Possible involvement of prolonging spinal μ-opioid receptor desensitization in the development of antihyperalgesic tolerance to μ-opioids under a neuropathic pain-like state

Addiction Biology

Volumn 18, Issue 4, 2013, Pages 614-622

  Narita, Minoru ^a   Imai, Satoshi ^a   Nakamura, Atsushi ^a   Ozeki, Ayumi ^a   Asato, Megumi ^a   Rahmadi, Mahardian ^a   Sudo, Yuka ^b   Hojo, Minoru ^c   Uezono, Yasuhito ^b,d   Devi, Lakshmi A ^e   Kuzumaki, Naoko ^a   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

opioid receptor; Fentanyl; mouse; neuropathic pain; opioid tolerance; spinal cord

Indexed keywords

BETA ENDORPHIN; FENTANYL CITRATE; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; MU OPIATE RECEPTOR; OXYCODONE; PROOPIOMELANOCORTIN;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; FEMALE; KNOCKOUT MOUSE; MALE; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; SCIATIC NERVE; SPINAL CORD; WILD TYPE;

ANALGESICS, OPIOID; ANIMALS; BETA-ENDORPHIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; FEMALE; FENTANYL; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; LIGATION; MALE; MICE; MICE, KNOCKOUT; MORPHINE; NEURALGIA; OXYCODONE; PAIN MEASUREMENT; PAIN THRESHOLD; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SCIATIC NERVE; SODIUM CHLORIDE; SPINAL CORD;

EID: 84879460537     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2011.00354.x     Document Type: Article

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