Implant for augmentation of cerebral blood flow trial 1: A pilot study evaluating the safety and effectiveness of the Ischaemic Stroke System for treatment of acute ischaemic stroke

International Journal of Stroke

Volumn 4, Issue 6, 2009, Pages 480-485

  Khurana, D ^a   Kaul, S ^b   Bornstein, N M ^c  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

ImpACT; ISS; Protocol; Stroke; Treatment

Indexed keywords

ACUTE DISEASE; ADULT; AGED; ARTICLE; BIOASSAY; BRAIN CIRCULATION; BRAIN ISCHEMIA; CLINICAL TRIAL; CONVALESCENCE; CRANIAL NERVE; DRUG EFFECT; ELECTRODE; ELECTROSTIMULATION THERAPY; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PARASYMPATHETIC GANGLION; PHYSIOLOGY; PILOT STUDY; PROSPECTIVE STUDY; STROKE; TREATMENT OUTCOME; VASODILATATION;

ACUTE DISEASE; ADULT; AGED; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CRANIAL NERVES; ELECTRIC STIMULATION THERAPY; ELECTRODES, IMPLANTED; ENDPOINT DETERMINATION; FEMALE; GANGLIA, PARASYMPATHETIC; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; STROKE; TREATMENT OUTCOME; VASODILATION;

EID: 77449091627     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2009.00385.x     Document Type: Article

References (22)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-7.
2. Hacke W, Kaste M, Bluhmki E et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359:1317-29.
3. Smith WS, Sung G, Starkman S et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke. Results of the MERCI Trial. Stroke 2005; 36:1432-40.
4. Hakim AM. The cerebral ischemic penumbra. Can J Neurol Sci 1987; 14:557-9.
5. Fisher M. The ischemic penumbra: identification, evolution and treatment concepts. Cerebrovasc Dis 2004; 17 (Suppl. 1): 1-6.
6. Markus R, Reutens DC, Kazui S et al. Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival. Brain 2004; 127:1427-36.
7. Wei L, Erinjeri JP, Rovainen CM et al. Collateral growth and angiogenesis around cortical stroke. Stroke 2001; 32:2179-84.
8. Brown CE, Murphy TH. Livin' on the edge: imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery. Neuroscientist 2008; 14:139-46.
9. Ayajiki K, Fujioka H, Shinozaki K et al. Effects of capsaicin and nitric oxide synthase inhibitor on increase in cerebral blood flow induced by sensory and parasympathetic nerve stimulation in the rat. J Appl Physiol 2005; 98:1792-8.
10. Seylaz J, Hara H, Pinard E et al. Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat. J Cereb Blood Flow Metab 1988; 8:875-8.
11. Suzuki N, Hardebo JE, Kahrstrom J et al. Selective electrical stimulation of postganglionic cerebrovascular parasympathetic nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat. J Cereb Blood Flow Metab 1990; 10:383-91.
12. Toda N, Tanaka T, Ayajiki K et al. Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys. Neuroscience 2000; 96:393-8.
13. Yarnitsky D, Lorian A, Shalev A et al. Reversal of cerebral vasospasm by sphenopalatine ganglion stimulation in a dog model of subarachnoid hemorrhage. Surg Neurol 2005; 64:5-11.
14. Suzuki N, Hardebo JE, Kahrstrom J et al. Neuropeptide Y co-exists with vasoactive intestinal polypeptide and acetylcholine in parasympathetic cerebrovascular nerves originating in the sphenopalatine, otic, and internal carotid ganglia of the rat. Neuroscience 1990; 36:507-19.
15. Edvinsson L, Elsas T, Suzuki N et al. Origin and co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat. Microsc Res Tech 2001; 53:221-8.
16. Goadsby PJ, Uddman R, Edvinsson L. Cerebral vasodilatation in the cat involves nitric oxide from parasympathetic nerves. Brain Res 1996; 707:110-8.
17. Suzuki N, Hardebo JE. The cerebrovascular parasympathetic innervation. Cerebrovasc Brain Metab Rev 1993; 5:33-46.
18. Koketsu N, Moskowitz MA, Kontos HA et al. Chronic parasympathetic sectioning decreases regional cerebral blood flow during hemorrhagic hypotension and increases infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats. J Cereb Blood Flow Metab 1992; 12:613-20.
19. Kano M, Moskowitz MA, Yokota M. Parasympathetic denervation of rat pial vessels significantly increases infarction volume following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1991; 11:628-37.
20. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke 2007; 38:2779-86.
21. Fiorelli M, Bastianello S, Von Kummer R et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke 1999; 30:2280-4.
22. Available at http://www.ntis.gov