Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats

Archives of Toxicology

Volumn 87, Issue 7, 2013, Pages 1265-1272

  Weiss, Tobias ^a   Bolt, Hermann M ^b   Schlüter, Gerhard ^a   Koslitz, Stephan ^a   Taeger, Dirk ^a   Welge, Peter ^a   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

2 Naphthylamine; Bladder cancer; Haemoglobin adducts; Metabolism; N phenyl 2 naphthylamine; Urine

Indexed keywords

2 NAPHTHYLAMINE; ANTIOXIDANT; HEMOGLOBIN; N PHENYL 2 NAPHTHYLAMINE; RUBBER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CHEMICAL BINDING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPHENYLATION; FEMALE; HYDROXYLATION; MALE; METABOLISM; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE ANALYSIS; RAT; URINARY EXCRETION; URINE LEVEL;

2-NAPHTHYLAMINE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HYDROXYLATION; MALE; RATS; RISK ASSESSMENT; TANDEM MASS SPECTROMETRY; URINARY BLADDER NEOPLASMS;

ANIMALIA; MAMMALIA; RATTUS;

EID: 84879182387     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1025-5     Document Type: Article

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