Lack of correlation between the size of HIV proviral DNA reservoir and the level of immune activation in HIV-infected patients with a sustained undetectable HIV viral load for 10 years

Journal of Clinical Virology

Volumn 57, Issue 4, 2013, Pages 351-355

  Poizot Martin, Isabelle ^a   Faucher, Olivia ^a   Obry Roguet, Véronique ^a   Nicolino Brunet, Corinne ^a   Ronot Bregigeon, Sylvie ^a   Dignat George, Françoise ^a   Tamalet, Catherine ^b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

HIV DNA proviral; HIV reservoir; HIV 1; Immune activation markers

Indexed keywords

NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS DNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CROSS-SECTIONAL STUDY; DNA CONTENT; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; T LYMPHOCYTE SUBPOPULATION; VIRUS LOAD;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CROSS-SECTIONAL STUDIES; DNA, VIRAL; FEMALE; HIV; HIV INFECTIONS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RNA, VIRAL; T-LYMPHOCYTE SUBSETS; VIRAL LOAD;

EID: 84879260273     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2013.04.007     Document Type: Article

References (22)

1. Battegay M., Nuesch R., Hirschel B., Kaufman G.R. Immunological recovery and antiretroviral therapy in HIV-1 infection. Lancet Infect Dis 2006, 6:280-287.
2. Kaufmann G.R., Perrin L., Pantaleo G., Opravil M., Furrer H., Telenti A., et al. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study. Arch Intern Med 2003, 163:2187-2195.
3. Moore R.D., Keruly J.C. CD4 cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis 2007, 44:441-446.
4. 3 or greater. J Acquir Immune Defic Syndr 2007, 45:183-192.
5. Mocroft A., Philips A.N., Gatell J., Ledergerber B., Fisher M., Clumeck N., et al. Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study. Lancet 2007, 370:407-413.
6. Le Moing V., Thiébaud R., Chêne G., Sobel A., Massip P., Collin F., et al. Long term evolution of CD4 count in patients with a plasma HIV RNA persistently<500 copies/ml during treatment with antiretroviral drugs. HIV Med 2007, 8:156-163.
7. Wong J.K., Hezareh M., Gunthard H.F., Havlir D.V., Ignacio C.C., Spina C.A., et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997, 278:1295-1300.
8. Poles M.A., Boscardin W.J., Elliott J., Taing P., Fuerst M.M., McGowan I., et al. Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individuals. J Acquir Immune Defic Syndr 2006, 43:65-68.
9. Chun T.W., Nickle D.C., Justement J.S., Meyers J.H., Roby G., Hallahan C.W., et al. Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J Infect Dis 2008, 197:714-720.
10. Steel A., John L., Shamji M.H., Henderson D.C., Gotch F.M., Gazzard B.G., et al. CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and its poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Med 2008, 9:118-125.
11. Benito J.M., Lopez M., Lozano S., Martinez P., Gonzàlez-Lahoz J., Soriano V. CD38 expression on CD8+ T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy. AIDS Res Hum Retroviruses 2004, 20:227-233.
12. Hunt P.W., Martin J.N., Sinclair E., Bredt B., Hagos E., Lampiris H., et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003, 187:1534-1543.
13. Massanella M., Negredo E., Pérez-Alvarez N., Puig J., Ruiz-Hernàndez P., Bofill M., et al. CD4-T cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS 2010, 24:959-968.
14. Plaeger S.F., Collins B.S., Musib R., Deeks S.G., Read S., Embry A. Immune activation in the pathogenesis of treated chronic HIV Disease: a workshop summary. AIDS Res Hum Retroviruses 2012, 28:469-477.
15. Poizot-Martin I. HIV infection: negative effects of viral replication during treatment. Antibiotiques 2008, 10:73-80.
16. Pugliese P., Cuzin L., Cabié A., Poizot-Martin I., Allavena C., Duvivier C., et al. A large French prospective cohort of HIV-infected patients: the Nadis Cohort. HIV Med 2009, 10:504-511.
17. Burgard M., Boufassa F., Viard J.P., Garrigue I., Ruffault A., Izopet J., et al. ANRS AC11 working group factors influencing peripheral blood mononuclear cell-associated HIV-1 DNA level after long-term suppressive antiretroviral therapy in 236 patients. AIDS 2009, 23:2165-2171.
18. Chun T.W., Murray D., Justement J.S., Hallahan C.W., Moir S., Kovacs C., et al. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis 2011, 204:135-138.
19. Chun T.W., Justement J.S., Pandya P., Hallahan C.W., McLaughlin M., Liu S., et al. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy. J Infect Dis 2002, 185:1672-1676.
20. Ostrowski S.R., Katzenstein T.L., Pedersen B.K., Gerstoft J., Ullum H. Residual viraemia in HIV-1-infected patients with plasma viral load
21. Steel A., Cox A.E., Shamji M.H., John L., Nelson M., Henderson D.C., et al. HIV-1 viral replication below 50 copies/ml in patients on antiretroviral therapy is not associated with CD8+ T-cell activation. Antivir Ther 2007, 12:971-975.
22. Avettand Fènoël V., Bouteloup V., Mélard A., Fagard C., Chaix M.L., Leclercq P., et al. members of the ETOILE study Higher HIV-1 DNA associated with lower gains in CD4 cell count among patients with advanced therapeutic failure receiving optimized treatment (ANRS 123-ETOILE). J Antimicrob Chemother 2010, 65:2212-2214.