Ethanol inhibits excitatory neurotransmission in the nucleus accumbens of adolescent mice through GABAA and GABAB receptors

Addiction Biology

Volumn 18, Issue 4, 2013, Pages 605-613

  Mishra, Devesh ^a   Chergui, Karima ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alcohol; field excitatory postsynaptic potentials; GABAA receptor; GABAB receptor; glutamate; nucleus accumbens

Indexed keywords

3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ALCOHOL; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; BICUCULLINE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; EXCITATORY POSTSYNAPTIC POTENTIAL; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; STIMULATION; SYNAPTIC TRANSMISSION;

ADOLESCENT; ADULT; AGE FACTORS; ANIMALS; BICUCULLINE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; GABA-A RECEPTOR AGONISTS; HUMANS; MALE; MICE; MUSCIMOL; NUCLEUS ACCUMBENS; PHOSPHINIC ACIDS; PROPANOLAMINES; RECEPTORS, GABA; REWARD; SYNAPTIC TRANSMISSION;

EID: 84879461962     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2011.00350.x     Document Type: Article

References (31)

1. Akhondzadeh S, Stone T, (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br J Pharmacol 115: 527-533.
2. Buckby LE, Lacey MG, (2001) Epileptiform activity in the nucleus accumbens induced by GABA(A) receptor antagonists in rat forebrain slices is of cortical origin. Exp Brain Res 141: 146-152. (Pubitemid 33020843)
3. Clark DB, Thatcher DL, Tapert SF, (2008) Alcohol, psychological dysregulation, and adolescent brain development. Alcohol Clin Exp Res 32: 375-385. (Pubitemid 351301000)
4. Doremus-Fitzwater TL, Varlinskaya EI, Spear LP, (2010) Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn 72: 114-123.
5. Gonzales RA, Job MO, Doyon WM, (2004) The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol Ther 103: 121-146. (Pubitemid 39209040)
6. Hefner K, Holmes A, (2007) An investigation of the behavioral actions of ethanol across adolescence in mice. Psychopharmacology 191: 311-322. (Pubitemid 46354607)
7. Hyman SE, Malenka RC, Nestler EJ, (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29: 565-598. (Pubitemid 44476856)
8. Jeanes Z, Buske T, Morrisett R, (2011) In vivo chronic intermittent ethanol exposure reverses the polarity of synaptic plasticity in the nucleus accumbens shell. J Pharmacol Exp Ther 336: 155-164.
9. Kullmann DM, Ruiz A, Rusakov DM, Scott R, Semyanov A, Walker MC, (2005) Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why? Prog Biophys Mol Biol 87: 33-46. (Pubitemid 39308540)
10. Kumar S, Porcu P, Werner D, Matthews D, Diaz-Granados J, Helfand R, Morrow A, (2009) The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology 205: 529-564.
11. Laurie D, Wisden W, Seeburg P, (1992) The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 12: 4151-4172.
12. Laviola G, Macrì S, Morley-Fletcher S, Adriani W, (2003) Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence. Neurosci Biobehav Rev 27: 19-31. (Pubitemid 36535388)
13. Nicola SM, Kombian SB, Malenka RC, (1996) Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors. J Neurosci 16: 1591-1604. (Pubitemid 26145937)
14. Nie Z, Madamba SG, Siggins GR, (2000) Ethanol enhances gamma-aminobutyric acid responses in a subpopulation of nucleus accumbens neurons: role of metabotropic glutamate receptors. J Pharmacol Exp Ther 293: 654-661. (Pubitemid 30244120)
15. Nie Z, Yuan X, Madamba SG, Siggins GR, (1993) Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal. J Pharmacol Exp Ther 266: 1705-1712. (Pubitemid 24175825)
16. Olsen RW, Hanchar HJ, Meera P, Wallner M, (2007) GABAA receptor subtypes: The 'one glass of wine' receptors. Alcohol 41: 201-209. (Pubitemid 46964889)
17. Pennartz CM, Boeijinga PH, Lopes da Silva FH, (1990) Locally evoked potentials in slices of the rat nucleus accumbens: NMDA and non-NMDA receptor mediated components and modulation by GABA. Brain Res 529: 30-41. (Pubitemid 20326837)
18. Philpot RM, Badanich KA, Kirstein CL, (2003) Place conditioning: age-related changes in the rewarding and aversive effects of alcohol. Alcohol Clin Exp Res 27: 593-599. (Pubitemid 36460698)
19. Pinard A, Seddik R, Bettler B, Thomas PB, (2010) GABAB receptors: physiological functions and mechanisms of diversity. In:, Blackburn TP, Enna SJ, eds. Advances in Pharmacology, pp. 231-255. Maryland Heights, MO: Academic Press.
20. Santhakumar V, Wallner M, Otis TS, (2007) Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition. Alcohol 41: 211-221. (Pubitemid 46970812)
21. Schotanus SM, Chergui K, (2008a) Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens. Neuropharmacology 54: 837-844.
22. Schotanus SM, Chergui K, (2008b) Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-d-aspartate receptors. Eur J Neurosci 27: 1957-1964. (Pubitemid 351521491)
23. Schotanus SM, Chergui K, (2008c) NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum. J Neurochem 106: 1758-1765.
24. Schotanus SM, Fredholm BB, Chergui K, (2006) NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice. Neuropharmacology 51: 272-282. (Pubitemid 44061891)
25. Siggins GR, Roberto M, Nie Z, (2005) The tipsy terminal: presynaptic effects of ethanol. Pharmacol Ther 107: 80-98. (Pubitemid 40800409)
26. Spear LP, (2002) The adolescent brain and the college drinker: biological basis of propensity to use and misuse alcohol. J Stud Alcohol 14: 71-81. (Pubitemid 34441593)
27. Spear LP, Varlinskaya EI, (2010) Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science? Dev Psychobiol 52: 236-243.
28. Stõrustovu S, Ebert B, (2006) Pharmacological Characterization of agonists at delta-containing GABAA receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of gamma 2. J Pharmacol Exp Ther 316: 1351-1359. (Pubitemid 43345312)
29. Vengeliene V, Bilbao A, Molander A, Spanagel R, (2008) Neuropharmacology of alcohol addiction. Br J Pharmacol 154: 299-315. (Pubitemid 351670598)
30. Weiner JL, Valenzuela CF, (2006) Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol Ther 111: 533-554. (Pubitemid 44164382)
31. Wolf ME, Sun X, Mangiavacchi S, Chao SZ, (2004) Psychomotor stimulants and neuronal plasticity. Neuropharmacology 47 (Suppl 1): 61-79. (Pubitemid 39298253)