Effects of combined treatment with ambroxol and ciprofloxacin on catheter-associated pseudomonas aeruginosa biofilms in a rat model

Chemotherapy

Volumn 59, Issue 1, 2013, Pages 51-56

  Lu, Qi ^a   Yu, Jialin ^a   Bao, Lei ^a   Ran, Tao ^a   Zhong, Haiying ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Ambroxol; Biofilm; Ciprofloxacin; Pseudomonas aeruginosa; Rat model

Indexed keywords

AMBROXOL; CIPROFLOXACIN; AGAR; EOSIN; HEMATOXYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIUM COLONY; BIOFILM; CATHETER INFECTION; CONTROLLED STUDY; DRUG EFFICACY; ENDOTRACHEAL INTUBATION; FEMALE; LUNG INFECTION; LUNG PARENCHYMA; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RAT; SCANNING ELECTRON MICROSCOPY; AEROSOL; BACTERIAL CLEARANCE; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; DISEASE ERADICATION; DRUG EFFECT; DRUG POTENTIATION; ENDOTRACHEAL TUBE; HISTOPATHOLOGY; STAINING;

EID: 84879475463     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000351107     Document Type: Article

References (27)

1. Davies JC: Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence. Paediatr Respir Rev 2002; 3: 128-134. (Pubitemid 35331506)
2. Cernada M, Aguar M, Brugada M, et al: Ventilator- associated pneumonia in newborn infants diagnosed with an invasive bronchoalveolar lavage technique: a prospective observational study. Pediatr Crit Care Med 2013; 14: 55-61.
3. Gilbert P, Allison DG, McBain AJ: Biofilms in vitro and in vivo: do singular mechanisms imply cross-resistance? J Appl Microbiol 2002; 92(suppl):98-110.
4. Rosen T: The fluoroquinolone antibacterial agents. Prog Med Chem 1990; 27: 235-295.
5. Soboh F, Khoury AE, Zamboni AC, Davidson D, Mittelman MW: Effects of ciprofloxacin and protamine sulfate combinations against catheter-associated Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 1995; 39: 1281-1286.
6. Yamada T, Takemura Y, Niisato N: Action of N-acylated ambroxol derivatives on secretion of chlorideions in human airway epithelia. Biochem Biophys Res Commun 2009; 380: 586-590.
7. Stetinová V, Herout V, Kvetina J: In vitro and in vivo antioxidant activity of ambroxol. Clin Exp Med 2004; 4: 152-158. (Pubitemid 40100911)
8. Yang H, Yu J, Liu G: Effect of ambroxol on permeability of ciprofloxacin across Pseudomonas aeruginosa biofilm. Chi J Antibioti 2007; 32: 221-224. (Pubitemid 46953492)
9. Li F, Yu J, Wan Z, Bai D: Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms. Curr Microbiol 2008; 57: 1-7.
10. Li F, Wang W, Hu L, Li L, Yu J: Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model. Chemotherapy 2011; 57: 173-180.
11. Kirschvink N, Leemans J, Delvaux F, Snaps F, Marlin D, Sparkes A, Clercx C, Gustin P: Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats. Vet J 2006; 172: 446-454.
12. Agbaht K, Diaz E, Muñoz E, Lisboa T, Gomez F, Depuydt PO, Blot SI, Rello J: Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: a study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia. Crit Care Med 2007; 35: 2064-2070. (Pubitemid 47326442)
13. Depuydt P, Myny D, Blot S: Nosocomial pneumonia: aetiology, diagnosis and treatment. Curr Opin Pulm Med 2006; 12: 192-197. (Pubitemid 44350474)
14. Augustyn B: Ventilator-associated pneumonia: risk factors and prevention. Crit Care Nurse 2007; 27: 32-36.
15. Heo SM, Haase EM, Lesse AJ, Gill SR, Scannapieco FA: Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation. Clin Infect Dis 2008; 47: 1562-1570.
16. Adair CG, Gorman SP, Feron BM, Byers LM, Jones DS, et al: Implications of endotracheal tube biofilm for ventilator-associated pneumonia. Intensive Care Med 1999; 25: 1072-1076. (Pubitemid 29525061)
17. Bauer TT, Torres A, Ferrer R, Heyer CM, Schultze-Werninghaus G, Rasche K: Biofilm formation in endotracheal tubes: association between pneumonia and the persistence of pathogens. Monaldi Arch Chest Dis 2002; 57: 84-87. (Pubitemid 34873746)
18. Inglis TJ, Millar MR, Jones JG, Robinson DA: Tracheal tube biofilm as a source of bacterial colonization of the lung. J Clin Microbiol 1989; 27: 2014-2018. (Pubitemid 19208985)
19. Sottile FD, Marrie TJ, Prough DS, Hobgood CD, Gower GJ, et al: Nosocomial pulmonary infection: possible etiologic significance of bacterial adhesion to endotracheal tubes. Crit Care Med 1986; 14: 265-270. (Pubitemid 16102040)
20. Davey P, Barza M, Stuart M: Tolerance of Pseudomonas aeruginosa to killing by ciprofloxacin, gentamicin and imipenem in vitro and in vivo. J Antimicrob Chemother 1988; 21: 395-404.
21. Jang CH, Park H, Cho YB, Choi CH, Park IY: The use of piperacillin-tazobactam coated tympanostomy tubes against ciprofloxacinresistant Pseudomonas biofilm formation: an in vitro study. Int J Pediatr Otorhinolaryngol 2009; 73: 295-299.
22. Yassien M, Khardori N, Ahmedy A, Toama M: Modulation of biofilms of Pseudomonas aeruginosa by quinolone. Antimicrob Agent Chemother 1995; 39: 2262-2268.
23. Mikuniya T, Kato Y, Ida T, Maebashi K, Monden K, Kariyama R, Kumon H: Treatment of Pseudomonas aeruginosa biofilms with a combination of fluoroquinolones and fosfomycin in a rat urinary tract infection model. J Infect Chemother 2007; 13: 285-290. (Pubitemid 350059914)
24. Reid G, Sharma S, Advikolanu K, Tieszer C, Martin RA, Bruce AW: Effects of ciprofloxacin, norfloxacin, and ofloxacin on in vitro adhesion and survival of Pseudomonas aeruginosa AK1 on urinary catheters. Antimicrob Agents Chemother 1994; 38: 1490-1495. (Pubitemid 24203557)
25. Song Z, Wu H, Ciofu O, Kong KF, Høiby N, Rygaard J, Kharazmi A, Mathee K: Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection. J Med Microbiol 2003; 52: 731-740. (Pubitemid 37174773)
26. Lu Q, Yu J, Yang X, Wang J, Wang L, Lin Y, Lin L: Ambroxol interferes with Pseudomonas aeruginosa quorum sensing. Int J Antimicrob Agents 2010; 36: 211-215.
27. Mittal R, Sharma S, Chhibber S, Harjai K: Contribution of quorum-sensing systems to virulence of Pseudomonas aeruginosa in an experimental pyelonephritis model. J Microbiol Immunol Infect 2006; 39: 302-309. (Pubitemid 44682776)