Anxiolytic action of pterostilbene: Involvement of hippocampal ERK phosphorylation

Planta Medica

Volumn 79, Issue 9, 2013, Pages 723-730

  Al Rahim, Md ^a,c   Rimando, Agnes M ^b   Silistreli, Kalpten ^a,d   El Alfy, Abir T ^a,e  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b NATURAL PRODUCTS UTILIZATION RESEARCH UNIT   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MINISTRY OF HEALTH   (Turkey)

^e CHICAGO STATE UNIVERSITY   (United States)

Author keywords

anxiolytic activity; elevated plus maze; ERK phosphorylation; hippocampus; pterostilbene

Indexed keywords

ANXIOLYTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PTEROSTILBENE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOWN REGULATION; HIPPOCAMPUS; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; PLASMA; PROTEIN PHOSPHORYLATION; TRANQUILIZING ACTIVITY; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOTOR ACTIVITY; PHOSPHORYLATION; STILBENES;

ANIMALIA; MUS;

EID: 84879223370     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328553     Document Type: Article

References (33)

1. Nutt D. J., Ballenger J C., Sheehan D., Wittchen H. U. Generalized anxiety disorder: Comorbidity, comparative biology and treatment. Int J Neuropsychopharmacol: 2002; 5 315 325
2. Ohayon M. M. Anxiety disorders: prevalence, comorbidity and outcomes. J Psychiatr Res: 2006; 40 475 476
3. Bandelow B., Zohar J., Hollander E., Kasper S., Möller H. J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J Biol Psychiatry: 2008; 9 248 312
4. Baldwin D. S., Anderson I. M., Nutt D. J., Bandelow B., Bond A., Davidson J. R., den Boer J. A., Fineberg N. A., Knapp M., Scott J., Wittchen H. U. Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol: 2005; 19 567 596
5. Chong J., Poutaraud A., Hugueney P. Metabolism and roles of stilbenes in plants. Plant Sci: 2009; 177 143 155
6. Agnihotri G., Rana A. C., Sharma R. An update on pharmacological properties of resveratrol. Int Res J Pharm: 2012; 3 56 60
7. Rimando A. M., Kalt W., Magee J. B., Dewey J., Ballington J. R. Resveratrol, pterostilbene, and piceatannol in Vaccinium berries. J Agric Food Chem: 2004; 52 4713 4719
8. Remsberg C. M., Yáñez J. A., Ohgami Y., Vega-Villa K. R., Rimando A. M., Davies N. M. Pharmacometrics of pterostilbene: Pre-Clinical pharmacokinetics and metabolism, anti-cancer, anti-inflammatory, anti-oxidant, and analgesic activity. Phytother Res: 2008; 22 169 179
9. Rimando A. M., Rangaswamy N., Feller D. E., Yokoyama W. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem: 2005; 53 3403 3407
10. Paul S., DeCastro A. J., Lee H. J., Smolarek A. K., So J. Y., Simi B., Wang C. X., Zhou R., Rimando A. M., Suh N. Dietary intake of pterostilbene, a constituent of blueberries, inhibits the b-catenin/p 65 downstream signaling pathway and colon carcinogenesis in rats. Carcinogenesis: 2012; 31 1272 1278
11. Joseph J. A., Fisher D. R., Cheng V., Rimando A. M., Shukitt-Hale B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem: 2008; 56 10544 10551
12. Youn J., Lee J-S, Na H-K, Kundu J. K., Surh Y-J. Resveratrol and piceatannol inhibit iNOS expression and NF- κ B activation in dextran sulfate sodium-induced mouse colitis. Nutr Cancer: 2009; 61 847 854
13. Muria M., Handler N., Erker T., Pleban K., Ecker G., Saiko P., Szekeres T., Jaeger W. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem: 2004; 12 5571 5578
14. Paul S., Rimando A. M., Lee H. J., Ji Y., Reddy B. S., Suh N. Anti-inflammatory action of pterostilbene is mediated through the p 38 mitogen-activated protein kinase pathway in colon cancer cells. Cancer Prev Res: 2009; 2 650 657
15. Hetman M., Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem: 2004; 271 2050 2055
16. Gerrits M., Westenbroek C., Koch T., Grootkarzijn A., Ter Horst G. J. Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration. Neuroscience: 2006; 142 1293 1302
17. Paul S., Olausson P., Venkitaramani D. V., Ruchkina I., Moran T. D., Tronson N., Mills E., Hakim S., Salter M. W., Taylor J. R., Lombroso P. J. The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala. Biol Psychiatry: 2007; 61 1049 1061
18. Tronson N. C., Schrick C., Fischer A., Sananbenesi F., Pagès G., Pouysségur J., Radulovic J. Regulatory mechanisms of fear extinction and depression-like behavior. Neuropsychopharmacology: 2008; 33 1570 1583
19. Ailing F., Fan L., Li S., Manji S. Role of extracellular signal-regulated kinase signal transduction pathway in anxiety. J Psychiatr Res: 2008; 43 55 63
20. Barros D., Amaral O. B., Izquierdo I., Geracitano L., Raseira M. CB, Henriques A. T., Ramirez M. R. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacol Biochem Behav: 2006; 84 229 234
21. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav: 1996; 54 21 30
22. Al Rahim M., Nakajima A., Saigusa D., Tetsu N., Maruyama Y., Shibuya M., Yamakoshi H., Tomioka Y., Iwabuchi Y., Ohizumi Y., Yamakuni T. 4′-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry: 2009; 48 7713 7721
23. Al Rahim M., Thatipamula S., Hossain M. A. Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury. Neurobiol Dis: 2013; 50 59 68
24. Manna S. S., Umathe S. N. Transient receptor potential vanilloid 1 channels modulate the anxiolytic effect of diazepam. Brain Res: 2011; 1425 75 82
25. Tronson N. C., Schrick C., Fischer A., Sananbenesi F., Pagès G., Pouysségur J., Radulovic J. Regulatory mechanisms of fear extinction and depression-like behavior. Neuropsychopharmacology: 2008; 33 1570 1583
26. Martínez M. C., Fernandez S. P., Loscalzo L. M., Wasowski C., Paladini A. C., Marder M., Medina J. H., Viola H. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol Biochem Behav: 2009; 92 291 296
27. Vignes M., Maurice T., Lanté F., Nedjar M., Thethi K., Guiramand J., Récasens M. Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG). Brain Res: 2006; 1110 102 115
28. Sah J. F., Balasubramanian S., Eckert R. L., Rorke E. A. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem: 2004; 279 12755 12762
29. Kalluri H. S., Ticku M. K. Role of GABA (A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase. Eur J Pharmacol: 2002; 451 51 54
30. Kim D. H., Kim J. M., Park S. J., Lee S., Shin C. Y., Cheong J. H., Ryu J. H. Hippocampal extracellular signal-regulated kinase signaling has a role in passive avoidance memory retrieval induced by GABAA receptor modulation in mice. Neuropsychopharmacology: 2012; 37 1234 1244
31. Calabrese E. J., Mattson M. P., Calabrese V. Resveratrol commonly displays hormesis: Occurrence and biomedical significance. Hum Exp Toxicol: 2010; 29 980 1015
32. Son T. G., Camandola S., Mattson M. P. Hormetic Dietary Phytochemicals. Neuromol Med: 2008; 10 236 246
33. Olton D. S., Papas B. C. Spatial memory and hippocampal function. Neuropsychologia: 1979; 17 669 682