Disposition of the new potent acetylcholinesterase inhibitor 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidiny]-1-oxopropyl]-1, 2, 5, 6-tetrahydro-4 H-pyrrolo [3, 2, 1- ij ] quinolin-4-one (TAK-802) in rats, dogs and monkeys

Drug Research

Volumn 63, Issue 6, 2013, Pages 293-299

  Kakehi, M ^a   Tagawa, Y ^a   Kondo, T ^a   Asahi, S ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

ADME; concentration dependent; erythrocyte distribution; pharmacokinetics

Indexed keywords

8 [3 [1 [(3 F UOROPHENYL)METHYL] 4PIPERIDINY] 1 OXOPROPYL] 1, 2, 5, 6 TETRAHYDRO 4 H PYRROLO [3, 2, 1 IJ] QUINOLIN 4 ONE; CARBON 14; CHOLINESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BLADDER; CONCENTRATION (PARAMETERS); DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG POTENTIATION; DRUG SAFETY; ERYTHROCYTE; HAPLORHINI; HUMAN; MALE; NONHUMAN; PROTEIN BINDING; RAT; TARGET ORGAN;

EID: 84879474791     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0033-1337927     Document Type: Article

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