Growth and recurrence of colorectal polyps: A double-blind 3-year intervention with calcium and antioxidants

Digestion

Volumn 59, Issue 2, 1998, Pages 148-156

  Hofstad, Bjorn ^a   Aimendingen, Kari ^a   Vatn, Mort En ^b   Andersen, Solveig Norheim ^c   Owen, Robert W ^d   Larsen, Stig ^e   Osnes, Magne ^a  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

^e Medstat Research   (Norway)

Author keywords

Antioxidants; Calcium; Colorectal adenomas; Growth; Intervention; Recurrence

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; RETINOL;

ADENOMA; AGED; ARTICLE; CALCIUM INTAKE; CALORIC INTAKE; CELL DIVISION; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; COLON POLYP; COLORECTAL TUMOR; CONSTIPATION; DIARRHEA; DIET; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DYSPEPSIA; FEMALE; FOLLOW UP; GASTROINTESTINAL DISEASE; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; PATIENT; PATIENT COMPLIANCE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TIME; TUMOR RECURRENCE;

ADENOMA; AGED; ANTIOXIDANTS; ASCORBIC ACID; CALCIUM, DIETARY; CELL DIVISION; COLONIC POLYPS; COLORECTAL NEOPLASMS; CONSTIPATION; DIARRHEA; DIET; DOUBLE-BLIND METHOD; DYSPEPSIA; ENERGY INTAKE; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL DISEASES; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PATIENT COMPLIANCE; PATIENT DROPOUTS; PROSPECTIVE STUDIES; TIME FACTORS; VITAMIN A;

EID: 0031637615     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007480     Document Type: Article

References (71)

1. Teppo L, Saxen E: Epidemiology of colon cancer in Scandinavia. J Med Sei 1979; 15:322-323.
2. McKeown-Eysscn GE, Bright-See E: Dietary factors in colon cancer: International relationships. Nutr Cancer 1984;6:160-170.
3. Macquart-Moulin G, Riboli E, Cornee J: Case-control study on colorectal cancer and diet in Marseilles. IntJ Cancer 1986;38:183-19l.
4. Kune S, Kune GA, Watson LF: Case-control study of dietary etiological factors: The Melbourne colorectal cancer study. Nutr Cancer 1987;9:21-42.
5. Slattery ML, Sorenscn AW, Ford MH: Calcium intake as a mitigating factor in colon cancer. Am J Epidemiol 1988;128:504-514.
6. Whittemore AS, Wu-Williams AH, Lee M, Sau Z, Gallagher RP, Dcng-no J, Lun Z, Xianghui W, Kun C, Jung D, Teh CZ, Chengde L, Vao XJ, Paffenlarger RS, Henderson BE: Diet, physical activity, and colorectal cancer among Chinese in North America. J Natl Cancer Inst 1990;82:915-926.
7. Peters RK, Pike MC, Garabrant D, Mack TM: Diet and colon cancer in Los Angeles county, California. Cancer Causes Contr 1992;3:475-473.
8. Bostic RM, Potter JD, Sellers TA, McKenzie DR, Kushi LH, Folsom AR: Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. Am JEpidemiol 1993;137:1302-1317.
9. Garland C, Shekelle RB, Barret-Connor E, Criqui MH, Rossof AH, Oglcsby P: Dietary vitamin D and calcium and risk of colorcctal cancer: A 19-year prospective study in men. Lancet 1985;i:307-309.
10. Tuyns AJ, Haelterman M, Kaaks R: Colorectal cancer and the intake of nutrients: Oligosaccharides are a risk factor, fats are not. A case control study in Belgium. Nutr Cancer 1987; 10:181-196.
11. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G: A case-control study of diet and rectal cancer in western New York. Am J Epidemiol 1990; 131:612-624.
12. Benito E, Stiggelbout A, Bosch FX, Obrador A, Kaldor J, Mulet M, Munoz N: Nutritional factors in colorectal cancer risk: A case-control study in Majorca. Int J Cancer 199I;49:161-167.
13. Boutron MC, Faivre J, Parteau P, Couillault C, Senesse P, Quipourt V: Calcium, phosphorus, vit D, dairy products and colorectal carcinogenesis: A French case-control study. Br J Cancer 1996;74:145-151.
14. Stemmermann GN, Nomura A, Chyou P-H: The influence of dairy and nondairy calcium on subsite large-bowel cancer risk. Dis Colon Rectum 1990;33:190-194.
15. Kearney J, Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Wing A, Kampman E, Willett WC: Calcium, vitamin D and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 1996; 143:907-917.
16. Bergsma-Kadijk JA, van't Veer P, Kampman E, Burema J: Calcium does not protect against colorectal neoplasia. Epidemiology 1996;7: 590-597.
17. Lipkin M, Newmark HL: Effect of added dietary calcium on colonie epithelial-cell proliferation in subjects at high risk for familial colonie cancer. N Engl J Med 1985;313:1381-1384.
18. Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E: Inhibition of human colonie epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 1986;46:5426-5430.
19. Rozen P, Fireman Z, Fine N, Wax Y, Ron E: Oral calcium suppresses increased rectal epithelial proliferation of persons at risk of colorectal cancer. Gut 1989;30:650-655.
20. Gregoire RC, Stern HS, Yeung KS, Stadier J, Langley S, Furrer R, Bruce WR: Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut 1989;30:376-382.
21. Wargovich MJ, Isbell G, Sharbot M, Winn R, Lanza F, Hochman L, Larsen E, Lynch P, Roubein L, Levin B: Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. Gastroenterology 1992; 103:92-97.
22. Newmark HL, Wargovich MJ, Bruce WR: Colon cancer and dietary fat, phosphate, and calcium: A hypothesis. J Natl Cancer Inst 1984; 72:1323-1325.
23. Appleton GVN, Owen RW, Wheeler EE, Challacombe DN, Williamson RCB: Effect of dietary calcium on the colonie luminal environment. Gut 1991;32:1374-1377.
24. Bostick RM, Potter JD, McKenzie DR, Sellers TA, Kushi LH, Steinmetz KA, Folsom AR: Reduced risk of colon cancer with high intake of vitamin E: The Iowa Women's health study. Cancer Res 1993;53:4230-4237.
25. Wald N, Idle M, Boreham J, et al: Low serum vitamin A and the subsequent risk of cancer. Lancet 1980;ii:813-815.
26. Willett WC, Morris JS, Pressel S, Taylor JO, Folk BF, Stampfer MJ, Schneider K, Curtis GH: Prediagnostic serum selenium and risk of cancer. Lancet I983;ii:130-134.
27. Salonen JT, Salonen R, Lappcttelainen R, Maenpaa PH, Alfthan G, Puska P: Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: Matched case-control analysis of prospective data. Br Med J 1985;290:417-420.
28. Potter JD, McMichael AJ: Diet and cancer of the colon and rectum: A case-control study. J Natl Cancer Inst 1986;76:557-569.
29. Rogers AE, Hemdon BJ, Newbeme PM: Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed on high or low levels of vitamin A. Cancer Res 1973;33: 1003.
30. Newbeme PM, Suphakam V: Preventive role of vitamin A in colon carcinogenesis in rats. Cancer 1977;40:2553-2556.
31. Reddy BS, Hirota N, Katayama S: Effect of dietary sodium ascorbate on 1,2-dimethylhydralazine or methylnitrosourea-induced colon carcinogenesis. Carcinogenesis 1982;3:1097.
32. Cook MG, McNamara P: Effect of dietary vitamin E on dimethylhydrazine-induced colonie tumors in mice. Cancer Res 1980;40:1329-1331.
33. Jacobs MM, Forst CF, Beams FA: Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats. Cancer Res 1981;41:4458-4465.
34. Cahill RJ, O'Sullivan KR, Mathias PM, Beattie S, Hamilton H, O'Morain C: Effects of vitamin antioxidant supplementation on cell kinetics of patients with adenomatous polyps. Gut 1993; 34:963-967.
35. Paganelli GM, Biasco G, Brandi G, Santucci R, Gizzi G, Cianci M, Miglioli M, Barbara L: Effect of vitamin A, C and E supplementation on rectal cell proliferation in patients with colorectal adenomas. J Natl Cancer Inst 1992;84: 47-51.
36. Machlin LJ, Bendrich A: Free radical tissue damage: Protective role of antioxidant nutrients. FASEB J 1987;l:441-445.
37. Roncucci L, Di Donato P, Carati L, Ferrari A, Perini M, Bertoni G, Bedogni G, Paris B, Svanoni F, Girola M, Ponz de Leon M: Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Dis Colon Rectum 1993;36:227-234.
38. Greenberg ER, Baron JA, Tosteson TD, Freeman DH, Beck GJ, Bond JH, Colacchio TA, Coller JA, Frankl HD: A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N EnglJ Med 1994;331:141-147.
39. DeCosse JJ, Miller HH, Lesser ML: Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 1989;81:1290-1297.
40. McKeown-Eyssen GE, Holloway C, Jazmaji V, Bright-See E, Dion P, Bruce WR: A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res 1988;48:4701-4705.
41. McKeown-Eyssen GE, Bright-See E, Bruce RW, Jazmaji V: A randomized trial of a low fat high fibre diet in the recurrence of colorectal polyps. J Clin Epidemiol 1994;47:525-536.
42. Morson EC: The polyp-cancer sequence in the large bowel. Proc R Soc Med 1974;67:451-457.
43. Matek W, Guggenmoos-Holzmann I, Demling L: Follow-up of patients with colorectal adenomas. Endoscopy 1985;17:175-181.
44. Hofstad B, Vatn M, Hoff G, Larsen S, Osnes M: Growth of colorectal polyps. Design of a prospective, randomized, placebo controlled intervention study in patients with colorectal polyps. Eur J Cancer Prevent 1992;l:415-422.
45. Hofstad B, Vatn M, Norheim Andersen S, Rognum T, Huitfeldt HS, Seck-Hanssen A, Larsen S, Osnes M: Growth of colorectal polyps: Recovery and evaluation of unresected polyps for a period of 3 years. Gut 1996;39:449-456.
46. Hofstad B, Vatn M, Larsen S, Huitfeldt HS, Osnes M: In situ measurement of colorectal polyps to compare video and fiberoptic endoscopes. Endoscopy 1994;26:461-465.
47. Hofstad B, Vatn M, Larsen S, Osnes M: Reliability of in situ measurements of colorectal polyps. Scand J Gastroenterol 1992;27:59-64.
48. Hofstad B, Vatn M, Larsen S, Osnes M: Growth of colorectal polyps: Recovery and evaluation of unresected polyps of less than 10 mm, 1 year after detection. Scand J Gastroenterol 1994;29:640-645.
49. Jass JR, Sobin LH: Histological Typing of Intestinal Tumours. WHO International Histological Classification of Tumours. Berlin, Springer, 1989, pp 29-31.
50. Almendingen K, Trygg K, Larsen S, Hofstad B, Vatn MH: Dietary factors and colorectal polyps. A case-control study. Eur J Cancer Prevent 1995;4:239-246.
51. Owen RW, Weisgerber UM, Carr J, Harrison MH: Analysis of calcium-lipid complexes in faeces. Eur J Cancer Prevent 1995;4:247-255.
52. Larsen S, Sandvik L, Osnes M: The sample size in multicentre and stratified-designed trials. Pharm Med 1991;5:97-105.
53. Hoff G, Vatn M: Epidemiology of polyps in the rectum and sigmoid colon. Endoscopie evaluation of size and localization of polyps. Scand J Gastroenterol 1985;20:356-360.
54. Hoff G, Foerster A, Vatn MH, Sauar J, Larsen S: Epidemiology of polyps in the rectum and colon. Recovery and evaluation of unresected polyps 2 years after detection. Scand J Gastroenterol 1986:21:853-862.
55. Kleinbaum D, Kupper L, Muller KE: Applied Regression Analysis and Other Multivariant Methods. Boston, Kent, 1988, vol 2.
56. Giovannucci E, Stampfer MJ, Colditz G, Rimm EB, Willett WC: Relationship of diefto risk of colorectal adenoma in men. J Natl Cancer Inst 1992;84:91-98.
57. Neugut AI, Garbowski GC, Lee WC, Murray T, Nieves JW, Forde KA, Waye JD, FenoglioPreiser D: Dietary risk factors for the incidence and recurrence of colorectal adenomatous polyps. Ann Intern Med 1993;! 18:91-95.
58. Benito E, Cabeza E, Moreno V, Obrador A, Bosch FX: Diet and colorectal adenomas: A case-control study in Majorca. Int J Cancer 1993;55:213-219.
59. Enger SM, Longnecker MP, Chen MJ, Harper JM, Lee ER, Frankl HD, Haile RW: Dietary intake of specific carotenoids and vitamins A, C, and E, and prevalence of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 1996;5:147-153.
60. Macquart-Moulin G, Riboli E, Cornee J, Kaaks R, Berthezene P: Colorectal polyps and diet: A case-control study in Marseilles. Int J Cancer 1987;40:179-188.
61. DeCosse JJ, Adams MB, Kuzuma JF, LoGerfo P, Condon RE: Effect of ascorbic acid on rectal polyps of patients with familial polyposis. Surgery 1975:78:608-612.
62. Bussey HJR, DeCosse JJ, Deschner EE, Eyers AA, Lesser ML, Morson BC, Ritchie SM; Thomson JPS, Wadsworth J: A randomized trial of ascorbic acid in polyposis coli. Cancer 1982;50:1434-1439.
63. Weiberg JWM, Monkelbaan JF, de Vries EGE, Muskiet FAJ, Cats A, Oremus ETHGJ, Boersma-van Ek W, van Risbergen H, van der Meer R, Mulder NH, Kleibeuker JH: Effects of supplemental dietary calcium and qualitative fecal fat excretion in man. Ann Nutr Metab 1994;38: 185-191.
64. van der Meer R, Weiberg JWM, Kuipers F, Kleibeuker JH, Mulder NH, Termont DSML, Vonk RJ, de Vries HT, de Vries EGE: Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate, and bile acids. Gastroenterology 1990;99:1653-1659.
65. Boutron M-C, Faivre J, Quipourt V, Senesse P, Michiels C: Family history of colorcctal tumours and implications for the adenoma-carcinoma sequence: A case control study. Gut 1995;37:830-834.
66. Kleibeuker JH, Weiberg JWM, Mulder NH, van der Meer R, Cats A, Limburg AJ, Kreumer WMT, Hardonk MJ, de Vries EGE: Epithelial cell proliferation in the sigmoid colon of patients with adenomatous polyps increases during oral calcium supplementation. Br J Cancer 1993;67:500-503.
67. Heinonen OP, Huttunen JK, Albanes D: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-1035.
68. The Norwegian Cancer Registry: Cancer in Norway 1992. Oslo, Hellstrom og Nordals boktrykkeri, 1995.
69. Lothe RA, Norheim Andersen S, Hofstad B, Meling GI, Peltomäki P, Heim S, Brogger A, Vatn M, Rognum T, Borresen A-L: Deletion of Ip loci and microsatellite instability in colorectal polyps. Genes Chromosom Cancer 1995;14: 182-188.
70. Kirn H, Yang XL, Rosada C, Hamilton SR, August JT: CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation. Arch Biochem Biophys 1994;310:504-507.
71. Scott N, Bell SM, Sagar P, Blair GE, Dixon MF, Quirke P: p53 expression and K-ras mutation in colorectal adenomas. Gut 1993;34:621-624.