Effects of Sijunzi decoction and Yupingfeng powder on expression of janus kinase-signal transducer and activator of transcription signal pathway in the brain of spleen-deficiency model rats

Journal of Traditional Chinese Medicine

Volumn 33, Issue 1, 2013, Pages 78-84

  Xiong, Bin ^a,b   Qian, Huinan ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b HUBEI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

JAK STAT signal pathway; Sijunzi decoction; Spleen deficiency; Yupingfeng powder

Indexed keywords

BLOOD CLOTTING FACTOR 11; CHINESE DRUG; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 4; PROLACTIN; PROLACTIN RECEPTOR; SIJUNZI DECOCTION; SMAD3 PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG; YUPINGFENG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; MALE; MOLECULAR DYNAMICS; NONHUMAN; PERFUSION; POWDER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPLEEN DISEASE;

EID: 84879162938     PISSN: 02552922     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0254-6272(13)60105-3     Document Type: Article

References (19)

1. Aaronson D S, Horvath C M. A road map for those who know JAK-STAT. Science 2002; 296(5573): 1653-1655.
2. Greenhalgh C J, Hilton D J. Negative regulation of cytokine signaling. J Leukoc Biol 2001; 70(3): 348-356.
3. Heinrich P C, Behrmann I, Haan S, Hermanns H M, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374(Pt 1): 1-20.
4. O'Shea J J, Gadina M, Schreiber R D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109(Suppl): S121-S131.
5. Rogers R S, Horvath C M, Matunis M J. SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. J Biol Chem 2003; 278(32): 30091-30097.
6. Dziadziuszko R, Witta S E, Cappuzzo F, et al. Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res 2006; 12(10): 3078-3084.
7. Li M. Correlativity of IL-10 gene polymorphism with diseases of the digestive system. Yi Xue Zong Shu 2006; 12(18): 1097-1099.
8. Matera L, Galetto A, Geuna M, et al. Individual andcombined effect of granulocyte-macrophage colony-stimulation factor and prolaction on maturation of dendritic cells from blood monocytes under serum-free conditions. Immunology 2000; 100(1): 29.
9. Reeves R, Beckerbauer L. HMGI(Y) proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta 2001; 1519(1-2): 13-19.
10. Letterio J J. TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia. Oncogene 2005; 24(37): 5701-5712.
11. Yang X, Letterio J, Lechleider R J, et al. Targeted disruptine of SMAD3 results in impaired mucosal and diminished T cell responsiveness to TGF-beta. EMBO J 1999; 18(5): 1280-1291.
12. Chen W F. Medical Immunology. Beijing: The People's Medical Publishing House, 2001: 94-96.
13. Kouros-Mehr H, Slorach E M, Sternlicht M D, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in themammary gland. Cell 2006; 127(5): 1041-1055.
14. To Y, Dohi M, Tanaka R, Sato A, Nakagome K, Yamamoto K. Early in interleukin-4 dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma. Lab Invest 2001; 21(12): 1385-1396.
15. Kelly-Welch A E, Hanson E M, Boothby M R, Keegan A D. Interleukin-4 and interleukin-13 signaling connections maps. Science 2003; 300(5625): 1527-1528.
16. Qian H N, Gong S M. Changes of IL-10 level and gene expression in brain of the rat with deficiency syndrome and intervening action of the drug for supplementing Qi and strengthening genuine Qi. Zhong Hua Zhong Yi Yao Xue Kan 2009; 27(6): 1150-1152.
17. Yang S, Qian H N. Effects of the drug for strengthening genuine Qi and supplementing Qi on IL-6Rα level and gene expression in brain of the rat with deficiency syndrome. Anhui Zhong Yi Yao Xue Yuan Xue Bao 2010; 29(4): 45-51.
18. Qian H N, Yang S. Expression of cytokine IFN-γ activity in brain of the rat with deficiency syndrome and intervening mechanism of the drug for strengthening genuine Qi and supplementing Qi. Beijing Zhong Yi Yao Da Xue Xue Bao 2011; 34(3): 174-188.
19. Qian H N, Gong S M, Yang S, et al. Study on changes of IL-18 protein and gene expression in brain of the rat with deficiency syndrome and intervening of the drug for strengthening genuine Qi and supplementing Qi. Beijing Zhong Yi Yao Da Xue Xue Bao 2010; 33(7): 472-475.