Are we ready for a randomized trial of valproic acid in newly diagnosed glioblastoma?

Neuro-Oncology

Volumn 15, Issue 7, 2013, Pages 809-810

  Weller, Michael ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; ETIRACETAM; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; VALPROIC ACID;

DISEASE CONTROL; DNA METHYLATION; DRUG EFFICACY; EDITORIAL; FOLLOW UP; GLIOBLASTOMA; HUMAN; MONOTHERAPY; PHASE 2 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); SEIZURE; SURVIVAL; SURVIVAL TIME;

ANTICONVULSANTS; BRAIN NEOPLASMS; FEMALE; GLIOBLASTOMA; HUMANS; MALE; NEOPLASM RECURRENCE, LOCAL; PIRACETAM; SEIZURES; VALPROIC ACID;

EID: 84879379142     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/not095     Document Type: Editorial

References (6)

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2. Oberndorfer S, Piribauer M, Marosi C, et al. P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy. J Neurooncol 2005; 72: 255-260. (Pubitemid 40867409)
3. Felix FH, Trompieri NM, de Araujo OL, et al. Potential role for valproate in the treatment of high-risk brain tumors of childhood-results from a retrospective observational cohort study. Pediatr Hematol Oncol 2011; 28: 556-570.
4. Barker CA, Bishop AJ, Chang M, et al. Valproic acid use during radiation therapy for glioblastoma associated with improved survival. Int J Radiat Oncol Biol Phys 2013, In press.
5. Weller M, Gorlia T, Cairncross JG, et al. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology 2011; 77: 1156-1164.
6. De Wit-Kerkhof M, Dielemans J, Van Breemen MS, et al. Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. Neuro-Oncology 2013; 15: 961-967.