, Shu XO, Ruan ZX, Cai QY, Jin F, et al. (2005) Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma. Cancer 103: 52-58. doi:10.1002/cncr.20729. PubMed: 15565566.
31. Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, et al. (2010) Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer. Clin Cancer Res 16: 6169-6176. doi:10.1158/1078-0432.CCR-10-0281. PubMed: 21169260.
32. Dirven HA, van Ommen B, van Bladeren PJ, (1994) Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione. Cancer Res 54: 6215-6220. PubMed: 7954469.
33. Johansson AS, Stenberg G, Widersten M, Mannervik B, (1998) Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105. J Mol Biol 278: 687-698. doi:10.1006/jmbi.1998.1708. PubMed: 9600848.
34. Chen XH, Li XQ, Chen Y, Feng YM, (2011) Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China. Breast Cancer Res Treat 125: 575-582. doi:10.1007/s10549-010-1032-7. PubMed: 20640597.
35. Feng Y, Sun B, Li X, Zhang L, Niu Y, et al. (2007) Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients. Breast Cancer Res Treat 103: 319-329. doi:10.1007/s10549-006-9385-7. PubMed: 17123152.