HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional

Immunology

Volumn 139, Issue 3, 2013, Pages 342-351

  Bere, Alfred ^a   Denny, Lynette ^b   Naicker, Prinola ^a   Burgers, Wendy A ^a   Passmore, Jo Ann S ^a,c  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

Author keywords

Cervical cytobrushes; HIV; Mucosal; Polyfunctional; T cell expansion

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL EXPANSION; CELL FUNCTION; CLINICAL ARTICLE; CYTOKINE RESPONSE; FEMALE; FEMALE GENITAL SYSTEM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; PRIORITY JOURNAL; T LYMPHOCYTE; UTERINE CERVIX; VIRUS LOAD;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CERVIX UTERI; CHEMOKINE CCL4; CHRONIC DISEASE; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA; VIRAL LOAD;

EID: 84879216924     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12084     Document Type: Article

References (37)

1. + T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 1999; 189:991-8.
2. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994; 68:6103-10.
3. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994; 68:4650-5.
4. Goulder PJ, Phillips RE, Colbert RA et al. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat Med 1997; 3:212-7.
5. Price DA, Goulder PJ, Klenerman P, Sewell AK, Easterbrook PJ, Troop M, Bangham CR, Phillips RE. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A 1997; 94:1890-5.
6. + T cells. Blood 2006; 107:4781-9.
7. + T cell responses. J Exp Med 2007; 204:1405-16.
8. Darrah PA, Patel DT, De Luca PM et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 2007; 13:843-50.
9. Duvall MG, Precopio ML, Ambrozak DA et al. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol 2008; 38:350-63.
10. + CD4 T cell responses is associated with nonprogression in HIV-1 infection. J Immunol 2002; 169:6376-85.
11. + T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med 2007; 204:2473-85.
12. Brenchley JM, Knox KS, Asher AI et al. High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage. Mucosal Immunol 2008; 1:49-58.
13. + T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection. J Virol 2007; 81:5460-71.
14. + T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol 2008; 1:475-88.
15. Ferre AL, Hunt PW, Critchfield JW et al. Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control. Blood 2009; 113:3978-89.
16. Gumbi PP, Nkwanyana NN, Bere A, et al. Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection. J Virol 2008; 82:8529-36.
17. + lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J Immunol 2000; 164:1602-11.
18. Shacklett BL, Beadle TJ, Pacheco PA et al. Characterization of HIV-1-specific cytotoxic T lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects. Virology 2000; 270:317-2.
19. + T-lymphocyte responses in blood and mucosa during chronic infection. J Virol 2005; 79:4289-97.
20. Shacklett BL, Yang O, Hausner MA et al. Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods 2003; 279:17-31.
21. Nkwanyana NN, Gumbi PP, Roberts L et al. Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract. Immunology 2009; 128:e746-57.
22. Liebenberg LJ, Gamieldien H, Mkhize NN, Jaumdally SZ, Gumbi PP, Denny L, Passmore JA. Stability and transport of cervical cytobrushes for isolation of mononuclear cells from the female genital tract. J Immunol Methods 2011; 367:47-55.
23. Bere A, Denny L, Hanekom W, Burgers WA, Passmore JA. Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women. J Immunol Methods 2010; 354:68-79.
24. Bere A, Denny L, Burgers WA, Passmore JA. Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract. Immunology 2010; 130:23-3.
25. Iqbal SM, Ball TB, Kimani J, Kiama P, Thottingal P, Embree JE, Fowke KR, Plummer FA. Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers. J Infect Dis 2005; 192:728-3.
26. Passmore JA, Milner M, Denny L et al. Comparison of cervical and blood T-cell responses to human papillomavirus-16 in women with human papillomavirus-associated cervical intraepithelial neoplasia. Immunology 2006; 119:507-14.
27. Trickett AE, Kwan YL, Cameron B, Dwyer JM. Ex vivo expansion of functional T lymphocytes from HIV-infected individuals. J Immunol Methods 2002; 262:71-83.
28. Roederer M, Nozzi JL, Nason MC. SPICE: exploration and analysis of post-cytometric complex multivariate data sets. Cytometry 2011; 79A:167-74.
29. Columb MO, Sagadai S. Multiple comparisons. Curr Anaesth Crit Car 2006; 17:233-6.
30. Addo MM, Yu XG, Rathod A et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol 2003; 77:2081-92.
31. + T cell responses by intracellular cytokine production. Immunol Lett 2001; 79:117-25.
32. + T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol 2002; 76:2298-305.
33. Kaufmann DE, Bailey PM, Sidney J et al. Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J Virol 2004; 78:4463-77.
34. + cell responses. J Infect Dis 2005; 192:1588-96.
35. Brenchley JM, Price DA, Douek DC. HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006; 7:235-9.
36. + T-cell effector activity in HIV primary infection. J Clin Invest 1999; 104:1431-9.
37. Ogg GS, Dong T, Hansasuta P et al. Four novel cytotoxic T-lymphocyte epitopes in the highly conserved major homology region of HIV-1 gag, restricted through B*4402, B*1801, A*2601, B*70 (B*1509). AIDS 1998; 12:1561-3.