Quantitative histological assessment of xenobiotic-induced liver enzyme induction and pituitary-thyroid axis stimulation in rats using whole-slide automated image analysis

Journal of Histochemistry and Cytochemistry

Volumn 61, Issue 5, 2013, Pages 362-371

  Garrido, Rosario ^a   Zabka, Tanja S ^b   Tao, Jianhua ^b   Fielden, Mark ^c   Fretland, Adrian ^a   Albassam, Mudher ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b GENENTECH INC   (United States)

^c AMGEN INC   (United States)

Author keywords

Digital slide quantitation; Image analysis; Immunohistochemistry; Preclinical evaluation

Indexed keywords

CYTOCHROME P450; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME ANTIBODY; GLUCURONOSYLTRANSFERASE; HORMONE ANTIBODY; LIVER ENZYME; MESSENGER RNA; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RO 2910; THYROTROPIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GOITER; HISTOPATHOLOGY; HORMONE DETERMINATION; HYPOPHYSIS; HYPOPHYSIS PARS DISTALIS; HYPOPHYSIS THYROID SYSTEM; IMAGE ANALYSIS; IMMUNOREACTIVITY; LIVER HYPERTROPHY; MALE; MITOSIS RATE; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION; THYROTROPIN BLOOD LEVEL; ALGORITHM; ANIMAL; AUTOMATION; BLOOD; DRUG EFFECT; ENZYMOLOGY; FEASIBILITY STUDY; HISTOLOGY; HYPERTROPHY; IMAGE PROCESSING; LIVER; METABOLISM; METHODOLOGY; PATHOLOGY; THYROID GLAND; WISTAR FURTH RAT;

RATTUS;

ALGORITHMS; ANIMALS; AUTOMATION; ENZYME INDUCTION; FEASIBILITY STUDIES; FEMALE; HISTOLOGICAL TECHNIQUES; HYPERTROPHY; IMAGE PROCESSING, COMPUTER-ASSISTED; LIVER; MALE; PITUITARY GLAND; RATS; RATS, INBRED WF; THYROID GLAND; THYROTROPIN; XENOBIOTICS;

MLCS; MLOWN;

EID: 84879288629     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155413482926     Document Type: Article

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