Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. A double-blind randomized trial

Journal of Gastroenterology

Volumn 48, Issue 6, 2013, Pages 698-705

  Bonelli, Luigina ^a   Puntoni, Matteo ^b   Gatteschi, Beatrice ^a   Massa, Paolo ^b   Missale, Guido ^c   Munizzi, Francesco ^a   Turbino, Laura ^b   Villanacci, Vincenzo ^d   De Censi, Andrea ^b   Bruzzi, Paolo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b GALLIERA HOSPITAL   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d Spedali Civili di Brescia   (Italy)

Author keywords

Antioxidants; Large bowel; Recurrent adenoma

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; PLACEBO; RETINOL; SELENIUM; TRACE ELEMENT; ZINC;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER INCIDENCE; CANCER RISK; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; ITALY; LARGE INTESTINE TUMOR; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PHASE 3 CLINICAL TRIAL; POLYPECTOMY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RECURRENT CANCER; RISK REDUCTION; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR RECURRENCE; VITAMIN SUPPLEMENTATION;

ADENOMATOUS POLYPS; ADULT; AGED; AGED, 80 AND OVER; ANTIOXIDANTS; COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTESTINE, LARGE; MALE; MICRONUTRIENTS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; SELENIUM; VITAMINS; ZINC;

EID: 84879420942     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0691-z     Document Type: Article

References (34)

1. Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer. 2010;46:65-81.
2. Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg. 2002;89:845-60.
3. Cairns SR, Scholefield JH, Steele RJ, et al.; British Society of Gastroenterology; Association of Coloproctology for Great Britain and Ireland. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut. 2010;59:666-89.
4. Salonen JT, Alfthan G, Huttunen JK, Puska P. Association between serum selenium and the risk of cancer. Am J Epidemiol. 1984;120:342-9.
5. Salonen JT, Salonen R, Lappeteläinen R, Mäenpää PH, Alfthan G, Puska P. Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. Br Med J. 1985;290:417-20.
6. Nomura A, Heilbrun LK, Morris JS, Stemmermann GN. Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J Natl Cancer Inst. 1987;79:103-8.
7. Wald NJ, Thompson SG, Densem JW, Boreham J, Baley A. Serum beta-carotene, and subsequent the risk of cancer: results from the BUPA study. Br J Cancer. 1988;57:428-33.
8. Birt DF, Lawson TA, Julius AD, Runice CE, Salmasi S. Inhibition by dietary selenium of colon cancer induced in the rat by bis (2-oxopropil) nitrosamine. Cancer Res. 1982;42:4455-9.
9. Reddy BS, Sugie S, Maruyama S, El-Bayomy K, Marra P. Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats. Cancer Res. 1987;47:5901-4.
10. Dion PW, Bright-See EB, Smith CC, Bruce WR. The effect of dietary ascorbic acid and a-Tocopherol on fecal mutagenicity. Mutat Res. 1982;102:27-37.
11. Song MK, Adham NF, Heng MC, Costea NV, Heng MK, Ament ME. Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells. J Am Coll Nutr. 1995;14:473-9.
12. Bonelli L, Camoriano A, Ravelli P, Missale G, Bruzzi P, Aste H. Reduction of the incidence of recurrent adenomas of the large bowel by means of antioxidants. In: Palmieri Y, editor. Proceedings of International Selenium Tellurium Development Association. Brussels, Belgium: Se-Te Press; 1998. p. 91-4.
13. Freedman LS, Green SB. Statistical design for investigating several interventions in the same study: methods for cancer prevention trials. J Natl Cancer Inst. 1990;82:910-4.
14. Morson BC, Sobin LH. Histological typing of intestinal tumours. Geneva: World Health Organization; 1976. (International histological classification of tumours no. 15).
15. Jass J, Sobin LH. Histological typing of intestinal tumours. II ed. Berlin: Springer; 1989.
16. Morson BC, Bussey HT. Magnitude of risk for cancer in patients with colorectal adenomas. Br J Surg. 1985;72:S23-5.
17. McKeown-Eyssen G, Holloway C, Jazmaji V, Bright-See E, Dion P, Bruce WR. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res. 1988;48:4701-5.
18. Greenberg ER, Baron JA, Tosteson TD, Polyp Prevention Study Group, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med. 1994;331:141-7.
19. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-81.
20. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patients: II Analysis and examples. Br J Cancer. 1977;35:1-39.
21. Cox DR. Regression model and life-tables. J R Stat Soc B. 1972;34:187-220.
22. Malila N, Virtamo J, Virtanen M, Albanes D, Tangrea JA, Huttunen JK. The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers. Cancer Epidemiol Biomarkers Prev. 1999;8:489-93.
23. Albanes D, Malila N, Taylor PR, Huttunen JK, Virtamo J, Edwards BK. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control. 2000;11:197-205.
24. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev. 2008;3:CD004183. Review.
25. Baron JA, Cole BF, Mott L, Haile R, Grau M, Church TR, et al. Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma recurrence: results of a randomized trial. J Natl Cancer Inst. 2003;95:717-22.
26. Roncucci L, Di Donato P, Carati L, Colorectal Cancer Study Group of the University of Modena and the Health Care District 16, et al. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Dis Colon Rectum. 1993;36:227-34.
27. Hofstad B, Almendingen K, Vatn M, et al. Growth and recurrence of colorectal polyps: a double-blind 3-year intervention with calcium and antioxidants. Digestion. 1998;59:148-56.
28. Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276:1957-63.
29. Duffield-Lillico AJ, Reid ME, Turnbull BW, et al. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev. 2002;11:630-9.
30. Reid ME, Duffield-Lillico AJ, Sunga A, Fakih M, Alberts DS, Marshall JR. Selenium supplementation and colorectal adenomas: an analysis of the nutritional prevention of cancer trial. Int J Cancer. 2006;118:1777-81.
31. Jacobs ET, Jiang R, Alberts DS, Greenberg ER, Gunter EW, Karagas MR. Selenium and colorectal adenoma: results of a pooled analysis. J Natl Cancer Inst. 2004;96:1669-75.
32. Peters U, Chatterjee N, Church TR, et al. High serum selenium and reduced risk of advanced colorectal adenoma in a colorectal cancer early detection program. Cancer Epidemiol Biomarkers Prev. 2006;15:315-20.
33. Stewart MS, Davis RL, Walsh LP, Pence BC. Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Lett. 1997;117:35-40.
34. Goulet AC, Chigbrow M, Frisk P, Nelson MA. Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells. Carcinogenesis. 2005;26:109-17.