-
1
-
-
12344282783
-
Global burden of hypertension: analysis of worldwide data
-
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, et al. (2005) Global burden of hypertension: analysis of worldwide data. Lancet 365: 17-23.
-
(2005)
Lancet
, vol.365
, pp. 17-23
-
-
Kearney, P.M.1
Whelton, M.2
Reynolds, K.3
Muntner, P.4
Whelton, P.K.5
-
2
-
-
0347135823
-
Therapeutic vaccination for chronic diseases: a new class of drugs in sight
-
Bachmann MF, Dyer MR, (2004) Therapeutic vaccination for chronic diseases: a new class of drugs in sight. Nat Rev Drug Discov 3: 81-88.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 81-88
-
-
Bachmann, M.F.1
Dyer, M.R.2
-
3
-
-
0024599498
-
Structure and function of renin
-
Inagami T (1989) Structure and function of renin. J Hypertens Suppl 7: S3-S8.
-
(1989)
J Hypertens Suppl
, vol.7
-
-
Inagami, T.1
-
4
-
-
77649314549
-
Success and failure of vaccines against renin-angiotensin system components
-
Brown MJ, (2009) Success and failure of vaccines against renin-angiotensin system components. Nat Rev Cardiol 6: 639-647.
-
(2009)
Nat Rev Cardiol
, vol.6
, pp. 639-647
-
-
Brown, M.J.1
-
5
-
-
40049085766
-
The renin-angiotensin system and therapeutic vaccines for hypertension
-
Zhu F, Zhou ZH, Liao YH, (2008) The renin-angiotensin system and therapeutic vaccines for hypertension. Curr Opin Investig Drugs 9: 286-294.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 286-294
-
-
Zhu, F.1
Zhou, Z.H.2
Liao, Y.H.3
-
7
-
-
0023264333
-
Active immunization against renin in normotensive marmoset
-
Michel JB, Guettier C, Philippe M, Galen FX, Corvol P, et al. (1987) Active immunization against renin in normotensive marmoset. Proc Natl Acad Sci U S A 204: 281-288.
-
(1987)
Proc Natl Acad Sci U S A
, vol.204
, pp. 281-288
-
-
Michel, J.B.1
Guettier, C.2
Philippe, M.3
Galen, F.X.4
Corvol, P.5
-
8
-
-
0025294812
-
Physiological and immunopathological consequences of active immunization of spontaneously hypertensive and normotensive rats against murine renin
-
Michel JB, Sayah S, Guettier C, Nussberger J, Philippe M, et al. (1990) Physiological and immunopathological consequences of active immunization of spontaneously hypertensive and normotensive rats against murine renin. Circulation 81: 1899-1910.
-
(1990)
Circulation
, vol.81
, pp. 1899-1910
-
-
Michel, J.B.1
Sayah, S.2
Guettier, C.3
Nussberger, J.4
Philippe, M.5
-
9
-
-
0029054059
-
High Resolution Crystal Structures of Recombinant Human Renin in Complex with Polyhydroxymonoamide Inhibitors
-
Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, et al. (1995) High Resolution Crystal Structures of Recombinant Human Renin in Complex with Polyhydroxymonoamide Inhibitors. J Mol Biol 250: 211-222.
-
(1995)
J Mol Biol
, vol.250
, pp. 211-222
-
-
Tong, L.1
Pav, S.2
Lamarre, D.3
Pilote, L.4
LaPlante, S.5
-
10
-
-
0024438910
-
High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and escription of the rigid body shift in the enzyme
-
Sali A, Veerapandian B, Cooper JB, Foundling SI, Hoover DJ, et al. (1989) High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and escription of the rigid body shift in the enzyme. EMBO J 8: 2179-2188.
-
(1989)
EMBO J
, vol.8
, pp. 2179-2188
-
-
Sali, A.1
Veerapandian, B.2
Cooper, J.B.3
Foundling, S.I.4
Hoover, D.J.5
-
11
-
-
0023224255
-
Production and characterization of human renin antibodies with region-oriented synthetic peptide
-
Bouhnik J, Galen FX, Menard J, Corvol P, Seyer R, et al. (1987) Production and characterization of human renin antibodies with region-oriented synthetic peptide. J Biol Chem 262: 2913-2918.
-
(1987)
J Biol Chem
, vol.262
, pp. 2913-2918
-
-
Bouhnik, J.1
Galen, F.X.2
Menard, J.3
Corvol, P.4
Seyer, R.5
-
12
-
-
0030842457
-
Design of peptide and polypeptide vaccines
-
Ben-Yedidia T, Arnon R, (1997) Design of peptide and polypeptide vaccines. Curr Opin Biotechnol 8: 442-448.
-
(1997)
Curr Opin Biotechnol
, vol.8
, pp. 442-448
-
-
Ben-Yedidia, T.1
Arnon, R.2
-
13
-
-
33751099863
-
Prediction of residues in discontinuous B-cell epitopes using protein 3D structures
-
Haste Andersen P, Nielsen M, Lund O, (2006) Prediction of residues in discontinuous B-cell epitopes using protein 3D structures. Protein Sci 15: 2558-2567.
-
(2006)
Protein Sci
, vol.15
, pp. 2558-2567
-
-
Haste Andersen, P.1
Nielsen, M.2
Lund, O.3
-
14
-
-
58149395884
-
Epitopic peptides with low similarity to the host proteome: towards biological therapies without side effects
-
Kanduc D, (2009) Epitopic peptides with low similarity to the host proteome: towards biological therapies without side effects. Expert Opin Biol Ther 9: 45-53.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 45-53
-
-
Kanduc, D.1
-
15
-
-
18144371672
-
Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10
-
Lucchese A, Mittelman A, Lin MS, Kanduc D, Sinha AA, (2004) Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. J Transl Med 2: 43.
-
(2004)
J Transl Med
, vol.2
, pp. 43
-
-
Lucchese, A.1
Mittelman, A.2
Lin, M.S.3
Kanduc, D.4
Sinha, A.A.5
-
16
-
-
59249102885
-
Proteome-based epitopic peptide scanning along PSA
-
Stufano A, Kanduc D, (2009) Proteome-based epitopic peptide scanning along PSA. Exp Mol Pathol 86: 36-40.
-
(2009)
Exp Mol Pathol
, vol.86
, pp. 36-40
-
-
Stufano, A.1
Kanduc, D.2
-
17
-
-
0022474952
-
Study of the antigenic determinants of human renin
-
Evin G, Carlson WD, Handschumacher M, Novotný J, Matsueda GR, et al. (1986) Study of the antigenic determinants of human renin. Hypertension 8: II72-II77.
-
(1986)
Hypertension
, vol.8
-
-
Evin, G.1
Carlson, W.D.2
Handschumacher, M.3
Novotný, J.4
Matsueda, G.R.5
-
18
-
-
0023858012
-
Characterization of five epitopes of human renin from a computer model
-
Evin G, Galen FX, Carlson WD, Handschumacher M, Novotný J, et al. (1988) Characterization of five epitopes of human renin from a computer model. Biochemistry 27: 156-164.
-
(1988)
Biochemistry
, vol.27
, pp. 156-164
-
-
Evin, G.1
Galen, F.X.2
Carlson, W.D.3
Handschumacher, M.4
Novotný, J.5
-
19
-
-
0023551802
-
Production and characterization of human renin antibodies prepared with synthetic immunogens
-
Galen FX, Evin G, Carelli C, Bouhnik J, Michel JB, et al. (1987) Production and characterization of human renin antibodies prepared with synthetic immunogens. J Hypertens Suppl 5: S11-S14.
-
(1987)
J Hypertens Suppl
, vol.5
-
-
Galen, F.X.1
Evin, G.2
Carelli, C.3
Bouhnik, J.4
Michel, J.B.5
-
20
-
-
0015441086
-
Renin in Rats with Spontaneous Hypertension
-
Sen S, Smeby RR, Bumpus FM, (1972) Renin in Rats with Spontaneous Hypertension. Circ Res 31: 876-880.
-
(1972)
Circ Res
, vol.31
, pp. 876-880
-
-
Sen, S.1
Smeby, R.R.2
Bumpus, F.M.3
-
21
-
-
0018490487
-
Serial renin-angiotensin studies in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Transition from normal- to high-renin status during the established phase of spontaneous hypertension
-
Bagby SP, McDonald WJ, Mass RD, (1979) Serial renin-angiotensin studies in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Transition from normal- to high-renin status during the established phase of spontaneous hypertension. Hypertension 1: 347-354.
-
(1979)
Hypertension
, vol.1
, pp. 347-354
-
-
Bagby, S.P.1
McDonald, W.J.2
Mass, R.D.3
-
22
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer I, Boada Rovira M, Sánchez Guerra ML, Rey MJ, Costa-Jussá F, (2004) Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol 14: 11-20.
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Sánchez Guerra, M.L.3
Rey, M.J.4
Costa-Jussá, F.5
-
23
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
-
Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, et al. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9: 448-452.
-
(2003)
Nat Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
-
24
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, et al. (2003) Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61: 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
-
25
-
-
62649118757
-
Therapeutic renin-angiotensin vaccines for the treatment of hypertension
-
Feng Zhu, Yuhua Liao, (2008) Therapeutic renin-angiotensin vaccines for the treatment of hypertension. Drugs of the Future 33: 1-9.
-
(2008)
Drugs of the Future
, vol.33
, pp. 1-9
-
-
Feng, Z.1
Yuhua, L.2
-
26
-
-
4043179763
-
Renin-angiotensin vaccine: old story, new project 'efficacy versus safety
-
Michel JB, (2004) Renin-angiotensin vaccine: old story, new project 'efficacy versus safety'. Clin Sci (Lond) 107: 145-147.
-
(2004)
Clin Sci (Lond)
, vol.107
, pp. 145-147
-
-
Michel, J.B.1
-
27
-
-
34548685847
-
Novel Abeta immunogens: is shorter better?
-
Lemere CA, Maier M, Peng Y, Jiang L, Seabrook TJ, (2007) Novel Abeta immunogens: is shorter better? Curr Alzheimer Res 4: 427-436.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 427-436
-
-
Lemere, C.A.1
Maier, M.2
Peng, Y.3
Jiang, L.4
Seabrook, T.J.5
-
28
-
-
39749098706
-
Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide
-
Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, et al. (2008) Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide. Hypertension 51: 682-688.
-
(2008)
Hypertension
, vol.51
, pp. 682-688
-
-
Feldt, S.1
Batenburg, W.W.2
Mazak, I.3
Maschke, U.4
Wellner, M.5
-
29
-
-
44849107992
-
Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells
-
Batenburg WW, de Bruin RJ, van Gool JM, Müller DN, Bader M, et al. (2008) Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol 28: 1151-1157.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1151-1157
-
-
Batenburg, W.W.1
de Bruin, R.J.2
van Gool, J.M.3
Müller, D.N.4
Bader, M.5
-
30
-
-
77951499583
-
Prorenin, Renin, and Their Receptor Moving Targets
-
Reudelhuber TL, (2010) Prorenin, Renin, and Their Receptor Moving Targets. Hypertension 55: 1071-1074.
-
(2010)
Hypertension
, vol.55
, pp. 1071-1074
-
-
Reudelhuber, T.L.1
-
31
-
-
80051471498
-
Angiotensin (1-7) Induces Mas Receptor Internalization
-
Gironacci MM, Adamo HP, Corradi G, Santos RA, Ortiz P, et al. (2011) Angiotensin (1-7) Induces Mas Receptor Internalization. Hypertension 58: 176-181.
-
(2011)
Hypertension
, vol.58
, pp. 176-181
-
-
Gironacci, M.M.1
Adamo, H.P.2
Corradi, G.3
Santos, R.A.4
Ortiz, P.5
-
32
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen NC, et al. (2003) Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 308: 698-705.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
Grütter, M.G.4
Cohen, N.C.5
-
33
-
-
84869492851
-
Cardiorenal end points in a trial of aliskiren for type 2 diabetes
-
Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, et al. (2012) Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 367: 2204-2213.
-
(2012)
N Engl J Med
, vol.367
, pp. 2204-2213
-
-
Parving, H.H.1
Brenner, B.M.2
McMurray, J.J.3
de Zeeuw, D.4
Haffner, S.M.5
|