Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training

European Journal of Applied Physiology

Volumn 113, Issue 7, 2013, Pages 1783-1792

  Liu, Te Chih ^a   Lin, Che Hung ^a   Huang, Chih Yang ^b,c   Ivy, John L ^d   Kuo, Chia Hua ^a,b  

^a UNIVERSITY OF TAIPEI   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Free testosterone; HIIT; Lactate; LH; Luteinizing hormone

Indexed keywords

LUTEINIZING HORMONE; PRASTERONE; TESTOSTERONE;

AGE; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; MALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; OXYGEN CONSUMPTION; RANDOMIZED CONTROLLED TRIAL; SEDENTARY LIFESTYLE; YOUNG ADULT;

ADMINISTRATION, ORAL; AGE FACTORS; CROSS-OVER STUDIES; DEHYDROEPIANDROSTERONE; DOUBLE-BLIND METHOD; EXERCISE; HUMANS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; SEDENTARY LIFESTYLE; TESTOSTERONE; YOUNG ADULT;

EID: 84879223214     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-013-2607-x     Document Type: Article

References (41)

1. Ahtiainen JP, Hulmi JJ, Kraemer WJ, Lehti M, Nyman K, Selanne H, Alen M, Pakarinen A, Komulainen J, Kovanen V, Mero AA, Hakkinen K (2009) Heavy resistance exercise training and skeletal muscle androgen receptor expression in younger and older men. Steroids 76:183-192
2. Almeida OP, Yeap BB, Hankey GJ, Jamrozik K, Flicker L (2008) Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry 65:283-289
3. Arlt W, Haas J, Callies F, Reincke M, Hubler D, Oettel M, Ernst M, Schulte HM, Allolio B (1999) Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 84:2170-2176
4. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM (2010) Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 95:2536-2559
5. Cumming DC, Vickovic MM, Wall SR, Fluker MR, Belcastro AN (1985) The effect of acute exercise on pulsatile release of luteinizing hormone in women runners. Am J Obstet Gynecol 153:482-485
6. Cumming DC, Wall SR, Quinney HA, Belcastro AN (1987) Decrease in serum testosterone levels with maximal intensity swimming exercise in trained male and female swimmers. Endocr Res 13:31-41
7. Gant N, Hutchinson H, Siiteri P, MacDonald P (1971) Study of the metabolic clearance rate of dehydroisoandrosterone sulfate in pregnancy. Am J Obstet Gynecol 111:555-563
8. Gibala MJ, McGee SL (2008) Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? Exerc Sport Sci Rev 36:58-63
9. Hakkinen K, Pakarinen A, Alen M, Kauhanen H, Komi PV (1988) Neuromuscular and hormonal adaptations in athletes to strength training in two years. J Appl Physiol 65:2406-2412
10. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86:724-731
11. Hayes FJ, Seminara SB, DeCruz S, Boepple PA, Crowley WF (2000) Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. J Clin Endocrinol Metab 85:3027-3035
12. Herbst KL, Bhasin S (2004) Testosterone action on skeletal muscle. Curr Opin Clin Nutr Metab Care 7:271-277
13. Huang Y, Chen M, Fang C, Lee W, Yang S, Kuo C (2006) A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate- an oldest-old female study. Int J Med Sci 3:141-147
14. Hyde Z, Flicker L, Almeida OP, Hankey GJ, McCaul KA, Chubb SA, Yeap BB (2010) Low free testosterone predicts frailty in older men: the health in men study. J Clin Endocrinol Metab 95:3165-3172
15. Jensen J, Oftebro H, Breigan B, Johnsson A, Ohlin K, Meen HD, Strømme SB, Dahl HA (1991) Comparison of changes in testosterone concentrations after strength and endurance exercise in well trained men. Eur J Appl Physiol 63:467-471
16. Kraemer WJ, Gordon SE, Fleck SJ, Marchitelli LJ, Mello R, Dziados JE, Friedl K, Harman E, Maresh C, Fry AC (1991) Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med 12:228-235
17. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM (2006) Androgenic responses to resistance exercise: effects of feeding and l-carnitine. Med Sci Sports Exerc 38:1288-1296
18. Kroboth PD, Salek FS, Pittenger AL, Fabian TJ, Frye RF (1999) DHEA and DHEA-S: a review. J Clin Pharmacol 39:327-348
19. Labrie F (2010) DHEA, important source of sex steroids in men and even more in women. Prog Brain Res 182:97-148
20. Lamberts SWJ, van den Beld AW, van der Lely AJ (1997) The endocrinology of aging. Science 278:419-424
21. Lane A, Duke J, Hackney A (2010) Influence of dietary carbohydrate intake on the free testosterone: cortisol ratio responses to short-term intensive exercise training. Eur J Appl Physiol 108:1125-1131
22. Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C (2004) Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. J Clin Endocrinol Metab 89:1174-1180
23. Lee WC, Chen SM, Wu MC, Hou CW, Lai YC, Laio YH, Lin CH, Kuo CH (2006) The role of dehydroepiandrosterone levels on physiologic acclimatization to chronic mountaineering activity. High Alt Med Biol 7:228-236
24. Liao YH, Liao KF, Kao CL, Chen CY, Huang CY, Chang WS, Ivy JL, Jeffrey R, Bernard JR, Lee SD, Kuo CH (2013) Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage. Eur J Appl Physiol 113(1):99-107
25. Lin H, Wang SW, Wang RY, Wang PS (2001) Stimulatory effect of lactate on testosterone production by rat Leydig cells. J Cell Biochem 83:147-154
26. MacConnie SE, Barkan A, Lampman RM, Schork MA, Beitins IZ (1986) Decreased hypothalamic gonadotropin-releasing hormone secretion in male marathon runners. New Engl J Med 315:411-417
27. McMurray R, Eubank T, Hackney A (1995) Nocturnal hormonal responses to resistance exercise. Eur J Appl Physiol 72:121-126
28. Moffat SD, Zonderman AB, Metter EJ, Kawas C, Blackman MR, Harman SM, Resnick SM (2004) Free testosterone and risk for Alzheimer disease in older men. Neurology 62:188-193
29. Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SSC (1998) The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol 49:421-432
30. Nindl BC, Kraemer WJ, Deaver DR, Peters JL, Marx JO, Heckman JT, Loomis GA (2001) LH secretion and testosterone concentrations are blunted after resistance exercise in men. J Appl Physiol 91:1251-1258
31. Schmid P, Pusch HH, Wolf W, Pilger E, Pessenhofer H, Schwaberger G, Pristautz H, Purstner P (1982) Serum FSH, LH, and testosterone in humans after physical exercise. Int J Sports Med 03:84-89
32. Schnorr JA, Bray MJ, Veldhuis JD (2001) Aromatization mediates testosterone's short-term feedback restraint of 24-Hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men. J Clin Endocrinol Metab 86:2600-2606
33. Tremblay MS, Copeland JL, Van Helder W (2004) Effect of training status and exercise mode on endogenous steroid hormones in men. J Appl Physiol 96:531-539
34. Tsai YM, Chou SW, Lin YC, Hou CW, Hung KC, Kung HW, Lin TW, Chen SM, Lin CY, Kuo CH (2006) Effect of resistance exercise on dehydroepiandrosterone sulfate concentrations during a 72-h recovery: relation to glucose tolerance and insulin response. Life Sci 79:1281-1286
35. van den Beld AW, de Jong FH, Grobbee DE, Pols HAP, Lamberts SWJ (2000) Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
36. Wehr E, Pilz S, Boehm BO, März W, Grammer T, Obermayer-Pietsch B (2011) Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 13:482-488
37. Williams M, Dawood T, Ling S, Dai A, Lew R, Myles K, Funder J, Sudhir K, Komesaroff P (2004) Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 89:4708-4715
38. Yamada Y, Sekihara H, Omura M, Yanase T, Takayanagi R, Mune T, Yasuda K, Ishizuka T, Ueshiba H, Miyachi Y, Iwasaki T, Nakajima A, Nawata H (2007) Changes in serum sex hormone profiles after short-term low-dose administration of dehydroepiandrosterone (DHEA) to young and elderly persons. Endocr J 54:153-162
39. Yang SC, Chen CY, Liao YH, Lin FC, Lee WC, Cho YM, Chen MT, Chou CH, Kuo CH (2005) Interactive effect of an acute bout of resistance exercise and dehydroepiandrosterone administration on glucose tolerance and serum lipids in middle-aged women. Chin J Physiol 48:23-29
40. Yeap BB, Almeida OP, Hyde Z, Norman PE, Chubb SAP, Jamrozik K, Flicker L (2007) In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study. Eur J Endocrinol 156:585-594
41. Yeap BB, Hyde Z, Norman PE, Chubb SAP, Golledge J (2010) Associations of total testosterone, sex hormone-binding globulin, calculated free testosterone, and luteinizing hormone with prevalence of abdominal aortic aneurysm in older men. J Clin Endocrinol Metab 95:1123-1130