Minor Changes in Gene Expression in the Mouse Preoptic Hypothalamic Region by Inflammation-Induced Prostaglandin E2

Journal of Neuroendocrinology

Volumn 25, Issue 7, 2013, Pages 635-643

  Vasilache, A M ^a   Kugelberg, U ^a   Blomqvist, A ^a   Nilsberth, C ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Fever; Heat shock proteins; Laser capture microdissection; Microsomal prostaglandin E synthase 1; Preoptic region; Prostaglandin E2; Whole genome microarray

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CYCLOOXYGENASE 2; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN A1A; HEAT SHOCK PROTEIN A1B; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E1; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; GENE DELETION; GENE EXPRESSION; GENOTYPE; HYPERTHERMIA; HYPOTHALAMUS; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MOTOR ACTIVITY; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; ANIMAL; DNA MICROARRAY; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; DINOPROSTONE; DNA PRIMERS; GENE EXPRESSION; HYPOTHALAMUS; INFLAMMATION; MALE; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84879171484     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12044     Document Type: Article

References (40)

1. Dantzer R, Bluthe RM, Gheusi G, Cremona S, Laye S, Parnet P, Kelley KW. Molecular basis of sickness behavior. Ann NY Acad Sci 1998; 856: 132-138.
2. Reyes TM, Walker JR, DeCino C, Hogenesch JB, Sawchenko PE. Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. J Neurosci 2003; 23: 5607-5616.
3. Mastronardi C, Whelan F, Yildiz OA, Hannestad J, Elashoff D, McCann SM, Licinio J, Wong M-L. Caspase 1 deficiency reduces inflammation-induced brain transcription. Proc Natl Acad Sci USA 2007; 104: 7205-7210.
4. Aid S, Langenbach R, Bosetti F. Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation 2008; 5: 17.
5. Nilsberth C, Hamzic N, Norell M, Blomqvist A. Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1. J Neuroendocrinol 2009; 21: 715-721.
6. Hamzic N, Blomqvist A, Nilsberth C. Immune-induced expression of lipocalin-2 in brain endothelial cells: relationship with interleukin-6, cyclooxygenase-2 and the febrile response. J Neuroendocrinol 2013; 25: 271-280.
7. Ek M, Engblom D, Saha S, Blomqvist A, Jakobsson PJ, Ericsson-Dahlstrand A. Inflammatory response: pathway across the blood-brain barrier. Nature 2001; 410: 430-431.
8. Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin- induced fever. J Neurosci 2001; 21: 2669-2677.
9. Engstrom L, Rosen K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D, Blomqvist A. Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology 2008; 149: 1436-1450.
10. Engblom D, Saha S, Engstrom L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci 2003; 6: 1137-1138.
11. Pecchi E, Dallaporta M, Thirion S, Salvat C, Berenbaum F, Jean A, Troadec JD. Involvement of central microsomal prostaglandin E synthase-1 in IL-1beta-induced anorexia. Physiol Genomics 2006; 25: 485-492.
12. Elander L, Engstrom L, Hallbeck M, Blomqvist A. IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1. Am J Physiol Regul Integr Comp Physiol 2007; 292: R258-R267.
13. 2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge. J Neurosci 2009; 29: 1404-1413.
14. Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest 2009; 119: 287-294.
15. Elander L, Ruud J, Korotkova M, Jakobsson PJ, Blomqvist A. Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide. Neurosci Lett 2010; 470: 10-12.
16. Engblom D, Ek M, Saha S, Ericsson-Dahlstrand A, Jakobsson PJ, Blomqvist A. Prostaglandins as inflammatory messengers across the blood-brain barrier. J Mol Med 2002; 80: 5-15.
17. Rudaya AY, Steiner AA, Robbins JR, Dragic AS, Romanovsky AA. Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature. Am J Physiol Regul Integr Comp Physiol 2005; 289: R1244-R1252.
18. 2 production specifically in brain endothelial cells. Endocrinology 2012; 153: 4849-4861.
19. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 1999; 96: 7220-7225.
20. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA 2003; 100: 9044-9049.
21. Vasilache AM, Andersson J, Nilsberth C. Expression of PGE(2) EP(3) receptor subtypes in the mouse preoptic region. Neurosci Lett 2007; 423: 179-183.
22. 3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 2007; 10: 1131-1133.
23. 3 receptors. J Physiol 2003; 551: 945-954.
24. 2. Endocrinology 2009; 150: 1850-1860.
25. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4: 249-264.
26. Wu ZJ, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F. A model-based background adjustment for oligonucleotide expression arrays. JASA 2004; 99: 909-917.
27. Affymetrix. Guide to Probe Logarithmic Intensity Error (PLIER) Estimation. http://media.affymetrix.com/support/technical/technotes/plier_technote.pdf
28. Tung Y-CL, Ma M, Piper S, Coll A, O'Rahilly S, Yeo GSH. Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus. J Neurosci 2008; 28: 12419-12426.
29. Inoue W, Matsumura K, Yamagata K, Takemiya T, Shiraki T, Kobayashi S. Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever. Neurosci Res 2002; 44: 51-61.
30. Konsman JP, Vigues S, Mackerlova L, Bristow A, Blomqvist A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J Comp Neurol 2004; 472: 113-129.
31. 2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur J Neurosci 1999; 11: 2651-2668.
32. 3 prostaglandin E(2) receptor subtype in the rat brain: relationship to sites of interleukin-1-induced cellular responsiveness. J Comp Neurol 2000; 428: 5-20.
33. Saha S, Engstrom L, Mackerlova L, Jakobsson PJ, Blomqvist A. Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1100-R1107.
34. Fritz M, Klawonn AM, Wilhelms D, Örtegren U, Ridder DA, Hamzic N, Nilsberth C, Schwaninger M, Blomqvist A, Engblom D. The affective component of systemic inflammation - a new role for prostaglandins. Soc Neurosci Abstr 2012; 587.12/UU16.
35. Elmquist JK, Scammell TE, Jacobson CD, Saper CB. Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J Comp Neurol 1996; 371: 85-103.
36. Dallaporta M, Pecchi E, Jacques C, Berenbaum F, Jean A, Thirion S, Troadec JD. c-Fos immunoreactivity induced by intraperitoneal LPS administration is reduced in the brain of mice lacking the microsomal prostaglandin E synthase-1 (mPGES-1). Brain Behav Immun 2007; 21: 1109-1121.
37. Zhang YH, Lu J, Elmquist JK, Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol 2003; 463: 3-12.
38. Cosgrove JW, Brown IR. Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide. Proc Natl Acad Sci USA 1983; 80: 569-573.
39. 3 receptors. J Biol Chem 2008; 283: 11064-11071.
40. Saper CB, Romanovsky AA, Scammell TE. Neural circuitry engaged by prostaglandins during the sickness syndrome. Nat Neurosci 2012; 15: 1088-1095.