1α,25-dihydroxycholecalciferol (vitamin D3) induces NO-dependent endothelial cell proliferation and migration in a three-dimensional matrix

Cellular Physiology and Biochemistry

Volumn 31, Issue 6, 2013, Pages 815-822

  Molinari, Claudio ^a   Rizzi, Manuela ^a   Squarzanti, Diletta F ^a   Pittarella, Pamela ^a   Vacca, Giovanni ^a   Renò, Filippo ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

1 ,25 dihydroxycholecalciferol; Cell migration; Cell proliferation; Endothelial cells; Three dimensional matrix

Indexed keywords

CALCITRIOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE A; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; COLECALCIFEROL;

ANIMAL CELL; AORTA; ARTICLE; CELL ASSAY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR INTERACTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; ANGIOGENESIS; HUMAN; HUMAN CELL; PIG; TISSUE REPAIR; WOUND HEALING;

SUS;

EID: 84879470982     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000350099     Document Type: Article

References (30)

1. Ramesh KV, Mahindrakar MB, Bhat EP: A new role for vitamin D: cholecalciferol promotes dermal wound strength and re-epithelization. Indian J Exp Biol 1993;31:778-779. (Pubitemid 24084548)
2. Cooke GL, Chien A, Brodsky A, Lee RC: Incidence of hypertrophic scars among African Americans linked to vitamin D-3 metabolism? J Natl Med Assoc 2005;97:1004-1009. (Pubitemid 40967405)
3. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L: Vitamin D3: a helpful immuno-modulator. Immunology 2011;134:123-139.
4. Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M, Cisari C: 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem 2011;27:661-668.
5. Gurlek A, Pittelkow MR, Kumar R: Modulation of growth factor/cytokine synthesis and signaling by 1alpha, 25-dihydroxyvitamin D(3): implications in cell growth and differentiation. Endocr Rev 2002;23:763-786. (Pubitemid 35454588)
6. Merke J, Milde P, Lewicka S, Hügel U, Klaus G, Mangelsdorf DJ, Haussler MR, Rauterberg EW, Ritz E: Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J Clin Invest 1989;83:1903-1915. (Pubitemid 19148859)
7. Zehnder D, Bland R, Chana RS, Wheeler DC, Howie AJ, Williams MC, Stewart PM, Hewison M: Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 2002;13:621-629. (Pubitemid 34183926)
8. Chung I, Han G, Seshadri M, Gillard BM, Yu WD, Foster BA, Trump DL, Johnson CS: Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo. Cancer Res 2009;69:967-975.
9. Suzuki Y, Ichiyama T, Ohsaki A, Hasegawa S, Shiraishi M, Furukawa S: Anti-inflammatory effect of 1alpha, 25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol 2009;113:134-138.
10. Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS: 1α,25-Dihydroxyvitamin D(3)-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. J Neurochem 2012;123:944-953.
11. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE: 1α,25-dihydroxyvitamin D3 inhibits angiogenesis in vitro and in vivo. Circ Res 2000;87:214-220. (Pubitemid 30626429)
12. Bernardi RJ, Johnson CS, Modzelewski RA, Trump DL: Antiproliferative effects of 1α,25-dihydroxyvitamin D3 and vitamin D analogs on tumor derived endothelial cells. Endocrinology 2002;143:2508-2514. (Pubitemid 34701313)
13. Albert DM, Scheef EA, Wang S, Mehraein F, Darjatmoko SR, Sorenson CM, Sheibani N: Calcitriol is a potent inhibitor o retinal neovascularization. Invest Ophtalmol Vis Sci 2007;48:2327-2334. (Pubitemid 351261313)
14. Alemayehu A, Lock KR, Coatney RW, Chou CC: L-NAME, nitric oxide and jejunal motility, blood flow and oxygen uptake in dogs. Br J Pharmacol 1994;111:205-212. (Pubitemid 24148727)
15. Conners W, Whitebeck C, Chicester P, Legget R, Lin AD, Johnson A, Kogan B, Levin R, Mannikarottu A: L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction. Am J Physiol Renal Physiol 2006;290:F357-F363. (Pubitemid 43724990)
16. Küng CF, Moreau P, Takase H, Lüscher TF: L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil. Hypertension 1995;26:744-751.
17. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmernan GA, McEver Rp, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt Am, Stern DM: Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998;91:3527-3561. (Pubitemid 28225719)
18. Jones AM, Wilkerson DP, Campbell IT: Nitric oxide synthase inhibition with L-NAME reduces maximal oxygen uptake but not gas exchange threshold during incremental cycle exercise in man. J Physiol 2004;560:329-338. (Pubitemid 39406036)
19. Iwakiri Y: S-nitrosylation of proteins: a new insight into endothelial cell function regulated by eNOS-derived NO. Nitic Oxide 2011;25:95-101.
20. 2+ related pathways in endothelial cells. Cell Physiol Biochem 2009;23:87-96.
21. Castillo AI, Sánchez-Martinez R, Jiménez-Lara AM, Steinmeyer A, Zügel U, Arada A: Characterization of vitamin D receptor ligands with cell-specific and dissociated activity. Mol Endocr 2006;20:3093-3104. (Pubitemid 44833558)
22. Layman H, Spiga MG, Brooks T, Pham S, Webster KA, Andreopoulos FM: The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model. Biomaterials 2007;28:2646-2654. (Pubitemid 46367212)
23. Renò F, Rizzi M, Cannas M: Gelatin-based anionic hydrogel as biocompatible substrate for human keratinocyte growth. J Mater Sci Mater Med 2012;23:565-571.
24. Mujoo K, Krumenacker JS, Murad F: Nitric oxide-cyclic GMP signaling in stem cell differentiation. Free Radic Biol Med 2011;51:2150-2157.
25. Ikeda Y, Aihara K, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T: Heparin Cofactor II, a Serine Protease Inhibitor, Promotes Angiogenesis via Activation of the AMP-activated Protein Kinase-Endothelial Nitric-oxide Synthase Signaling Pathway. J Biol Chem 2012;287:34256-34263.
26. Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Módis K, Panopoulos P, Asimakopoulou A, Gerö D, Sharina I, Martin E, Szabo C: Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc Natl Acad Sci USA 2012;109:9161-9166.
27. Resente RY, Egitto P, Calabrese GGC: Low molecular mass dermatan sulfate modulates endothelial cells proliferation and migration. Carbohydrate Res 2012;356:233-237.
28. Gao H, Zhang J, Liu T, Shi W: Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and -9: an in vitro study. Mol Vis 2011;17:3406-3414.
29. Cavdar Z, Oktay G, Egrilmez MY, Genc S, Genc K, Altun Z, Islekel H, Guner G: In vitro reoxygenation following hypoxia increases MMP-2 and TIMP-2 secretion by human umbilical vein endothelial cells. Acta Biochimica Polonica 2010;57:69-73.
30. Li H, Daculsi R, Bareille R, Bourget C, Amedee J: uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells. J Cell Biochem 2013;114:650-657.