Deep foot infections in patients with diabetes and foot ulcerL An entity with different characteristics, treatments, and prognosis

Journal of Diabetes and its Complications

Volumn 13, Issue 5-6, 1999, Pages 254-263

  Eneroth, Magnus ^a   Larsson, Jan ^a   Apelqvist, Jan ^b  

^a Department of Orthopedics ^*  (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTIBIOTIC AGENT; C REACTIVE PROTEIN; CADEXOMER IODINE; CREATININE; DEXTROPROPOXYPHENE; DIURETIC AGENT; GENTAMICIN; GENTAMICIN BONE CEMENT; HEMOGLOBIN A1C; MESALT; NARCOTIC ANALGESIC AGENT; PARACETAMOL; PETROLATUM; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ABSCESS; ADULT; AGED; AMPUTATION; ANAEROBIC BACTERIUM; ANKLE EDEMA; ARTICLE; BACTERIAL ARTHRITIS; BLOOD PRESSURE; BODY TEMPERATURE; BONE SCINTISCANNING; CELLULITIS; CLINICAL TRIAL; DIABETES MELLITUS; DIABETIC FOOT; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GANGRENE; GLUCOSE BLOOD LEVEL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HISTOLOGY; HOSPITALIZATION; HUMAN; IMMOBILIZATION; INFECTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEITIS; OSTEOMYELITIS; PRIORITY JOURNAL; PROGNOSIS; RADIOGRAPHY; SOFT TISSUE INFECTION; TENDINITIS; TREATMENT OUTCOME; ULTRASOUND;

AGED; ANTI-BACTERIAL AGENTS; ARTHRITIS, INFECTIOUS; DIABETES COMPLICATIONS; DIABETIC FOOT; FEMALE; FOOT ULCER; HOSPITALIZATION; HOSPITALS, UNIVERSITY; HUMANS; INFECTION; MALE; MIDDLE AGED; OSTEOMYELITIS; PROGNOSIS; SWEDEN;

EID: 0033549916     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8727(99)00065-3     Document Type: Article

References (54)

1. Apelqvist J., Castenfors J., Larsson J., Stenström A., Agardh C.-D. Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers. Diabetic Med. 6:1989;525-530.
2. Fylling C.P., Knighton D.R. Amputation in the diabetic population. Incidence, causes, cost, treatment and preventions J Enterostom Ther. 16:1989;247-255.
3. Pecoraro R.E., Reiber G.E., Burgess E.M. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 13:1990;513-521.
4. Larsson J., Agardh C.-D., Apelqvist J., Stenström A. Local signs and symptoms in relation to final amputation in level in diabetic patients. A prospective study of 187 patients with foot ulcers. Acta Orthop Scand. 65:1994;387-393.
5. Larsson J., Apelqvist J., Agardh C.-D., Stenström A. Decreasing incidence of major amputations in diabetic patients - A consequence of a multidisciplinary foot care team approach? Diabetic Med. 12:1995;770-776.
6. LeFrock J.L., Joseph W.S. Bone and soft-tissue infections of the lower extremity in diabetics. Clin Pod Med Surg. 12:1995;87-103.
7. Leichter S.B., Allweiss P., Harley J., Clay J., Kuperstein-Chase J., Sweeney G.J., Kolkin J. Clinical characteristics of diabetic patients with serious pedal infections. Metabolism. 37(suppl):1988;22-24.
8. Borrero E., Rossini Jr M. Bacteriology of 100 consecutive diabetic foot infections and in vitro susceptibility to ampicillin/sulbactam versus cefoxitin. Angiology. April:1992;357-361.
9. Grayson M.L., Gibbons G.W., Habershaw G.M., Freeman D.V., Pomposelli F.B., Rosenblum B.I., Levin E., Karchmer A.W. Use of ampicillin/sulbactam versus imipenem/cilastin in the treatment of limb-threatening foot infections in diabetic patients. Clin Infect Dis. 18:1994;683-693.
10. Edelson G.W., Armstrong D.G., Lavery L.A., Caicco G. The acutely infected diabetic foot is not adequately evaluated in an inpatient setting. Arch Intern Med. 156:1996;2373-2378.
11. Bose K. A surgical approach for the infected diabetic foot. Int Orthop. 3:1979;177-181.
12. Calhoun J.H., Cantrell J., Cobos J., Lacy J., Valdez R.R., Hokanson J., Mader J.T. Treatment of diabetic foot infections. Wagner classification, therapy and outcome Foot Ankle. 9:1988;101-106.
13. Criado E., De Stefano A.A., Keagy B.A., Upchurch G.R. Jr., Johnson G. Jr. The course of severe foot infection in patients with diabetes. Surg Gynecol Obstet. 175:1992;135-140.
14. Chang B.B., Darling R.C. III, Paty P.S.K., Lloyd W.E., Shah D.M., Leather R.P. Expeditious management of ischemic invasive foot infections. Cardiovasc Surg. 4:1996;792-795.
15. Eneroth M., Apelqvist J., Stenström A. Clinical characteristics and outcome in 223 diabetic patients with deep foot infections. A prospective study of 223 patients. Foot Ankle Int. 11:1997;716-722.
16. Wagner F.W. The dysvascular foot. A system for diagnosis and treatment Foot Ankle. 2:1981;63-122.
17. Apelqvist J., Castenfors J., Larsson J., Stenström A., Agardh C.-D. Prognostic value of systolic ankle and toe blood pressure levels in outcome of diabetic foot ulcer. Diabetes Care. 12:1989;373-378.
18. Apelqvist J., Larsson J., Agardh C.-D. Medical risk factors in diabetic patients with foot ulcers and severe peripheral vascular disease and their influence on outcome. J Diabet Complications. 6:1992;167-174.
19. Sentochnik D.E. Deep soft-tissue infections in diabetic patients. Infect Dis Clin N Am. 9:1995;53-64.
20. Colwell J.A., Bingham S.F., Abraira C., Anderson J.S., Kwaan H.C. The cooperative study group. V.A. cooperative study on antiplatelet agents in diabetic patients after amputation for gangrene Horm Metab Res. 15(suppl):1985;60-73.
21. Calhoun J.H., Mader J.T. Osteomyelitis of the diabetic foot I. Frykberg R.G. The High-Risk Foot in Diabetes Mellitus. 1991;213-239 Churchill Livingstone, New York.
22. Newman L.G., Waller J., Palestro C.J., Schwartz M., Klein M.J., Hermann G., Harrington E., Harrington M., Roman S.H., Stagnaro-Green A. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leucocyte scanning with indium 111 oxyquinoline JAMA. 266:1991;1246-1251.
23. Grayson M.L., Gibbons G.W., Balogh K., Levin E., Karchmer A.W. Probing to bone in infected pedal ulcers. A clinical sign of underlying osteomyelitis in diabetic patients. JAMA. 273:1995;721-723.
24. Apelqvist J., Larsson J., Ragnarsson-Tennvall G., Persson U. Topical treatment of diabetic foot ulcers - An economic analysis of different treatment strategies. Diabetic Med. 12:1995;123-128.
25. Gibbons GW, Eliopoulos GM: Infection of the diabetic foot, in Kozak GP, Hoar CS Jr, Rowbotham JL, Wheelock FC Jr, Gibbons GW, Campbell D, (eds), Management of Diabetic Foot Problems. Philadelphia: Saunders, 1984, pp. 97-102.
26. Gleckman R.A., Roth R.M. Diabetic foot infections - Prevention and treatment. West J Med. 142:1985;238-265.
27. Tan J.S., File T.M. Jr. Diagnosis and treatment of diabetic foot infections. Comp Ther. 14:1988;52-62.
28. Joseph W.S. Treatment of lower extremity infections in diabetics. J Am Pod Med Ass. 82:1992;361-370.
29. Grayson M.L. Diabetic foot infections. Antimicrobial therapy. Inf Dis Clin North Am. 9:1995;143-161.
30. Lavery L.A., Armstrong D.G., Harkless L.B. Classifications of diabetic foot wounds. Ostomy Wound Manage. 43:1997;44-48.
31. Armstrong D.G., Lavery L.A., Harkless L.B. Validation of a diabetic wound classification system. The contribution of depth, infection and ischemia to risk of amputation. Diabetes Care. 21:1998;855-859.
32. Gibbons G.W., Habershaw G.M. Diabetic Foot Infections. Anatomy and Surgery. Inf DIs Clin N Am. 9:1995;131-142.
33. Lipsky B.A. Osteomyelitis of the foot in diabetic patients. Clin Inf Dis. 25:1997;1318-1326.
34. Bamberger D.M., Daus G.P., Gerding D.N. Osteomyelitis in the feet of diabetic patients. Am J Med. 83:1987;653-660.
35. Horowitz J.D., Durham J.R., Nease D.B., Lukens M.L., Wright J.G., Smead W.L. Prospective evaluation of magnetic resonance imaging in the management of acute diabetic foot infections. Ann Vasc Surg. 7:1993;44-50.
36. Fletcher E, MacFarlane R, Jeffcoate J: Can foot ulcers be prevented by education? Diabetic Med (suppl 2):41, 1992.
37. Mills J.L., Beckett W.C., Taylor S.M. The diabetic foot. Consequences of delayed treatment and referral South Med J. 84:1991;970-974.
38. Ha Van G., Siney H., Danan J.-P., Sachon C., Grimaldi A. Treatment of osteomyelitis in the diabetic foot. Diabetes Care. 19:1996;1257-1260.
39. Caputo G.M., Joshi N., Weitekamp M.R. Foot infections in patients with diabetes. Am Fam Phys. 56:1997;195-202.
40. LoGerfo F.W., Coffman J.D. Vascular and microvascular disease of the foot in diabetes. N Engl J Med. 311:1984;1615-1619.
41. Larsson J., Apelqvist J., Castenfors J., Agardh C.-D., Stenström A. Distal blood pressure as a predictor for the level of amputation in diabetic patients with foot ulcer. Foot Ankle. 5:1993;247-253.
42. Vitti M.J., Robinson D.V., Hauer-Jensen M., Thompson B.W., Ranval T.J., Barone G., Barnes R.W., Eidit J.F. Wound healing in forefoot amputations. the predictive value of toe pressure Ann Vasc Surg. 8:1994;99-106.
43. West N.J. Systemic antimicrobial treatment of foot infections in diabetic patients. Am J Health Syst Pharm. 52:1995;1199-1207.
44. Sapico F.L., Witte J.L., Canawati H.N., Montomerie J.Z., Bessman A.W. The infected foot of the diabetic patient. Quantitative microbiology and analysis of clinical features Rev Infect Dis. 6(suppl 1):1984;171-176.
45. Wheat L.J., Allen S.D., Henry M., Kernok C.B., Siders J.A., Keuber T., Fineberg N., Norton J. Diabetic infections. Bacteriologic analysis Arch Intern Med. 146:1986;1935-1940.
46. Peterson L.R., Lissack L.M., Canter K., Fasching C.E., Clabots C., Gerding D.N. Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both. Am J Med. 86:1989;801-808.
47. Lavery L.A., Sariaya M., Ashry H., Harkless L.B. Microbiology of osteomyelitis in diabetic foot infections. Foot Ankle Surg. 34:1995;61-64.
48. Gentry L.O. Antibiotic therapy for osteomyelitis. Infect Dis Clin North Am. 4:1990;485-499.
49. Tan J.S., Friedman N.M., Hazelton-Miller C., Flannagan P.J., File T.M. Can aggressive treatment of diabetic foot infections reduce the need for above-ankle amputation? Clin Infect Dis. 23:1996;286-291.
50. Edmonds M.E., Blundell M.P., Morris M.E., Maelor Thomas E., Cotton L.T., Watkins P.J. Improved survival of the diabetic foot. The role of a specialized foot clinic Quart J Med, New Series. 60:1986;763-771.
51. McCabe C.J., Stevenson R.C., Dolan A.M. Evaluation of a diabetic foot screening and protection program. Diabetic Med. 15:1998;80-84.
52. Klamer T.W., Towne J.B., Bandyk D.F., Bonner M.J. The influence of sepsis and ischemia on the natural history of the diabetic foot. Am Surg. 53:1987;490-494.
53. Taylor L.M. Jr., Porter J.M. The clinical course of diabetics who require emergent foot surgery because of infection or ischemia. J Vasc Surg. 6:1987;454-459.
54. Gough A., Clapperton M., Rolando N., Foster A.V.M., Philpott-Howard J., Edmonds M.E. Randomized placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet. 350:1997;855-859.