Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies: Frameshift peptides for treating MSI+ blood cancers

European Journal of Cancer

Volumn 49, Issue 11, 2013, Pages 2587-2595

  Maletzki, Claudia ^a   Schmidt, Fabian ^a   Dirks, Wilhelm G ^b   Schmitt, Michael ^c   Linnebacher, Michael ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Frameshift antigens; Haematological malignancies; Microsatellite instability

Indexed keywords

CASPASE 5; CHROMIUM; GAMMA INTERFERON; HLA A2 ANTIGEN; PROTEIN MSH3; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ARTICLE; CD8+ T LYMPHOCYTE; ENZYME LINKED IMMUNOSPOT ASSAY; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; LEUKEMIA; LYMPHOMA; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; FRAMESHIFT MUTATION; HEMATOLOGIC NEOPLASMS; HUMANS; MICROSATELLITE INSTABILITY; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84879296590     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.02.035     Document Type: Article

References (40)

1. Y. Ionov, M.A. Peinado, S. Malkhosyan, D. Shibata, and M. Perucho Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature 363 1993 558 561
2. G. Mao, F. Yuan, and K. Absher Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression Cell Res 18 2008 281 289
3. L.M. Rimsza, K.J. Kopecky, and J. Ruschulte Microsatellite instability is not a defining genetic feature of acute myeloid leukemogenesis in adults: results of a retrospective study of 132 patients and review of the literature Leukemia 14 2000 1044 1051
4. G. Bedi, W. Westra, H. Farzadegan, P.M. Pitha, and D. Sidransky Microsatellite instability in primary neoplasms from HIV + patients Nat Med 1 1995 65 68
5. A. Duval, M. Raphael, and C. Brennetot The mutator pathway is a feature of immunodeficiency-related lymphomas Proc Natl Acad Sci U S A 101 2004 5002 5007
6. J. Offman, G. Opelz, and B. Doehler Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation Blood 104 2004 822 828
7. S.M. Woerner, A. Benner, and C. Sutter Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes Oncogene 22 2003 2226 2235
8. A. Duval, M. Reperant, and R. Hamelin Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers Oncogene 21 2002 8062 8086
9. M. Linnebacher, J. Gebert, and W. Rudy Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens Int J Cancer 93 2001 6 11
10. I. Saeterdal, J. Bjørheim, and K. Lislerud Frameshift-mutation- derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer Proc Natl Acad Sci U S A 98 2001 13255 13260
11. E. Ripberger, M. Linnebacher, and Y. Schwitalle Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene J Clin Immunol 23 2003 415 423
12. Y. Schwitalle, M. Linnebacher, and E. Ripberger Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells Cancer Immunol 4 2004 14
13. Y. Schwitalle, M. Kloor, and S. Eiermann Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers Gastroenterology 134 2008 988 997
14. M. Linnebacher, A. Wienck, I. Boeck, and E. Klar Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO) J Biomed Biotechnol 2010 2010 841451
15. J. Greiner, L. Bullinger, and B.A. Guinn Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells Clin Cancer Res 14 2008 7161 7166
16. S. Anguille, Van Tendeloo, and ZN. Berneman Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia Leukemia 26 2012 2186 2196
17. B. de Rijke, A. van Horssen-Zoetbrood, and J.M. Beekman A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia J Clin Invest 115 2005 3506 3516
18. Y. Garbe, C. Maletzki, and M. Linnebacher An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes PLoS One 6 2011 e26517
19. P. Findeisen, M. Kloor, and S. Merx T25 repeat in the 3′ untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer Cancer Res 65 2005 8072 8078
20. P. Taverna, L. Liu, A. Hanson, A. Monks, and A. Gerson Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen Cancer Chemother Pharmacol 46 2000 507 516
21. E. Matheson, and A. Hall Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia Carcinogenesis 24 2003 31 38
22. N. Adachi, S. So, and S. Iiizumi The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination DNA Cell Biol 25 2006 19 24
23. L. Gu, B. Cline-Brown, F. Zhang, L. Qiu, and G.M. Li Mismatch repair deficiency in hematological malignancies with microsatellite instability Oncogene 21 2002 5758 5764
24. J. Bocsi, and A. Zalatnai Establishment and long-term xenografting of human pancreatic carcinomas in immunosuppressed mice: changes and stability in morphology, DNA ploidy and proliferation activity J Cancer Res Clin Oncol 125 1999 9 19
25. C. Lengauer, K.W. Kinzler, and B. Vogelstein Genetic instabilities in human cancers Nature 396 1998 643 649
26. M.E. Arana, and T.A. Kunkel Mutator phenotypes due to DNA replication infidelity Semin Cancer Biol 20 2010 304 311
27. A. Tinelli, V. Mezzolla, and G. Leo Microsatellite instability (MSI) as genomic markers in endometrial cancer: toward scientific evidences Mini Rev Med Chem 10 2010 1356 1365
28. H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer Cancer Res 53 1993 5087 5089
29. M. Leite, G. Corso, and S. Sousa Seruca. MSI phenotype and MMR alterations in familial and sporadic gastric cancer Int J Cancer 128 2011 1606 1613
30. C.R. Boland, and A. Goel Microsatellite instability in colorectal cancer Gastroenterology 138 2010 2073 2087
31. H. Sill, J. Goldman, and N. Cross Rarity of microsatellite alterations in acute myeloid leukaemia Br J Cancer 74 1996 255 257
32. L. Sanz-Vaqué, D. Colomer, and F. Bosch Microsatellite instability analysis in typical and progressed mantle cell lymphoma and B-cell chronic lymphocytic leukemia Haematologica 86 2001 181 186
33. D. Rund, S. Krichevsky, and S. Bar-Cohen Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 96 adult patients Leukemia 19 2005 1919 1928
34. I. Casorelli, J. Offman, and L. Mele Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome DNA Repair (Amst) 2 2003 547 559
35. P. Faber, P. Fisch, and M. Waterhouse Frequent genomic alterations in epithelium measured by microsatellite instability following allogeneic hematopoietic cell transplantation in humans Blood 107 2006 3389 3396
36. M. Themeli, L. Petrikkos, and M. Waterhouse Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia Leukemia 24 2010 536 543
37. R. Barnetson, R. Eckstein, B. Robinson, and M. Schnitzler There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability Genes Chromosomes Cancer 38 2003 149 156
38. K. Inoue, T. Kohno, S. Takakura, Y. Hayashi, H. Mizoguchi, and J. Yokota Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines. Leuk Res 2000;24:255-62. Erratum in Leuk Res 24 2000 255 262 Erratum in: Leuk Res 2001;25:275-8
39. A. Banerjea, S. Bustin, and S. Dorudi The immunogenicity of colorectal cancers with high degree microsatellite instability World J Surg Oncol 3 2005 26
40. M. Reuschenbach, M. Kloor, and M. Morak Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome Fam Cancer 9 2010 173 179