Distinguishing benign and life-threatening pneumatosis intestinalis in patients with cancer by CT imaging features

American Journal of Roentgenology

Volumn 200, Issue 5, 2013, Pages 1042-1047

  Lee, Kyungmouk Steve ^a   Hwang, Sinchun ^a   Rúa, Sandra M Hurtado ^b   Janjigian, Yelena Y ^a   Gollub, Marc J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cancer; Colon; CT; Gastrointestinal radiology; Pneumatosis intestinalis

Indexed keywords

ANTINEOPLASTIC AGENT; STEROID;

ABDOMINAL RADIOGRAPHY; ADOLESCENT; ADULT; AGE; AGED; ARTICLE; ASCITES; BOWEL DILATATION; BOWEL WALL THICKENING; CANCER CLASSIFICATION; CANCER PATIENT; CHILD; CLINICAL FEATURE; COHORT ANALYSIS; COLON; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; DRUG USE; ENTEROPATHY; FEMALE; FOLLOW UP; GENDER; HUMAN; LIFE THREAT; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MESENTERIC STRANDING; MESENTERY DISEASE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PNEUMATOSIS INTESTINALIS; PNEUMOPERITONEUM; PORTOMESENTERIC VENOUS AIR; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SCHOOL CHILD; COMPUTER ASSISTED TOMOGRAPHY; METHODOLOGY; MIDDLE AGED; NEOPLASM; RADIOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; THORAX RADIOGRAPHY; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PNEUMATOSIS CYSTOIDES INTESTINALIS; RADIOGRAPHY, THORACIC; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

MLCS; MLOWN;

EID: 84879303867     PISSN: 0361803X     EISSN: 15463141     Source Type: Journal    
DOI: 10.2214/AJR.12.8942     Document Type: Article

References (18)

1. Galandiuk S, Fazio VW. Pneumatosis cystoides intestinalis: a review of the literature. Dis Colon Rectum 1986; 29:358-363
2. Keene JG. Pneumatosis cystoides intestinalis and intramural intestinal gas. J Emerg Med 1989; 7:645-650
3. Knechtle SJ, Davidoff AM, Rice RP. Pneumatosis intestinalis: surgical management and clinical outcome. Ann Surg 1990; 212:160-165
4. Heng Y, Schuffler MD, Haggitt RC, Rohrmann CA. Pneumatosis intestinalis: a review. Am J Gastroenterol 1995; 90:1747-1758
5. Pear BL. Pneumatosis intestinalis: a review. Radiology 1998; 207:13-19
6. Koss LG. Abdominal gas cysts (pneumatosis cystoides intestinorum hominis): an analysis with a report of a case and a critical review of the literature. AMA Arch Pathol 1952; 53:523-549
7. Pieterse AS, Leong AS, Rowland R. The mucosal changes and pathogenesis of pneumatosis cystoides intestinalis. Hum Pathol 1985; 16:683-688
8. Ho LM, Paulson EK, Thompson WM. Pneumatosis intestinalis in the adult: benign to life-threatening causes. AJR 2007; 188:1604-1613
9. Olson DE, Kim YW, Ying J, Donnelly LF. CT predictors for differentiating benign and clinically worrisome pneumatosis intestinalis in children beyond the neonatal period. Radiology 2009; 253:513-519
10. Borns PF, Johnston TA. Indolent pneumatosis of the bowel wall associated with immune suppressive therapy. Ann Radiol (Paris) 1973; 16:163-166
11. Jaffe N, Carlson DH, Vawter GE. Pneumatosis cystoides intestinalis in acute leukemia. Cancer 1972; 30:239-243
12. Smith BH, Welter LH. Pneumatosis intestinalis. Am J Clin Pathol 1967; 48:455-465
13. Asmis TR, Chung KY, Teitcher JB, Kelsen DP, Shah MA. Pneumatosis intestinalis: a variant of bevacizumab related perforation possibly associated with chemotherapy related GI toxicity. Invest New Drugs 2008; 26:95-96
14. Coriat R, Ropert S, Mir O, et al. Pneumatosis intestinalis associated with treatment of cancer patients with the vascular growth factor receptor tyrosine kinase inhibitors sorafenib and sunitinib. Invest New Drugs 2011; 29:1090-1093
15. McCarville MB, Whittle SB, Goodin GS, et al. Clinical and CT features of benign pneumatosis intestinalis in pediatric hematopoietic stem cell transplant and oncology patients. Pediatr Radiol 2008; 38:1074-1083
16. R Development Core Team. R: a language and environment for statistical computing. R Project website. www.R-project.org. Published 2008. Accessed January 11, 2013
17. Wiesner W, Mortelé KJ, Glickman JN, Ji H, Ros PR. Pneumatosis intestinalis and portomesenteric venous gas in intestinal ischemia: correlation of CT findings with severity of ischemia and clinical outcome. AJR 2001; 177:1319-1323
18. Kernagis LY, Levine MS, Jacobs JE. Pneumatosis intestinalis in patients with ischemia: correlation of CT findings with viability of the bowel. AJR 2003; 180:733-736