Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

Journal of Molecular Cell Biology

Volumn 5, Issue 4, 2013, Pages 227-238

  Cai, Jin ^a   Han, Yu ^a   Ren, Hongmei ^a   Chen, Caiyu ^a   He, Duofen ^a   Zhou, Lin ^a   Eisner, Gilbert M ^b   Asico, Laureano D ^c   Jose, Pedro A ^c   Zeng, Chunyu ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

AT1 receptor; BCR ABL hybrid gene; extracellular vesicles; genomic DNA

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; BCR ABL PROTEIN; GENOMIC DNA;

ADULT; AGED; ARTICLE; CELL FUNCTION; CELL NUCLEUS; CELL VACUOLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; MALE; MOLECULAR MECHANICS; NEUTROPHIL; SIGNAL TRANSDUCTION;

EID: 84879154392     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjt011     Document Type: Article

References (35)

1. Al-Nedawi, K., Meehan, B., Micallef, J., et al. (2008). Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10, 619-624. (Pubitemid 351627382)
2. Ashiru, O., Boutet, P., Fernandez-Messina, L., et al. (2010). Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA 008 that is shed by tumor cells in exosomes. Cancer Res. 70, 481-489.
3. Balaj, L., Lessard, R., Dai, L., et al. (2011). Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat. Commun. 2, 180.
4. Bruno, S., Grange, C., Deregibus, M.C., et al. (2009). Mesenchymal stem cellderived microvesicles protect against acute tubular injury. J. Am. Soc. Nephrol. 20, 1053-1067.
5. Cai, J., Yao, C., Xia, J., et al. (2011). Rapid parallelized and quantitative analysis of five pathogenic bacteria by ITS hybridization using QCM biosensor. Sens. Actuators B Chem. 155, 500-504.
6. Chen, X., Ba, Y., Ma, L., et al. (2008). Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997-1006.
7. Clayton, A., Turkes, A., Dewitt, S., et al. (2004). Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 18, 977-979. (Pubitemid 39561497)
8. Cocucci, E., Racchetti, G., and Meldolesi, J. (2009). Shedding microvesicles: artefacts no more. Trends Cell Biol. 19, 43-51.
9. Denzer, K., Kleijmeer, M.J., Heijnen, H.F., et al. (2000). Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci. 113(Pt 19), 3365-3374.
10. Dragan, A.I., Pavlovic, R., McGivney, J.B., et al. (2012). SYBR Green I: fluorescence properties and interaction with DNA. J. Fluoresc. 22, 1189-1199.
11. Gibbings, D.J., Ciaudo, C., Erhardt, M., et al. (2009). Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat. Cell Biol. 11, 1143-1149.
12. Guescini, M., Guidolin, D., Vallorani, L., et al. (2010). C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction. Exp. Cell Res. 316, 1977-1984.
13. Klingbeil, A.U., Jacobi, J., Langenfeld, M.R., et al. (2000). Enhanced antinatriuresis in response to angiotensin II in essential hypertension. Am. J. Hypertens. 13, 986-993.
14. Li, Z., Yu, C., Han, Y., et al. (2008). Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 294, H2761-H2768.
15. Morelli, A.E., Larregina, A.T., Shufesky,W.J., et al. (2004). Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104, 3257-3266. (Pubitemid 39507144)
16. Ogawa, R., Tanaka, C., Sato, M., et al. (2010). Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem. Biophys. Res. Commun. 398, 723-729.
17. Pap, E., Pallinger, E., Pasztoi, M., et al. (2009). Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm. Res. 58, 1-8.
18. Pelz, A.F., Kroning, H., Franke, A., et al. (2002). High reliability and sensitivity of the BCR/ABL1 D-FISH test for the detection of BCR/ABL rearrangements. Ann. Hematol. 81, 147-153. (Pubitemid 36067594)
19. Pluk, H., Dorey, K., and Superti-Furga, G. (2002). Autoinhibition of c-Abl. Cell 108, 247-259. (Pubitemid 34161144)
20. Puissant, A., Dufies, M., Fenouille, N., et al. (2012). Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness. J. Mol. Cell Biol. 4, 207-220.
21. Shibata, Y.,Malhotra, A., and Dutta, A. (2010). Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET. Genome Med. 2, 70.
22. Skog, J., Wurdinger, T., van Rijn, S., et al. (2008). Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476.
23. Thery, C., Ostrowski, M., and Segura, E. (2009). Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9, 581-593.
24. Trajkovic, K., Hsu, C., Chiantia, S., et al. (2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244-1247. (Pubitemid 351323020)
25. Valadi, H., Ekstrom, K., Bossios, A., et al. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654-659. (Pubitemid 47214727)
26. Wahlgren, J., Karlson, T.D., Brisslert, M., et al. (2012). Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes. Nucleic Acids Res. 40, e130.
27. Waldenstrom, A., Genneback, N., Hellman, U., et al. (2012). Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS One 7, e34653.
28. Wang, H., Wang, Z.H., Kong, J., et al. (2012). Oxidized low-density lipoproteindependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress. Mol. Med. 18, 159-166.
29. Xu, Z., Lin, S., Wu, W., et al. (2008). Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-kappaB pathways and mitochondrial protective mechanisms. Toxicology 247, 133-138.
30. Zen, K., and Zhang, C.Y. (2012). Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med. Res. Rev. 32, 326-348.
31. Zeng, C., Asico, L.D., Wang, X., et al. (2003). Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR. Hypertension 41, 724-729. (Pubitemid 36314582)
32. Zeng, C., Liu, Y., Wang, Z., et al. (2006). Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ. Res. 99, 494-500. (Pubitemid 44337821)
33. Zhang, C., Knudson, J.D., Setty, S., et al. (2005). Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors. Am. J. Physiol. Heart Circ. Physiol. 288, H2154-H2162. (Pubitemid 40604100)
34. Zhang, Y., Liu, D., Chen, X., et al. (2010). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol. Cell 39, 133-144.
35. Zwicker, J.I. (2010). Impedance-based flow cytometry for the measurement of microparticles. Semin. Thromb. Hemost. 36, 819-823.