Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model

Journal of Glaucoma

Volumn 22, Issue 2, 2013, Pages 145-151

  Lukowski, Zachary L ^a   Min, Jeff ^a   Beattie, Ashley R ^a   Meyers, Craig A ^a   Levine, Monica A ^a   Stoller, Glenn ^d,e   Schultz, Gregory S ^b   Samuelson, Don A ^c   Sherwood, Mark B ^a,f  

^a Department of Ophthalmology ^*  (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c University of Florida   (United States)

^d Lpath Inc   (United States)

^e OPHTHALMIC CONSULTANTS OF LONG ISLAND   (United States)

^f not available   (United States)

Author keywords

Anti S1P monoclonal antibody; Glaucoma; Rabbit model; Wound healing

Indexed keywords

MITOMYCIN; SONEPCIZUMAB; ALKYLATING AGENT; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; MONOCLONAL ANTIBODY; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL RABBIT; EYELID EDEMA; GLAUCOMA FILTERING SURGERY; GLAUCOMA SURGERY; HISTOPATHOLOGY; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SCAR FORMATION; SURVIVAL RATE; TREATMENT DURATION; TREATMENT OUTCOME; WOUND HEALING; ANIMAL; DISEASE MODEL; FIBROSIS; FILTERING OPERATION; GLAUCOMA; IMMUNOLOGY; INJECTION; PATHOLOGY; POSTOPERATIVE COMPLICATION; RABBIT; SCAR; SURGICALLY CREATED STRUCTURE;

ALKYLATING AGENTS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CICATRIX; CONJUNCTIVA; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROSIS; FILTERING SURGERY; GLAUCOMA; INJECTIONS; LYSOPHOSPHOLIPIDS; MITOMYCIN; POSTOPERATIVE COMPLICATIONS; RABBITS; SPHINGOSINE; SURGICALLY-CREATED STRUCTURES; WOUND HEALING;

MLCS; MLOWN;

EID: 84879438061     PISSN: 10570829     EISSN: 1536481X     Source Type: Journal    
DOI: 10.1097/IJG.0b013e31822e8c83     Document Type: Article

References (18)

1. Muckley ED, Lehrer RA. Late-onset blebitis/endophthalmitis: incidence and outcomes with mitomycin C. Optom Vis Sci. 2004; 81:499-504.
2. Francis BA, Du LT, Najafi K, et al. Histopathologic features of conjunctival filtering blebs. Arch Ophthalmol. 2005;123:166-170.
3. Bindlish R, Condon GP, Schlosser JD, et al. Efficacy and safety of mitomycin-C in primary trabeculectomy: five year follow-up. Ophthalmology. 2002;109:1336-1341.
4. Anand N, Arora S, Clowes M. Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. Br J Ophthalmol. 2006;90:175-180.
5. Beckers HJ, Kinders KC, Webers CA. Five-year results of trabeculectomy with mitomycin C. Graefes Arch Clin Exp Opthalmol. 2003;241:106-110.
6. DeBry PW, Perkins TW, Heatley G, et al. Incidence of lateonset bleb-related complications following trabeculectomy with mitomycin. Arch Ophthalmol. 2002;120:297-300.
7. Skoura A, Sanchez T, Claffey K, et al. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest. 2007;117:2506-2516.
8. Swaney JS, Moreno KM, Gentile AM, et al. Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res. 2008;87:367-375.
9. O'Brien N, Jones ST, Williams DG, et al. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res. 2009;50:2245-2257.
10. Wymann MP, Schneiter R. Lipid signaling in disease. Nat Rev Mol Cell Biol. 2008;9:162-176.
11. Gardell SE, Dubin AE, Chun J. Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med. 2006;12: 65-75.
12. Murph M, Mills GB. Targeting the lipids LPA and S1P and their signaling pathways to inhibit tumour progression. Expert Rev Mol Med. 2007;15:1-18.
13. Cordeiro MF, Constable PH, Alexander RA, et al. Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit. Invest Ophthalmol Vis Sci. 1997;38: 1639-1646.
14. Sherwood MB, Esson DW, Neelakantan A, et al. A new model of glaucoma filtering surgery in the rat. J Glaucoma. 2004; 13:407-412.
15. Doyle JW, Sherwood MB, Khaw PT, et al. Intraoperative 5-fluorouracil for filtration surgery in the rabbit. Invest Ophthalmol Vis Sci. 1993;34:3313-3319.
16. Connon CJ, Meek KM. Organization of corneal collagen fibrils during the healing of trephined wounds in rabbits. Wound Repair Regen. 2003;11:71-78.
17. Khaw PT, Doyle JW, Sherwood MB, et al. Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit. Ophthalmology. 1993;100: 367-372.
18. Liang SY, Lee GA, Whitehead K. Histopathology of a functioning mitomycin-C trabeculectomy. Clin Experiment Ophthalmol. 2009;37:316-319.