Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite

Current Drug Discovery Technologies

Volumn 3, Issue 2, 2006, Pages 101-114

  Wang, Jianyao ^a   DeMaio, William ^a   Chandrasekaran, Appavu ^a   Shen, Li ^a   Bach II, Alvin C ^a   Scatina, JoAnn ^a   Talaat, Rasmy ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYPHENYL 2 NAPHTHYLAMINE; AMINE; BUFFER; CYTOCHROME P450; DIOXANE DERIVATIVE; DRUG METABOLITE; IMINE; N PARA HYDROXY BENZODIOXANE DERIVATIVE; N PARA HYDROXY METABOLITE; OXYGEN; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; EPOXIDATION; HYDROLYSIS; INCUBATION TIME; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL;

2-NAPHTHYLAMINE; ANIMALS; BENZOQUINONES; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DIOXANES; DIPEPTIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; INDICATORS AND REAGENTS; LYSINE; MASS SPECTROMETRY; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXYGEN ISOTOPES; PHENYLALANINE;

EID: 33747867835     PISSN: 15701638     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016306778108901     Document Type: Article

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