Super-oxidized solution (dermacyn wound care) as adjuvant treatment in the postoperative management of complicated diabetic foot osteomyelitis: Preliminary experience in a specialized department

International Journal of Lower Extremity Wounds

Volumn 12, Issue 2, 2013, Pages 130-137

  Aragón Sánchez, Javier ^a   Lázaro Martínez, Jose Luis ^b   Quintana Marrero, Yurena ^a   Sanz Corbalán, Irene ^b   Hernández Herrero, Maria J ^a   Cabrera Galván, Juan J ^a,c  

^a La Paloma Hospital   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

diabetic foot; diabetic foot infections; osteomyelitis; super oxidized solution

Indexed keywords

ANTIINFECTIVE AGENT; DERMACYN WOUND CARE; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ARTICLE; CLINICAL ARTICLE; DIABETIC FOOT OSTEOMYELITIS; HUMAN; LIMB SALVAGE; OSTEOMYELITIS; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SOFT TISSUE; WOUND HEALING;

DIABETIC FOOT; DIABETIC FOOT INFECTIONS; OSTEOMYELITIS; SUPER-OXIDIZED SOLUTION;

AGED; ANTI-INFECTIVE AGENTS, LOCAL; DEBRIDEMENT; DIABETIC FOOT; DRUG COMBINATIONS; FEMALE; HUMANS; HYPOCHLOROUS ACID; LIMB SALVAGE; MALE; MIDDLE AGED; OSTEOMYELITIS; POSTOPERATIVE CARE; RECURRENCE; SODIUM HYPOCHLORITE; WOUND HEALING;

EID: 84879342680     PISSN: 15347346     EISSN: 15526941     Source Type: Journal    
DOI: 10.1177/1534734613476710     Document Type: Article

References (23)

1. Game F. Management of osteomyelitis of the foot in diabetes mellitus. Nat Rev Endocrinol. 2010 ; 6: 43-47
2. Aragon-Sanchez J. Treatment of diabetic foot osteomyelitis: a surgical critique. Int J Low Extrem Wounds. 2010 ; 9: 37-59
3. Karchmer AW, Gibbons GW. Foot infections in diabetes: evaluation and management. Curr Clin Top Infect Dis. 1994 ; 14: 1-22
4. Ha Van G, Siney H, Danan JP, Sachon C, Grimaldi A. Treatment of osteomyelitis in the diabetic foot. Contribution of conservative surgery. Diabetes Care. 1996 ; 19: 1257-1260
5. Aragon-Sanchez FJ, Cabrera-Galvan JJ, Quintana-Marrero Y, et al. Outcomes of surgical treatment of diabetic foot osteomyelitis: a series of 185 patients with histopathological confirmation of bone involvement. Diabetologia. 2008 ; 51: 1962-1970
6. Frykberg RG, Wittmayer B, Zgonis T. Surgical management of diabetic foot infections and osteomyelitis. Clin Podiatr Med Surg. 2007 ; 24: 469-482
7. Zgonis T, Stapleton JJ, Roukis TS. A stepwise approach to the surgical management of severe diabetic foot infections. Foot Ankle Spec. 2008 ; 1: 46-53
8. Aragon-Sanchez J. Seminar review: a review of the basis of surgical treatment of diabetic foot infections. Int J Low Extrem Wounds. 2011 ; 10: 33-65
9. Aragon-Sanchez J, Lazaro-Martinez JL, Hernandez- Herrero C, et al. Does osteomyelitis in the feet of patients with diabetes really recur after surgical treatment? Natural history of a surgical series. Diabet Med. 2012 ; 29: 813-818
10. Martinez-De Jesus FR, Ramos-De la, Medina A, Remes-Troche JM, et al. Efficacy and safety of neutral pH superoxidised solution in severe diabetic foot infections. Int Wound J. 2007 ; 4: 353-362
11. Piaggesi A, Goretti C, Mazzurco S, et al. A randomized controlled trial to examine the efficacy and safety of a new super-oxidized solution for the management of wide postsurgical lesions of the diabetic foot. Int J Low Extrem Wounds. 2010 ; 9: 10-15
12. Aragon-Sanchez J, Quintana-Marrero Y, Lazaro-Martinez JL, et al. Necrotizing soft-tissue infections in the feet of patients with diabetes: outcome of surgical treatment and factors associated with limb loss and mortality. Int J Low Extrem Wounds. 2009 ; 8: 141-146
13. Eneroth M, Larsson J, Apelqvist J. Deep foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments, and prognosis. J Diabetes Complications. 1999 ; 13: 254-263
14. Aragon-Sanchez J, Lipsky BA, Lazaro-Martinez JL. Diagnosing diabetic foot osteomyelitis: is the combination of probe-to-bone test and plain radiography sufficient for high-risk inpatients?. Diabet Med. 2011 ; 28: 191-194
15. Lineaweaver W, Howard R, Soucy D, et al. Topical antimicrobial toxicity. Arch Surg. 1985 ; 120: 267-270
16. Cooper ML, Laxer JA, Hansbrough JF. The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes. J Trauma. 1991 ; 31: 775-782
17. Hermanns JF, Paquet P, Arrese JE, Pierard-Franchimont C, Pierard GE. The beneficial cytotoxicity of antiseptics. The controversial paradox of cutaneous ulcer treatment. Rev Med Liege. 1999 ; 54: 600-605
18. Duc Q, Breetveld M, Middelkoop E, Scheper RJ, Ulrich MM, Gibbs S. A cytotoxic analysis of antiseptic medication on skin substitutes and autograft. Br J Dermatol. 2007 ; 157: 33-40
19. Aragon-Sanchez J. Evidences and controversies about recurrence of diabetic foot osteomyelitis: a personal view and an illustrated guide for understanding. Int J Low Extrem Wounds. 2012 ; 11: 88-106
20. Garcia-Morales E, Lazaro-Martinez JL, Aragon-Sanchez J, Cecilia-Matilla A, Garcia-Alvarez Y, Beneit-Montesinos JV. Surgical complications associated with primary closure in patients with diabetic foot osteomyelitis. Diabet Foot Ankle. 2012 ; 3 :
21. Aragon-Sanchez J, Lazaro-Martinez JL, Hernandez- Herrero C, et al. Surgical treatment of limb- and life-threatening infections in the feet of patients with diabetes and at least one palpable pedal pulse: successes and lessons learnt. Int J Low Extrem Wounds. 2011 ; 10: 207-213
22. Landsman A, Blume PA, Jordan DA, Vayser D, Gutierrez A. An open-label, three-arm pilot study of the safety and efficacy of topical Microcyn Rx wound care versus oral levofloxacin versus combined therapy for mild diabetic foot infections. J Am Podiatr Med Assoc. 2011 ; 101: 484-496
23. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012 ; 54: e132 - e173