The regulatory impacts of Morus Alba leaf extract on some enzymes involved in glucose metabolism pathways in diabetic rat liver

Clinical Laboratory

Volumn 59, Issue 5-6, 2013, Pages 497-504

  Nazari, Mahmood ^a   Hajizadeh, Mohammad Reza ^b   Mahmoodi, Mehdi ^a   Mirzaei, Mohammad Reza ^a   Hassanshahi, Gholamhossein ^a  

^a RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

FPK 1 enzymes; Glucokinase; Hexokinase; Morus Alba (mulberry) leaf; Type 1 diabetes

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ANTIDIABETIC AGENT; GLUCOKINASE; GLUCOSE; HEXOKINASE; INSULIN; LIVER ENZYME; MESSENGER RNA; MULBERRY EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN BLOOD LEVEL; MALE; MORUS ALBA; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CARBOHYDRATE METABOLISM; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; INSULIN; LIVER; MALE; MORUS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLANT EXTRACTS; PLANT LEAVES; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR;

MORUS (ANGIOSPERM); MORUS ALBA; RATTUS; RATTUS NORVEGICUS;

EID: 84879330081     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: 10.7754/Clin.Lab.2012.120611     Document Type: Article

References (28)

1. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. Journal of the American College of Nutrition 2001;20(4):327-36. Epub 2001/08/17.
2. Yaghini N, Mahmoodi M, Hassanshahi G, Asadikaram G, Arababadi MK, Rezaeian M, et al. Genetic variation of IL-12B (+1188 region) is associated with its decreased circulating levels and susceptibility to Type 2 diabetes. Biomarkers in Medicine 2012;6(1):89-95. Epub 2012/02/03.
3. Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 2009;301(20):2129-40. Epub 2009/05/28.
4. Yaghmoor SS, Khoja SM. Effect of Cinnamon on Plasma Glucose Concentration and the Regulation of 6-phosphofructo-1-kinase Activity from the Liver and Small Intestine of Streptozotocin Induced Diabetic Rats. Journal of Biological Sciences 2010 (10):8:761-6.
5. Lemhadri A, Eddouks M, Sulpice T, Burcelin R. Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice. American Journal of Pharmacology and Toxicology 2007:106-10.
6. Ma X, Iwanaka N, Masuda S, et al. Morus alba leaf extract stimulates 5′-AMP-activated protein kinase in isolated rat skeletal muscle. Journal of Ethnopharmacology 2009;122(1):54-9. Epub 2008/12/23.
7. Oh YC, Kang OH, Choi JG, et al. Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells. The American Journal of Chinese Medicine 2009;37(6):1203-14. Epub 2009/11/26.
8. Mudra M, Ercan-Fang N, Zhong L, Furne J, Levitt M. influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30(5):1272-4. Epub 2007/02/17.
9. Miyahara C, Miyazawa M, Satoh S, Sakai A, Mizusaki S. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. Journal of Nutritional Science and Vitaminology 2004;50(3):161-4. Epub 2004/09/25.
10. Chen F, Nakashima N, Kimura I, Kimura M. [Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice]. Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan 1995;115(6):476-82. Epub 1995/06/01.
11. Davidson AL, Arion WJ. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Archives of Biochemistry and Biophysics 1987;253(1):156-67. Epub 1987/02/15.
12. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53. Epub 2004/04/28.
13. Kim SY, Gao JJ, Lee WC, Ryu KS, Lee KR, Kim YC. Antioxidative flavonoids from the leaves of Morus alba. Archives of Pharmacal Research 1999;22(1):81-5. Epub 1999/03/11.
14. Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kukongviriyapan U, Nakmareong S, Itharat A. Mulberry leaf extract restores arterial pressure in streptozotocin-induced chronic diabetic rats. Nutrition Research 2009;29:602-8. Epub 2009/06/17.
15. Sharma R, Sharma A, Shono T, et al. Mulberry moracins: scavengers of UV stress-generated free radicals. Bioscience, Biotechnology, and Biochemistry 2001;65(6):1402-5. Epub 2001/07/27.
16. Lee CY, Sim SM, Cheng HM. Phenylacetic acids were detected in the plasma and urine of rats administered with low-dose mulberry leaf extract. Nutrition Research (New York, NY) 2008;28(8):555-63. Epub 2008/12/17.
17. Hassimotto NM, Genovese MI, Lajolo FM. Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. Nutrition Research (New York, NY) 2008;28(3):198-207. Epub 2008/12/17.
18. Bastar I, Seckin S, Uysal M, Aykac-Toker G. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Research communications in molecular pathology and pharmacology. 1998;102(3):265-72. Epub 1999/05/26.
19. Borchgrevink CF, Andersen R, Hall J, Hatteland K, Ursin-Holm A. "Premarin" as a Haemostatic Agent: Failure to Demonstrate Any Laboratory or Clinical Effect. British Medical Journal 1960;2(5213):1645-7. Epub 1960/12/03.
20. Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure (London, England: 1993) 2004;12(3):429-38. Epub 2004/03/16.
21. Vestergaard H, Bjorbaek C, Hansen T, Larsen FS, Granner DK, Pedersen O. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. The Journal of Clinical Investigation 1995;96(6):2639-45. Epub 1995/12/01.
22. Abrantes JL, Alves CM, Costa J, et al. Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1). Biochimica et biophysica acta 2012;1822(8):1198-206. Epub 2012/05/01.
23. Postic C, Dentin R, Girard J. Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes & metabolism 2004;30(5):398-408. Epub 2005/01/27.
24. Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006;77(7-8):568-73. Epub 2006/10/31.
25. Oku T, Yamada M, Nakamura M, Sadamori N, Nakamura S. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. The British Journal of Nutrition 2006;95(5):933-8. Epub 2006/04/14.
26. Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U. Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods for Human Nutrition (Dordrecht, Netherlands) 2009;64(2):116-21. Epub 2009/05/13.
27. Gulubova R, Boiadzhiev T. [Morphological changes in the endocrine pancreas of the rabbit after the administration of a Morus alba extract]. Morfologichni promeni v endokrinniia pankreas na zaek sled prilagane na ekstrakt ot Morus alba. Eksperimentalna Meditsina i Morfologiia 1975;14(3):166-71. Epub 1975/01/01.
28. Singab AN, El-Beshbishy HA, Yonekawa M, Nomura T, Fukai T. Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. Journal of Ethnopharmacology 2005;100(3):333-8. Epub 2005/05/12.