A prospective study of serotonin transporter gene promoter (5-HTT gene linked polymorphic region) and intron 2 (variable number of tandem repeats) polymorphisms as predictors of trauma response to mild physical injury

DNA and Cell Biology

Volumn 29, Issue 2, 2010, Pages 71-77

  Sayin, Aslihan ^a   Kucukyildirim, Sibel ^b   Akar, Taner ^a   Bakkaloglu, Zekiye ^b   Demircan, Ahmet ^a   Kurtoglu, Gulhan ^a   Demirel, Birol ^a   Candansayar, Selcuk ^a   Mergen, Hatice ^b  

^a GAZI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; AROUSAL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; INJURY; INJURY SEVERITY; INTRON; MAJOR CLINICAL STUDY; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; SEROTONIN TRANSPORTER GENE; SYMPTOM; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 84879192659     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0936     Document Type: Article

References (35)

1. Aker, A.T., Özeren, M., Başoǧlu, M., Kaptanoǧlu, C., Erol, A., and Buran, B. (1999). Clinician administered post-traumatic stress disorder scale (CAPS) reliability and validity study. Turk J Psychiatry 10, 286-293.
2. Blake, D.D., Weathers, F.W., Nagy, L.M., Kaloupek, D.G., Gusman, F.D., Charney, D.S., and Keane, T. (1995). The development of clinician administered PTSD scale. J Trauma Stress 8, 75-90.
3. Blanchard, E.B., Hickling, E.J., Taylor, A.E., Loos, W., Forneris, C.A., and Jaccard, J. (1996). Who develops PTSD from motor vehicle accidents? Behav Res Ther 34, 1-10.
4. Bremner, J.D. (2006). The relationship between cognitive and brain changes in posttraumatic stress disorder. Ann NY Acad Sci 1071, 80-86.
5. Breslau, N., Kessler, R., Chilcoat, H.D., Schultz, L.R., Davis, G.C., and Andreski, P. (1998). Trauma and posttraumatic stress disorder in the community: the 1996 Detroit area survey of trauma. Arch Gen Psychiatry 55, 626-632.
6. Broekman, B.F., Olff, M., and Boer, F. (2007). The genetic background of PTSD. Neurosci Biobehav Rev 31, 348-362.
7. Comings, D.E., Comings, B.G., Muhleman, D., Dietz, G., Shabbahrami, B., and Tast, D. (1991). The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorder. JAMA 266, 1793-1800.
8. Comings, D.E., Muhleman, D., and Gysin, R. (1996). Dopamine receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication. Biol Psychiatry 40, 368-372.
9. Davis, L.L., Clark, D.M., Kramer, G.L., Moeller, F.G., and Petty, F. (1999). D-fenfluramine challenge in posttraumatic stress disorder. Biol Psychiatry 45, 928-930.
10. Gelernter, J., Southwick, S., Goodson, S., Morgan, A., Nagy, L., and Charney, D.S. (1999). No association between D2 dopamine receptor (DRD2) ''A'' system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biol Psychiatry 45, 620-625.
11. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., and Lesch, K.P. (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66, 1-4.
12. Ipser, J., Seedat, S., and Stein, D.J. (2006). Pharmacotherapy for post-traumatic stress disorder: a systemic review and metaanalysis. S Afr Med J 96, 1088-1096. (Pubitemid 44649837)
13. Kaehler, S., Singewald, N., Singer, C., Thurnher, C., and Philippu, A. (2000). Conditioned fear and inescapable shock modify the release of serotonin in the locus coeruleus. Brain Res 859, 249-254.
14. Kessler, R.C., Sonnega, A., Bromet, E., Hughes, M., and Nelson, C.B. (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 52, 1048-1060.
15. Kilpatrick, D.G., Koenen, K.C., Ruggiero, K.J., Acierno, R., Galea, S., Resnick, H.S., Roitzsch, J., Boyle, J., and Gelernter, J. (2007). The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. Am J Psychiatry 164, 1693-1699.
16. Lanius, R.A., Bluhm, R., Lanius, U., and Pain, C. (2006). A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation. J Psychiatr Res 40, 709-729.
17. Lee, H.J., Lee, M.S., Kang, R.H., Kim, H., Kim, S.D., Kee, B.S., Kim, Y.H., Kim, Y.K., Kim, J.B., Yeon, B.K., Oh, K.S., Oh, B.H., Yoon, J.S., Lee, C., Jung, H.Y., Chee, I.S., and Paik, H. (2005). Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety 21, 135-139.
18. Lesch, K.P., Balling, U., Gross, J., Strauss, K., Wolozin, B.L., Murphy, D.L., and Riederer, P. (1994). Organization of human serotonin transporter gene. J Neural Transm 95, 157-162.
19. Li, T., Holmes, C., Sham, P.C., Vallada, H.P., Birkett, J., Kirov, G., Lesch, K.P., Powell, J., Lovestone, S., and Collier, D. (1997). Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease. Neuroreport 8, 683-686.
20. Lin, P.Y., and Tsai, G. (2004). Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 55, 1023-1030.
21. MacKenzie, A., and Quinn, J. (1999). A serotonin transporter gene intron 2 polymorphic region correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 96, 15251-15255.
22. Maes, M., Lin, A.H., Verkerk, R., Delmeire, L., Van Gastel, A., Van der Planken, M., and Scharpe, S. (1999). Serotonergic and noradrenergic markers of post-traumatic stress disorder with and without major depression. Neuropsychopharmacology 20, 188-197.
23. Matsumoto, M., Higuchi, K., Togashi, H., Koseki, H., Yamaguchi, T., Kanno, M., and Yoshioka, M. (2005). Early postnatal stress alters the 5-Htergic modulation to emotional stress at postadolescent periods of rats. Hippocampus 15, 775-781.
24. Michaels, A.J., Michaels, C.E., Moon, C.H., Smith, J.S., Zimmerman, M.A., Thaeri, P.A., and Peterson, C. (1999). Posttraumatic stress disorder after injury: impact on general health outcome and early risk assessment. J Trauma 47, 460-467.
25. Nugent, N.R., Amstadter, A.B., and Koenen, K.C. (2008). Genetics of post-traumatic stress disorder: informing clinical conceptualizations and promoting future research. Am J Med Gen 148C, 127-132.
26. Ohara, K., Nagai, M., Tsukamoto, I., Tani, K., and Suzuki, Y. (1998). Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorder. Biol Psychiatry 44, 550-554.
27. Opler, L.A., Grennan, M.S., and Opler, M.G. (2006). Pharmacotherapy of post-traumatic stress disorder. Drugs Today (Barc) 42, 803-809.
28. Segman, R.H., Cooper-Kazaz, R., Macciardi, F., Goltser, T., Halfon, Y., Dobroborski, T., and Shalev, A.Y. (2002). Association between the dopamine transporter gene and posttraumatic stress disorder. Mol Psychiatry 7, 903-907.
29. Shin, L., Rauch, S., and Pitman, R. (2006). Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann NY Acad Sci 1071, 67-79.
30. Spivak, B., Vered, Y., Graff, E., Blum, I., Mester, R., and Weizman, A. (1999). Low platelet-poor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder. Biol Psychiatry 45, 840-845.
31. Steiger, H., Richardson, J., Joober, R., Gauvin, L., Israel, M., Bruce, K.R., Ying Kin, N.M., Howard, H., and Young, S.N. (2007). The 5HTTLPR polymorphism, prior maltreatment and dramaticerratic personality manifestations in women with bulimic syndromes. J Psychiatr Neurosci 32(5), 354-362
32. Ursano, R.J., Fullerton, C.S., Epstein, R.S., Crowley, B., Kao, T.C., Vance, K., Craig, K.J., Dougall, A.L., and Baum, A. (1999). Acute and chronic posttraumatic stress disorder in motor vehicle accident victims. Am J Psychiatry 156, 589-595. (Pubitemid 29162981)
33. Weiss, S.J. (2007). Neurobiological alterations associated with traumatic stress. Perspect Psyhiatr Care 43, 114-122.
34. Young, R.M., Lawford, B.R., Noble, E.P., Kanin, B., Wilkie, A., Ritchie, T., Arnold, L., and Shadforth, S. (2002). Harmful drinking in military veterans with posttraumatic stress disorder: association with the D2 dopamine receptor A1 allele. Alcohol Alcohol 37, 451-456.
35. Zatzick, D.F., Kang, S.M., Müller, H.G., Russo, J.E., Rivara, F.P., Katon, W., Jurkovich, G.J., and Roy-Byrne, P. (2002). Predicting posttraumatic stress in hospitalized trauma survivors with acute injuries. Am J Psychiatry 159, 941-946.