Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 6, 2013, Pages 4271-4277

  Cull, Grant ^a   Burgoyne, Claude F ^a   Fortune, Brad ^a   Wang, Lin ^a  

^a DEVERS EYE INSTITUTE   (United States)

Author keywords

Blood flow; Experimental glaucoma; Intraocular pressure; Optic nerve head

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B SCAN; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GLAUCOMA; HEMODYNAMICS; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; MALE; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RETINAL NERVE FIBER LAYER THICKNESS; RHESUS MONKEY; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TONOMETRY; TRABECULAR MESHWORK;

BLOOD FLOW; EXPERIMENTAL GLAUCOMA; INTRAOCULAR PRESSURE; OPTIC NERVE HEAD;

ANIMALS; BLOOD FLOW VELOCITY; DISEASE MODELS, ANIMAL; FEMALE; GLAUCOMA; INTRAOCULAR PRESSURE; LASER-DOPPLER FLOWMETRY; LONGITUDINAL STUDIES; MACACA MULATTA; MALE; NERVE FIBERS; OPTIC DISK; OPTIC NERVE DISEASES; REGIONAL BLOOD FLOW; RETINAL GANGLION CELLS; TOMOGRAPHY, OPTICAL COHERENCE; TONOMETRY, OCULAR;

EID: 84879173281     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12013     Document Type: Article

References (47)

1. Jia YL, Morrison JC, Tokayer J, et al. Quantitative OCT angiography of optic nerve head blood flow. Biomedical Optics Express. 2012;3:3127-3137.
2. Yokoyama Y, Aizawa N, Chiba N, et al. Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk. Clin Ophthalmol. 2011;5:1721-1727.
3. Sugiyama T, Shibata M, Kojima S, Ikeda T. Optic nerve head blood flow in glaucoma. In: Kubena T, ed. Mystery of Glaucoma. New York: InTech; 2011:207-218.
4. Chiba N, Omodaka K, Yokoyama Y, et al. Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type. Clin Ophthalmol. 2011;5:1549-1556.
5. Sato EA, Ohtake Y, Shinoda K, Mashima Y, Kimura I. Decreased blood flow at neuroretinal rim of optic nerve head corresponds with visual field deficit in eyes with normal tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 2005;244:1-7.
6. Hafez AS, Bizzarro RL, Lesk MR. Evaluation of optic nerve head and peripapillary retinal blood flow in glaucoma patients, ocular hypertensives, and normal subjects. Am J Ophthalmol. 2003;136:1022-1031.
7. Piltz-Seymour JR, Grunwald JE, Hariprasad SM, Dupont J. Optic nerve blood flow is diminished in eyes of primary openangle glaucoma suspects. Am J Ophthalmol. 2001;132:63-69.
8. Findl O, Rainer G, Dallinger S, et al. Assessment of optic disk blood flow in patients with open-angle glaucoma. Am J Ophthalmol. 2000;130:589-596.
9. Kerr J, Nelson P, O'Brien C. A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol. 1998;126:42-51.
10. Michelson G, Schmauss B, Langhans MJ, Harazny J, Groh MJ. Principle, validity, and reliability of scanning laser Doppler flowmetry. J Glaucoma. 1996;5:99-105.
11. Michelson G, Langhans MJ, Groh MJ. Perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open angle glaucoma. J Glaucoma. 1996;5:91-98.
12. Hamard P, Hamard H, Dufaux J, Quesnot S. Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma. Br J Ophthalmol. 1994;78:449-453.
13. Maumenee AE. Causes of optic nerve damage in glaucoma. Robert N. Shaffer lecture. Ophthalmology. 1983;90:741-752.
14. Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359-393.
15. Hayreh SS. The 1994 Von Sallman Lecture. The optic nerve head circulation in health and disease. Exp Eye Res. 1995;61: 259-272.
16. Anderson DR. Introductory comments on blood flow autoregulation in the optic nerve head and vascular risk factors in glaucoma. Surv Ophthalmol. 1999;43;S5-S9.
17. Zink JM, Grunwald JE, Piltz-Seymour J, Staii A, Dupont J. Association between lower optic nerve laser Doppler blood volume measurements and glaucomatous visual field progression. Br J Ophthalmol. 2003;87:1487-1491.
18. Yaoeda K, Shirakashi M, Fukushima A, et al. Relationship between optic nerve head microcirculation and visual field loss in glaucoma. Acta Ophthalmol Scand. 2003;81:253-259.
19. Ciancaglini M, Carpineto P, Costagliola C, Matropasqua L. Perfusion of the optic nerve head and visual field damage in glaucomatous patients. Graefes Arch Clin Exp Ophthalmol. 2001;239:549-555.
20. Hwang JC, Konduru R, Zhang X, et al. Relationship among visual field, blood flow, and neural structure measurements in glaucoma. Invest Ophthalmol Vis Sci. 2012;53:3020-3026.
21. Resch H, Schmidl D, Hommer A, et al. Correlation of optic disc morphology and ocular perfusion parameters in patients with primary open angle glaucoma. Acta Ophthalmol. 2011;89: 544-549.
22. Januleviciene I, Ehrlich R, Siesky B, Nedzelskiene I, Harris A. Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations. Eur J Ophthalmol. 2009;19:790-797.
23. Schwartz B. Circulatory defects of the optic disk and retina in ocular hypertension and high pressure open-angle glaucoma. Surv Ophthalmol. 1994;38:S23-S34.
24. Shoshani Y, Harris A, Shoja MM, et al. Impaired ocular blood flow regulation in patients with open-angle glaucoma and diabetes. Clin Exp Ophthalmol. 2012;40:697-705.
25. Hollo G, van den Berg TJ, Greve EL. Scanning laser Doppler flowmetry in glaucoma. Int Ophthalmol. 1996;20:63-70.
26. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res. 2005;24:39-73.
27. Fortune B, Burgoyne CF, Cull GA, Reynaud J, Wang L. Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma. Invest Ophthalmol Vis Sci. 2012;53:3939-3950.
28. Alm A, Lambrou GN, Maepea O, Nilsson SF, Percicot C. Ocular blood flow in experimental glaucoma: a study in cynomolgus monkeys. Ophthalmologica. 1997;211:178-182.
29. Quigley HA, Hohman RM, Sanchez R, Addicks EM. Optic nerve head blood flow in chronic experimental glaucoma. Arch Ophthalmol. 1985;103:956-962.
30. Caprioli J, Miller JM. Measurement of optic nerve blood flow with iodoantipyrine: limitations caused by diffusion from the choroid. Exp Eye Res. 1988;47:641-652.
31. Wang L, Cull GA, Piper C, Burgoyne CF, Fortune B. Anterior and posterior optic nerve head blood flow in nonhuman primate experimental glaucoma model measured by laser speckle imaging technique and microsphere method. Invest Ophthalmol Vis Sci. 2012;53:8303-8309.
32. Fujii H, Nohira K, Yamamoto Y, Ikawa H, Hjura T. Evaluation of blood flow by laser speckle image sensing, Part 1. Appl Opt. 1987;26:5321-5325.
33. Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S. Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 2010;88:723-729.
34. Takahashi H, Sugiyama T, Tokushige H, et al. Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits. Exp Eye Res. 2013;108:10-15.
35. Piper C, Fortune B, Cull G, Cioffi GA, Wang L. Basal blood flow and autoregulation changes in the optic nerve of rhesus monkeys with idiopathic bilateral optic atrophy. Invest Ophthalmol Vis Sci. 2013;54:714-721.
36. Jia L, Cepurna WO, Johnson EC, Morrison JC. Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest Ophthalmol Vis Sci. 2000;41:3415-3419.
37. Kim J, Sapp HL Jr, Plummer CE, Brooks DE, Kim D, Kim MS. IOP change undergoing anesthesia in rhesus macaques (Macaca mulatta) with laser-induced ocular hypertension. J Vet Med Sci. 2012;74:1359-1361.
38. Gardiner SK, Fortune B, Wang L, Downs JC, Burgoyne CF. Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma. Exp Eye Res. 2012;103C:1-8.
39. Cull GA, Reynaud J, Wang L, Cioffi GA, Burgoyne CF, Fortune B. Relationship between orbital optic nerve axon counts and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53:7766-7773.
40. Riva CE, Harino S, Petrig BL, Shonat RD. Laser Doppler flowmetry in the optic nerve. Exp Eye Res. 1992;55:499-506.
41. Liang Y, Downs JC, Fortune B, Cull GA, Cioffi GA, Wang L. Impact of systemic blood pressure on the relationship between intraocular pressure and blood flow in the optic nerve head of non-human primates. Invest Ophthalmol Vis Sci. 2009;50:2164-2160.
42. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468:232-243.
43. Yang H, Downs JC, Girkin C, et al. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness. Invest Ophthalmol Vis Sci. 2007;48:4597-4607.
44. Yang H, Thompson H, Roberts MD, Sigal IA, Downs JC, Burgoyne CF. Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions. Invest Ophthalmol Vis Sci. 2011;52:345-363.
45. Roberts MD, Grau V, Grimm J, et al. Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2009;50:681-690.
46. Chauhan BC, LeVatte TL, Jollimore CA, et al. Model of endothelin-1-induced chronic optic neuropathy in rat. Invest Ophthalmol Vis Sci. 2004;45:144-152.
47. Cioffi GA. Ischemic model of optic nerve injury. Trans Am Ophthalmol Soc. 2005;103:592-613.