Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4258-4262

  Du, Yanming ^a   Ye, Hong ^a   Guo, Fang ^b   Wang, Lijuan ^b   Gill, Tina ^b   Khan, Noshena ^a   Cuconati, Andrea ^a   Guo, Ju Tao ^b   Block, Timothy M ^a,b   Chang, Jinhong ^b   Xu, Xiaodong ^a  

^a BARUCH S BLUMBERG INSTITUTE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antiviral; BVDV; Metabolic stability; N Alkyldeoxynojirimycin; Oxazolidinone; Sulfonamide; Tacaribe; Urea

Indexed keywords

1 DEOXYNOJIRIMYCIN DERIVATIVE; ANTIVIRUS AGENT;

ANTIVIRAL ACTIVITY; ARENAVIRUS; ARTICLE; BOVINE DIARRHEA VIRUS; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HYDROGEN BOND; IN VITRO STUDY; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; RAT; VIRUS CULTURE;

1-DEOXYNOJIRIMYCIN; ANIMALS; ANTIVIRAL AGENTS; ARENAVIRUSES, NEW WORLD; DIARRHEA VIRUSES, BOVINE VIRAL; DRUG DESIGN; GLUCOSAMINE; HUMANS; MICE; MICROSOMES, LIVER; OXAZOLIDINONES; RATS; SULFONAMIDES; UREA; VIRUS REPLICATION;

BOVINE VIRAL DIARRHEA VIRUS 1; TACARIBE VIRUS;

EID: 84879415298     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.052     Document Type: Article

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