SLC classification: An update

Clinical Pharmacology and Therapeutics

Volumn 94, Issue 1, 2013, Pages 19-23

  Schlessinger, A ^a   Yee, S W ^b,c   Sali, A ^b,c   Giacomini, K M ^b,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ATORVASTATIN; BACLOFEN; CAPTOPRIL; CARRIER PROTEIN; CEFADROXIL; CEFALEXIN; CIMETIDINE; CYTARABINE; ENALAPRIL; FEXOFENADINE; FLUDARABINE; FLUINDOSTATIN; GABAPENTIN; GEMCITABINE; IPRATROPIUM BROMIDE; LEVODOPA; LIGAND; MELPHALAN; MEMBRANE PROTEIN; MEMBRANE PROTEIN SLC; METFORMIN; METHOTREXATE; NUCLEOSIDE ANALOG; OLMESARTAN; OXALIPLATIN; ROSUVASTATIN; TROSPIUM CHLORIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALACICLOVIR;

AMINO ACID SEQUENCE; CLASSIFICATION; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG TARGETING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; EVOLUTION, MOLECULAR; HUMANS; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MODELS, THEORETICAL; SEQUENCE ALIGNMENT;

EID: 84879339716     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.73     Document Type: Review

References (10)

1. Schlessinger, A. et al. Comparison of human solute carriers. Protein Sci. 19, 412-428 (2010).
2. Hediger, M.A., Romero, M.F., Peng, J-B., Rolfs, A., Takanaga, H. & Bruford, E.A. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Arch. 447, 465-468 (2004).
3. Schlessinger, A. et al. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc. Natl. Acad. Sci. USA 108, 15810-15815 (2011).
4. Geier, E.G. et al. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc. Natl. Acad. Sci. USA 110, 5480-5485 (2013).
5. Gruswitz, F. et al. Function of human Rh based on structure of RhCG at 2.1 Å. Proc. Natl. Acad. Sci. USA 107, 9638-9643 (2010).
6. Sali, A. & Blundell, T.L. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815 (1993).
7. Guan, L. & Kaback, H.R. Lessons from lactose permease. Annu. Rev. Biophys. Biomol. Struct. 35, 67-91 (2006).
8. Pieper, U. et al. Coordinating the impact of structural genomics on the human alpha-helical transmembrane proteome. Nat. Struct. Mol. Biol. 20, 135-138 (2013).
9. Schlessinger, A., Khuri, N., Giacomini, K.M. & Sali, A. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr. Top. Med. Chem. 13, 843-856 (2013).
10. Johnson, Z.L., Cheong, C.G. & Lee, S.Y. Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. Nature 483, 489-493 (2012).