Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: A prospective study

Osteoarthritis and Cartilage

Volumn 21, Issue 7, 2013, Pages 923-929

  Blumenfeld, O ^a   Williams, F M K ^b   Hart, D J ^b   Spector, T D ^b   Arden, N ^c   Livshits, G ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aggrecan; CIAP; COMP; NTx; RKOA

Indexed keywords

AGGRECAN; AMINO TERMINAL TELOPEPTIDE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN;

ADULT; ARTICLE; BODY MASS; CARTILAGE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MEDICAL DOCUMENTATION; PHENOTYPE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIOGRAPHIC KNEE OSTEOARTHRITIS; SCORING SYSTEM; UNITED KINGDOM;

AGE FACTORS; AGGRECANS; BODY MASS INDEX; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE I; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INHIBITOR OF APOPTOSIS PROTEINS; KNEE JOINT; LONDON; MIDDLE AGED; OSTEOARTHRITIS, KNEE; OSTEOPHYTE; PEPTIDES; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84879459574     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.04.009     Document Type: Article

References (46)

1. Miller G.D., Nicklas B.J., Loeser R.F. Inflammatory biomarkes and physical function in older obese adults with knee pain and self-reported osteoarthritis after intensive weight loss therapy. Am Geriat Soc 2008, 56:644-651.
2. Arden N., Nevitt M.C. Osteoarthritis epidemiology. Best Pract Res Clin Rheumatol 2006, 20:3-25.
3. Garstang S.V., Sittik T.P. Osteoarthritis: epidemiology risk factors and path physiology. Am J Phys Med Rehabil 2006, 85:S2-11.
4. Huber M., Tratting S., Lintner F. Anatomy biochemistry and physiology of articular cartilage. Invest Radiol 2000, 35:573-580.
5. Garnero P., Ayral X., Rousseau J.C., Christgau S., Sandell L.J., Dougados M., et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 2002, 46:2613-2624.
6. Livshits G., Ermakov S., Vilker A. Outlines of the biochemistry of osteoarthritis. Curr Rheum Rev 2010, 6(4):234-250.
7. De Ceuninck F., Sabatini M., Pastoureau P. Recent progress toward biomarker identification in osteoarthritis. Dru Discov Today 2011, 16(9-10):443-449.
8. Dam F.B., Long M., Christansen C., Byrjalsen I., Folkesson J., Nielsen M., et al. Identification of progressors in osteoarthritis by combining biochemical and MRI based markers. Arthritis Res Ther 2009, 11(4):R115.
9. Williams F.M. Biomarkers: in combination they may do better. Arthritis Res Ther 2009, 11(5):130.
10. Rousseau J.C., Delmas P.D. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 2007, 3:346-356.
11. Kraus V.B., Burnett B., Coindreau J., Cottrell S., Eyre D., Gendreau M. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 2011, 19:515-542.
12. Kiant C., Chen L., Wa Y.J., Yee A.J., Yang B.B. Structure and function of aggrecan. Cell Res 2002, 12(1):19-32.
13. Lohmanders L.S., Ionescu M., Jugessur H., Poole R. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 1999, 42(3):534-544.
14. Fraser A., Fearson U., Billinghurst R.C., Ionescu M., Reece R., Barwick T., et al. Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans. Arthritis Rheum 2003, 48(11):3085-3095.
15. Kraus V.B., Kepler T.B., Stabler T., Renner J., Jordan J. First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis. PloS One 2010, 5(3):e9739. 1-11.
16. Berry P.A., Maciewicz R.A., Wluka A.E., Downey-Jones M.D., Forbs A., Hellawell C.J., et al. Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure. Ann Rheum Dis 2010, 69:1816-1822.
17. Fosang A.J., Rogerson F.M. Identifying the human aggrecanase. Osteoarthritis Cartilage 2010, 18:1109-1116.
18. Struglics A., Larsson S., Hansson M., Lohmander L.S. Western blot quantification of aggrecan in human synovial fluid indicates difference in fragment patterns between joint diseases. Osteoarthritis Cartilage 2009, 17:497-506.
19. Struglics A., Hansson M., Lohmander L.S. Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter-globular and chondroitin sulfate domains. Osteoarthritis Cartilage 2011, 19:1047-1057.
20. Larsson S., Englund M., Sruglics A., Lohmander L.S. The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study. Osteoarthritis Cartilage 2012, 20(5):388-395.
21. Kalai E., Bahlous A., Charni N., Bouzid K., Sahli H., Laadhar L., et al. Association of serum levels of aggrecan ARGS, NITEGE fragments and radiologic knee osteoarthritis in Tunisian patients. Joint Bone Spine 2012, 79(6):610.
22. Ei-Arman M., Ei-Fayoumi G., Ei-Boghdady I., Ei-Ghaweet A. Aggrecan and cartilage oligomeric matrix protein in serum and synovial fluid of patients with knee osteoarthritis. HSSJ 2010, 6:171-176.
23. Chockalingam P.S., Sun W., Rivera-Bermudez M.A., Zeng W., Dufield D.R., Larsson S., et al. Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage 2011, 19:315-323.
24. Hunter D.J., Li J., Lavalley M. Cartilage markers and their association with cartilage loss of magnetic resonance imaging in knee osteoarthritis. The Boston osteoarthritis knee study. Arthritis Res Ther 2007, 9:R108.
25. Mobasheri A., Henrotin Y. Biomarkers of osteoarthritis: a review of recent research progress on soluble biochemical markers published patents and areas for future development. Recent Patents Biomark 2011, 1:25-43.
26. Hoch J.M., Mattacola C.G., Medina Mckeon J.M., Howard J.S., Lattermann C. Serum cartilage oligomeric matrix protein (s COMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage 2011, 19:1396-1404.
27. Cibere J., Zhang H., Garnero P., Poole A.R., Lobanok t, Sarne T. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in population -based study. Arthritis Rheum 2009, 60(5):1372-1380.
28. Mundermann A., King K.B., Smith R.L., Andracchi T.P. Changes in serum comp concentration due to ambulatory load is not related to knee OA status. JOrthop Res 2009, 27(11):1408-1413.
29. Szulc P., Seeman E., Delmas P.D. Biochemical measurements of bone turnover in children and adolescents. Ostoporosis Int 2000, 11:281-294.
30. Dequeker J., Aerssens J., Luyten F.P. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 2003, 15(5):426-439.
31. Betica P., Cline G., Hart D.J., Meyer J., Spector T.D. Evidence for increased bone resorption in patients with progressive knee osteoarthritis - longitudinal results from the Chingford study. Arthritis Rheum 2002, 46(12):3178-3184.
32. Tanishi N., Yamagiwa H., Hayami T., Mera H., Koga Y., Omri G., et al. Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (urine CTX-II and NTX-I): the Matsudai knee osteoarthritis survey. JBone Miner Metab 2009, 27:605-612.
33. Garnero P., Aronstein W.S., Cohen S.B., Conaghan P.G., Cline G.A., Christiansen C., et al. Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the knee osteoarthritis structural arthritis randomized clinical trial. Osteoarthritis Cartilage 2008, 16:660-666.
34. Hart D.J., Spector T.D. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. JRheumatol 1993 Feb, 20(2):331-335.
35. Spector T.D., Hart D.J., Nandra D., Doyle D.V., Mackillop N., Gllmore J.R., et al. Low level increase in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997, 40(4):723-727.
36. Altman R., Gold G. Atlas of individual radiographic features in osteoarthritis, revised1. Osteoarthritis Cartilage 2007, 15:A1-A56.
37. Rousseau J.C., Sumer E.U., Hein G., Sondergaard B.C., Madsen S.H., Pedersen C., et al. Patients with rheumatoid arthritis have an altered circulatory aggrecan profile. Musculoskelet Disord 2008, 9:74.
38. Larsson S., Englund M., Struglics A. Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis. Arthritis Res Ther 2010, 12:R230.
39. Lohmanders L.S., Saxne T., Heinegard D.K. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis. Ann Rheum Dis 1994, 53:8-13.
40. Recklies A.D., Baillargeon L., White C. Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular or phasic progression in human synovial cells and articular chondroctes. Arthritis Rheum 1998, 41:997-1006.
41. Jordan J.M. Cartilage oligomeric matrix protein as a marker of osteoarthritis. JRheumatol Suppl 2004, 70:45-49.
42. Tseng S., Reddi A.H., Di Cesare P.E. Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis. Biomark Insights 2009, 4:33-44.
43. Williams F.M.K., Andrew T., Saxne T., Heinegard D., Spector T.D., MacGregor A.J. The heritable determinants of cartilage oligomeric matrix protein. Arthitis Rheum 2006, 54(7):2147-2151.
44. Sharif M., Kirwan J.R., Elson C.J., Granell R., Clarke S. Suggestion of nonlinear phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years. Arthitis Rheum 2004, 50:2479-2488.
45. Ling S.M., Patel D.D., Garnero P., Zhai M., Vaduganathan M., Muller D., et al. Serum protein signature detect early radiographic osteoarthritis. Osteoarthritis Cartilage 2009, 17:43-48.
46. Golightly Y., Marshall S., Kraus V., Renner J., Villaveces A., Casteel C., et al. Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?. Arthritis Rheum 2011 Aug, 63(8):2276-2283.