Measurement of Cancer Cell Growth Heterogeneity through Lentiviral Barcoding Identifies Clonal Dominance as a Characteristic of In Vivo Tumor Engraftment

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Nolan Stevaux, Olivier ^a   Tedesco, Donato ^b   Ragan, Seamus ^a   Makhanov, Mikhail ^b   Chenchik, Alex ^b   Ruefli Brasse, Astrid ^a   Quon, Kim ^c   Kassner, Paul D ^a  

^a AMGEN INC   (United States)

^b Cellecta Inc   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CLONAL VARIATION; CONTROLLED STUDY; DNA BARCODING; HIGH THROUGHPUT SEQUENCING; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MOUSE; NONHUMAN; REPRODUCIBILITY; TUMOR ENGRAFTMENT; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CELL CLONE; CELL PROLIFERATION; CELL TRANSFORMATION; FEMALE; GENETIC TRANSDUCTION; GENETICS; HCT 116 CELL LINE; HUMAN; PATHOLOGY;

ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; FEMALE; HCT116 CELLS; HUMANS; LENTIVIRUS; MICE; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC;

EID: 84879467613     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067316     Document Type: Article

References (24)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF, (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100: 3983-3988.
2. O'Brien CA, Pollett A, Gallinger S, Dick JE, (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110.
3. Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, et al. (2008) Efficient tumour formation by single human melanoma cells. Nature 456: 593-598.
4. Shackleton M, Quintana E, Fearon ER, Morrison SJ, (2009) Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138: 822-829.
5. Meacham CE, Ho EE, Dubrovsky E, Gertler FB, Hemann MT, (2009) In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat Genet 41: 1133-1137.
6. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, et al. (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476: 346-350.
7. Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, et al. (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478: 524-528.
8. Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, et al. (2013) A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration. Cell 153: 389-401.
9. Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, et al. (2008) An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135: 852-864.
10. Serganova I, Doubrovin M, Vider J, Ponomarev V, Soghomonyan S, et al. (2004) Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer Res 64: 6101-6108.
11. Erez N, Truitt M, Olson P, Arron ST, Hanahan D, (2010) Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell 17: 135-147.
12. Morgan JR, LeDoux JM, Snow RG, Tompkins RG, Yarmush ML, (1995) Retrovirus infection: effect of time and target cell number. J Virol 69: 6994-7000.
13. Arai T, Takada M, Ui M, Iba H, (1999) Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts. Virology 260: 109-115.
14. Luria SE, Darnell JE, Baltimore D, Campbell A (1978) General Virology. New York: Wiley.
15. Fehse B, Kustikova OS, Bubenheim M, Baum C, (2004) Pois(s)on-it's a question of dose. Gene Ther 11: 879-881.
16. Yeung TM, Gandhi SC, Wilding JL, Muschel R, Bodmer WF, (2010) Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci U S A 107: 3722-3727.
17. Kai K, Nagano O, Sugihara E, Arima Y, Sampetrean O, et al. (2009) Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model. Cancer Sci 100: 2275-2282.
18. Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, et al. (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146: 633-644.
19. Minchinton AI, Tannock IF, (2006) Drug penetration in solid tumours. Nat Rev Cancer 6: 583-592.
20. Kreso A, O'Brien CA, van Galen P, Gan O, Notta F, et al. (2012) Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer. Science.
21. Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A, (2007) Tumor growth need not be driven by rare cancer stem cells. Science 317: 337.
22. Kennedy JA, Barabe F, Poeppl AG, Wang JC, Dick JE (2007) Comment on "Tumor growth need not be driven by rare cancer stem cells". Science 318: 1722; author reply 1722.
23. Kaelin WG Jr, (2012) Molecular biology. Use and abuse of RNAi to study mammalian gene function. Science 337: 421-422.
24. Jackson AL, Linsley PS, (2010) Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 9: 57-67.