Production of antimicrobial peptides is preserved in aging

Clinical Immunology

Volumn 148, Issue 2, 2013, Pages 198-205

  Castaneda Delgado J E ^a,b   Miranda Castro, N Y ^a   Gonzalez Amaro R ^b   Gonzalez Curiel I ^a   Montoya Rosales, A ^a   Rivas Calderon, B ^a   Rivas Santiago, B ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Aging; Defensin; Immunosenescence; Innate immunity; LL 37

Indexed keywords

BETA DEFENSIN 2; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; MESSENGER RNA;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; INNATE IMMUNITY; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING;; DEFENSIN;; IMMUNOSENESCENCE;; INNATE IMMUNITY; LL-37;;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; RNA, MESSENGER;

EID: 84879389642     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2013.05.015     Document Type: Article

References (39)

1. World Health Organization World Health Statistics 2012 2012, World Health Organization, Geneva.
2. United Nations, Dept.of International Economic and Social Affairs World Population Prospects the 2000 Revision Volume I Comprehensive Tables 2001, United Nations, New York.
3. Weischer M., Bojesen S.E., Cawthon R.M., Freiberg J.J., Tybjaerg-Hansen A., Nordestgaard B.G. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler. Thromb. Vasc. Biol. 2012, 32:822-829.
4. Gokcay F., Arsava E.M., Baykaner T., Vangel M., Garg P., Wu O., Singhal A.B., Furie K.L., Sorensen A.G., Ay H. Age-dependent susceptibility to infarct growth in women. Stroke 2011, 42:947-951.
5. Mukherjee M., Brouilette S., Stevens S., Shetty K.R., Samani N.J. Association of shorter telomeres with coronary artery disease in Indian subjects. Heart 2009, 95:669-673.
6. Vidal J.S., Sigurdsson S., Jonsdottir M.K., Eiriksdottir G., Thorgeirsson G., Kjartansson O., Garcia M.E., van Buchem M.A., Harris T.B., Gudnason V., Launer L.J. Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study. Stroke 2010, 41:891-897.
7. Harte A.L., da Silva N.F., Miller M.A., Cappuccio F.P., Kelly A., O'Hare J.P., Barnett A.H., Al-Daghri N.M., Al-Attas O., Alokail M., Sabico S., Tripathi G., Bellary S., Kumar S., McTernan P.G. Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. Exp. Diabetes Res. 2012, 2012:895185.
8. McElhaney J.E. Influenza vaccine responses in older adults. Ageing Res. Rev. 2011, 10:379-388.
9. Busse P.J., Mathur S.K. Age-related changes in immune function: effect on airway inflammation. J. Allergy Clin.Immunol. 2010, 126:690-699. (quiz 700-691).
10. Birjandi S., Witte P. Why are the elderly so susceptible to pneumonia?. Expert Rev. Respir. Med. 2011, 5:593-595.
11. Pawelec G., Gouttefangeas C. T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?. Aging Clin. Exp. Res. 2006, 18:171-173.
12. Serrano M., Blasco M.A. Cancer and ageing: convergent and divergent mechanisms. Nat. Rev. Mol. Cell Biol. 2007, 8:715-722.
13. Singhal S.K., Roder J.C., Duwe A.K. Suppressor cells in immunosenescence. Fed. Proc. 1978, 37:1245-1252.
14. Pawelec G., Solana R., Remarque E., Mariani E. Impact of aging on innate immunity. J. Leukoc. Biol. 1998, 64:703-712.
15. Weiskopf D., Weinberger B., Grubeck-Loebenstein B. The aging of the immune system. Transpl. Int. 2009, 22:1041-1050.
16. Appay V., Sauce D., Prelog M. The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging (Albany NY) 2010, 2:78-81.
17. Goronzy J.J., Weyand C.M. T cell development and receptor diversity during aging. Curr. Opin. Immunol. 2005, 17:468-475.
18. Effros R.B. Replicative senescence of CD8 T cells: potential effects on cancer immune surveillance and immunotherapy. Cancer Immunol. Immunother. 2004, 53:925-933.
19. Effros R.B., Cai Z., Linton P.J. CD8 T cells and aging. Crit. Rev. Immunol. 2003, 23:45-64.
20. Gon Y., Hashimoto S., Hayashi S., Koura T., Matsumoto K., Horie T. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 1996, 106:120-126.
21. Buffa S., Bulati M., Pellicano M., Dunn-Walters D.K., Wu Y.C., Candore G., Vitello S., Caruso C., Colonna-Romano G. B cell immunosenescence: different features of naive and memory B cells in elderly. Biogerontology 2011, 12:473-483.
22. Bulati M., Buffa S., Candore G., Caruso C., Dunn-Walters D.K., Pellicano M., Wu Y.C., Colonna Romano G. B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans. Ageing Res. Rev. 2011, 10:274-284.
23. Wenisch C., Patruta S., Daxbock F., Krause R., Horl W. Effect of age on human neutrophil function. J. Leukoc. Biol. 2000, 67:40-45.
24. Zissel G., Schlaak M., Muller-Quernheim J. Age-related decrease in accessory cell function of human alveolar macrophages. J. Investig.Med. 1999, 47:51-56.
25. Rivas-Santiago B., Serrano C.J., Enciso-Moreno J.A. Susceptibility to infectious diseases based on antimicrobial peptide production. Infect. Immun. 2009, 77:4690-4695.
26. Bardan A., Nizet V., Gallo R.L. Antimicrobial peptides and the skin. Expert. Opin. Biol. Ther. 2004, 4:543-549.
27. Durr U.H., Sudheendra U.S., Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim. Biophys. Acta 2006, 1758:1408-1425.
28. Bowdish D.M., Davidson D.J., Hancock R.E. Immunomodulatory properties of defensins and cathelicidins. Curr. Top. Microbiol. Immunol. 2006, 306:27-66.
29. Barlow P.G., Li Y., Wilkinson T.S., Bowdish D.M., Lau Y.E., Cosseau C., Haslett C., Simpson A.J., Hancock R.E., Davidson D.J. The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J. Leukoc. Biol. 2006, 80:509-520.
30. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 1984, 28:47-55.
31. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 2008, 3:1101-1108.
32. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
33. Agerberth B., Charo J., Werr J., Olsson B., Idali F., Lindbom L., Kiessling R., Jornvall H., Wigzell H., Gudmundsson G.H. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000, 96:3086-3093.
34. Born J., Uthgenannt D., Dodt C., Nunninghoff D., Ringvolt E., Wagner T., Fehm H.L. Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech. Ageing Dev. 1995, 84:113-126.
35. Fagiolo U., Cossarizza A., Scala E., Fanales-Belasio E., Ortolani C., Cozzi E., Monti D., Franceschi C., Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 1993, 23:2375-2378.
36. Sindermann J., Kruse A., Frercks H.J., Schutz R.M., Kirchner H. Investigations of the lymphokine system in elderly individuals. Mech. Ageing Dev. 1993, 70:149-159.
37. Vo T.K., Godard P., de Saint-Hubert M., Morrhaye G., Bauwens E., Debacq-Chainiaux F., Glupczynski Y., Swine C., Geenen V., Martens H.J., Toussaint O. Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA. Exp. Gerontol. 2010, 45:188-194.
38. Pahl R., Brunke G., Steubesand N., Schubert S., Bottner M., Wedel T., Jurgensen C., Hampe J., Schafer H., Zeissig S., Schreiber S., Rosenstiel P., Reiss K., Arlt A. IL-1beta and ADAM17 are central regulators of beta-defensin expression in Candida esophagitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2011, 300:G547-G553.
39. Alvarez-Rodriguez L., Lopez-Hoyos M., Garcia-Unzueta M., Amado J.A., Cacho P.M., Martinez-Taboada V.M. Age and low levels of circulating vitamin D are associated with impaired innate immune function. J. Leukoc. Biol. 2012, 91:829-838.