Identification of differential protein binding affinities in an atropisomeric pharmaceutical compound by noncovalent mass spectrometry, equilibrium dialysis, and nuclear magnetic resonance

Analytical Chemistry

Volumn 85, Issue 12, 2013, Pages 5958-5964

  Maple, Hannah J ^a,b   Garlish, Rachel A ^b   Whitcombe, Ian ^b   Hold, Adam ^c   Prosser, Christine E ^b   Ford, Daniel ^b   MacKenzie, Harry ^b   Crosby, John ^a   Porter, John ^b   Taylor, Richard J ^b   Crump, Matthew P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c LC MS Consulting Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC PROTEIN; DIFFERENTIAL BINDING; EQUILIBRIUM DIALYSIS; EQUILIBRIUM MIXTURES; INTERCONVERTING ISOMERS; PHARMACEUTICAL COMPOUNDS; PROTEIN BINDING AFFINITY; SATURATION TRANSFER DIFFERENCE NMR;

BINDING ENERGY; BIOCHEMISTRY; DIALYSIS; ISOMERS; MASS SPECTROMETRY;

MIXTURES;

DRUG; PROTEIN BCL 2; PROTEIN BCL X;

ARTICLE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROTEIN BINDING;

BCL-X PROTEIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84879231613     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac400760p     Document Type: Article

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