Synthesis and pharmacological evaluation of some novel thebaine derivatives: N-(tetrazol-1H-5-yl)-6,14-endoethenotetrahydrothebaine incorporating the 1,3,4-oxadiazole or the 1,3,4-thiadiazole moiety

Archiv der Pharmazie

Volumn 346, Issue 6, 2013, Pages 455-462

  Yavuz, Serkan ^a   Ünal, Yusuf ^a   Pamir, Özgür ^a   Yilmazer, Demet ^b   Kurtipek, Ömer ^a   Kavutçu, Mustafa ^a   Arslan, Mustafa ^a   Ark, Mustafa ^a   Yildirir, Yilmaz ^a  

^a GAZI UNIVERSITY   (Turkey)

^b Ankara yildirim Beyazit Research and training Hospital   (Turkey)

Author keywords

Analgesic activity; Oxadiazole; Tetrazole; Thebaine; Thiadiazole

Indexed keywords

ANALGESIC AGENT; MORPHINE; THEBAINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HISTOPATHOLOGY; LD 50; LIVER INJURY; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REACTION TIME; TAIL FLICK TEST; THIN LAYER CHROMATOGRAPHY;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MORPHINE; OXADIAZOLES; PAIN; RATS; RATS, WISTAR; THEBAINE; THIADIAZOLES;

EID: 84879310372     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201200451     Document Type: Article

References (16)

1. H. Schidhammer, Prog. Med. Chem. 1998, 35, 83-132.
2. G. R. Lenz, S. M. Evans, D. E. Walters, A. J. Hopfinger, Opiates, Academic Press, Orlando, London 1986.
3. J. W. Lewis, Drug Alcohol Depend. 1985, 14, 363-372.
4. M. Odabasoglu, S. Yavuz, O. Pamir, Y. Yildirir, O. Büyükgü ngör, Acta Crystalogr. Section E 2009, E65, o864.
5. J. W. Lewis, M. J. Readhead, A. C. B. Smith, J. Med. Chem. 1973, 16 (1), 9-12.
6. J. W. Lewis, S. M. Husbands, J. Med. Chem. 2004, 43, 139-141.
7. J. W. Lewis, S. M. Husbands, Curr. Pharm. Design. 2004, 10 (7), 717-732.
8. S. Yavuz, Y. Yildirir, Helv. Chim. Acta. 2010, 93, 2406-2418.
9. J. W. Lewis, K. W. Bentley, A. Cowan, Ann. Rev. Pharrnacol. 1971, 11, 241-270.
10. R. D. Bruce, Fundam. Appl. Tox. 1985, 5, 151-157.
11. K. W. Bentley, D. G. Hardy, A. C. B. Smith, J. Chem. Soc. C 1969, 17, 2235-2236.
12. S. Yavuz, Y. Yildirir, Phosphorus Sulfur Silicon 2012, 187, 1303-1311.
13. Y. Yildirir, Ö. Pamir, S. Yavuz, A. Dişli, J. Het. Chem. DOI: 10.1002/jhet.1074
14. E. A. Boyle, F. R. Mangan, R. E. Markwell, S. A. Smith, M. J. Thomson, R. W. Ward, P. A. Wyman, J. Med. Chem. 1986, 29, 894-898.
15. L. G. Luna, Manual of Histological Staining Methods of the Armed Forces Institute of Pathology, 3rd ed., Mc-Graw-Hill, New York 1968, p. 567.
16. W. H. Habig, M. J. Pabst, W. B. Jakoby, J. Biol. Chem. 1974, 249, 7130-7139.