Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases

American Journal of Surgical Pathology

Volumn 32, Issue 3, 2008, Pages 420-425

  Schmitt, Anja M ^a,b   Riniker, Florian ^a   Anlauf, Martin ^c   Schmid, Sonja ^a   Soltermann, Alex ^a   Moch, Holger ^a   Heitz, Philipp U ^a   Klöppel, Günther ^c   Komminoth, Paul ^b   Perren, Aurel ^a,d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b TRIEMLI HOSPITAL   (Switzerland)

^c UNIVERSITY OF KIEL   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Carcinoid; Cdx2; Intestinal endocrine tumor; Isl1; Metastasis of unknown primary; Pancreatic endocrine tumor; TTF1

Indexed keywords

ANTIBODY; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR ISL1; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOCRINE TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; PANCREAS TUMOR; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

DNA-BINDING PROTEINS; GASTROINTESTINAL NEOPLASMS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NEOPLASM METASTASIS; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 40849114945     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318158a397     Document Type: Article

References (18)

1. Abate-Shen C. Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer. 2002;2:777-785.
2. Ahlgren U, Pfaff SL, Jessell TM, et al. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature. 1997;385:257-260.
3. Barbareschi M, Roldo C, Zamboni G, et al. CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors. Am J Surg Pathol. 2004;28:1169-1176.
4. Cai YC, Banner B, Glickman J, et al. Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Hum Pathol. 2001;32:1087-1093.
5. Dong J, Asa SL, Drucker DJ. Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. Mol Endocrinol. 1991;5:1633-1641.
6. Erickson LA, Papouchado B, Dimashkieh H, et al. Cdx2 as a marker for neuroendocrine tumors of unknown primary sites. Endocr Pathol. 2004;15:247-252.
7. Ericson J, Thor S, Edlund T, et al. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science. 1992;256:1555-1560.
8. Jaffee IM, Rahmani M, Singhal MG, et al. Expression of the intestinal transcription factor CDX2 in carcinoid tumors is a marker of midgut origin. Arch Pathol Lab Med. 2006;130:1522-1526.
9. Jensen J. Gene regulatory factors in pancreatic development. Dev Dyn. 2004;229:176-200.
10. Karlsson O, Thor S, Norberg T, et al. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 1990;344:879-882.
11. La Rosa S, Rigoli E, Uccella S, et al. CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. Virchows Arch. 2004;445:248-254.
12. Mazziotta RM, Borczuk AC, Powell CA, et al. CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfall. Appl Immunohistochem Mol Morphol. 2005;13:55-60.
13. Moch H, Schraml P, Bubendorf L, et al. Identification of prognostic parameters for renal cell carcinoma by cDNA arrays and cell chips. Verh Dtsch Ges Pathol. 1999;83:225-232.
14. Ph.U. Heitz, Komminoth P, Perren A, et al. Histological Classification of Tumours of the Endocrine Pancreas. Lyon: IARC Press; 2004.
15. Saqi A, Alexis D, Remotti F, et al. Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids. Am J Clin Pathol. 2005;123:394-404.
16. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol. 1996;16:619-625.
17. Thor S, Ericson J, Brannstrom T, et al. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron. 1991;7:881-889.
18. Travis WD, Rush W, Flieder DB, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol. 1998;22:934-944.