Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia

International Journal of Antimicrobial Agents

Volumn 42, Issue 1, 2013, Pages 27-35

  Saxena, Anil K ^a   Roy, Kuldeep K ^a   Singh, Supriya ^a   Vishnoi, S P ^a   Kumar, Anil ^a   Kashyap, Vivek Kr ^a   Kremer, Laurent ^b   Srivastava, Ranjana ^a   Srivastava, Brahm S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Hypoxia; Inhibitor; Latent TB; Lipase; Mycobacterium; Rv3097c

Indexed keywords

ESTERASE INHIBITOR; RECOMBINANT ENZYME; RECOMBINANT LIPASE Y; SMALL MOLECULE INHIBITOR; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HYPOXIA; IN VITRO STUDY; LATENT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; VERO CELL;

ANAEROBIOSIS; ANIMALS; ANTI-BACTERIAL AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; ENZYME INHIBITORS; LIPASE; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; VERO CELLS;

EID: 84879218731     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.03.007     Document Type: Article

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